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Murcko scaffold

2(1H)-Pyrimidinone scaffold

795 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
7
Chemicals
795
With full pages
104
Scaffold SMILES

O=c1nccc[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the 2(1H)-Pyrimidinone page
Murcko scaffold O=c1nccc[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 795 chemicals

Cytosine chemical structure, C4H5N3O, CAS 71-30-7
Cytosine
CAS 71-30-7C4H5N3O
Flucytosine chemical structure, C4H4FN3O, CAS 2022-85-7
Flucytosine
CAS 2022-85-7C4H4FN3O
2-Hydroxy-4,6-dimethylpyrimidine chemical structure, C6H8N2O, CAS 108-79-2
2-Hydroxy-4,6-dimethylpyrimidine
CAS 108-79-2C6H8N2O
6-Amino-5-iodo-2(1H)-pyrimidinone chemical structure, C4H4IN3O, CAS 1122-44-7
6-Amino-5-iodo-2(1H)-pyrimidinone
CAS 1122-44-7C4H4IN3O
Cidofovir chemical structure, C8H14N3O6P, CAS 113852-37-2
Cidofovir
CAS 113852-37-2C8H14N3O6P
5-Methylcytosine chemical structure, C5H7N3O, CAS 554-01-8
5-Methylcytosine
CAS 554-01-8C5H7N3O
6-Methoxy-5-methyl-2(1H)-pyrimidinone chemical structure, C6H8N2O2, CAS 25902-89-0
6-Methoxy-5-methyl-2(1H)-pyrimidinone
CAS 25902-89-0C6H8N2O2
2(1H)-Pyrimidinone chemical structure, C4H4N2O, CAS 557-01-7
2(1H)-Pyrimidinone
CAS 557-01-7C4H4N2O
5-(Hydroxymethyl)cytosine chemical structure, C5H7N3O2, CAS 1123-95-1
5-(Hydroxymethyl)cytosine
CAS 1123-95-1C5H7N3O2
Cytallene chemical structure, C8H9N3O2, CAS 114987-19-8
Cytallene
CAS 114987-19-8C8H9N3O2
5-Bromocytosine chemical structure, C4H4BrN3O, CAS 2240-25-7
5-Bromocytosine
CAS 2240-25-7C4H4BrN3O
5-Carboxycytosine chemical structure, C5H5N3O3, CAS 3650-93-9
5-Carboxycytosine
CAS 3650-93-9C5H5N3O3
1-Methylcytosine chemical structure, C5H7N3O, CAS 1122-47-0
1-Methylcytosine
CAS 1122-47-0C5H7N3O
4,6-Diamino-2-hydroxy-5-pyrimidinesulfonic acid chemical structure, C4H6N4O4S, CAS 74039-24-0
4,6-Diamino-2-hydroxy-5-pyrimidinesulfonic acid
CAS 74039-24-0C4H6N4O4S
4-Pyrimidinecarboxylic acid, 6-amino-2-hydroxy-5-methyl- chemical structure, C6H7N3O3, CAS 20865-52-5
4-Pyrimidinecarboxylic acid, 6-amino-2-hydroxy-5-methyl-
CAS 20865-52-5C6H7N3O3
Cytidine dialdehyde chemical structure, C9H11N3O5, CAS 61074-05-3
Cytidine dialdehyde
CAS 61074-05-3C9H11N3O5
N4-Acetylcytosine chemical structure, C6H7N3O2, CAS 14631-20-0
N4-Acetylcytosine
CAS 14631-20-0C6H7N3O2
5-Methyl-N(4)-hydroxycytosine chemical structure, C5H7N3O2, CAS 3171-25-3
5-Methyl-N(4)-hydroxycytosine
CAS 3171-25-3C5H7N3O2
5-Bromo-2(1H)-pyrimidinone chemical structure, C4H3BrN2O, CAS 38353-06-9
5-Bromo-2(1H)-pyrimidinone
CAS 38353-06-9C4H3BrN2O
5-Fluoropyrimidin-2-one chemical structure, C4H3FN2O, CAS 2022-78-8
5-Fluoropyrimidin-2-one
CAS 2022-78-8C4H3FN2O
4-Ethylthymine chemical structure, C7H10N2O2, CAS 10557-55-8
4-Ethylthymine
CAS 10557-55-8C7H10N2O2
5-Chloro-2(1H)-pyrimidinone chemical structure, C4H3ClN2O, CAS 54326-16-8
5-Chloro-2(1H)-pyrimidinone
CAS 54326-16-8C4H3ClN2O
1-(2-Hydroxyethyl)-4,6-dimethyl-2(1H)-pyrimidinone chemical structure, C8H12N2O2, CAS 14716-32-6
1-(2-Hydroxyethyl)-4,6-dimethyl-2(1H)-pyrimidinone
CAS 14716-32-6C8H12N2O2
6-(Methylamino)-2(1H)-pyrimidinone chemical structure, C5H7N3O, CAS 6220-47-9
6-(Methylamino)-2(1H)-pyrimidinone
CAS 6220-47-9C5H7N3O