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Murcko scaffold

Ring system with 2 rings and 15 atoms

43 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
43
With full pages
15
Scaffold SMILES

O=c1nccc(SCc2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1nccc(SCc2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 43 of 43 chemicals

6-[(2-Chlorobenzyl)sulfanyl]pyrimidin-2(1H)-one chemical structure, C11H9ClN2OS, CAS 6299-22-5
6-[(2-Chlorobenzyl)sulfanyl]pyrimidin-2(1H)-one
CAS 6299-22-5C11H9ClN2OS
4-((2,4-Dichlorobenzyl)thio)pyrimidin-2(1H)-one chemical structure, C11H8Cl2N2OS, CAS 6299-23-6
4-((2,4-Dichlorobenzyl)thio)pyrimidin-2(1H)-one
CAS 6299-23-6C11H8Cl2N2OS
6-Methyl-4-((3-methylbenzyl)thio)pyrimidin-2(1H)-one chemical structure, C13H14N2OS, CAS 898441-16-2
6-Methyl-4-((3-methylbenzyl)thio)pyrimidin-2(1H)-one
CAS 898441-16-2C13H14N2OS
4-((3-Fluorobenzyl)thio)-6-methylpyrimidin-2(1H)-one chemical structure, C12H11FN2OS, CAS 898445-40-4
4-((3-Fluorobenzyl)thio)-6-methylpyrimidin-2(1H)-one
CAS 898445-40-4C12H11FN2OS
6-Methyl-4-[(2-methylphenyl)methylsulfanyl]-1H-pyrimidin-2-one chemical structure, C13H14N2OS, CAS 898441-34-4
6-Methyl-4-[(2-methylphenyl)methylsulfanyl]-1H-pyrimidin-2-one
CAS 898441-34-4C13H14N2OS
4-((2,5-Dimethylbenzyl)thio)-6-methylpyrimidin-2(1H)-one chemical structure, C14H16N2OS, CAS 898445-66-4
4-((2,5-Dimethylbenzyl)thio)-6-methylpyrimidin-2(1H)-one
CAS 898445-66-4C14H16N2OS
6-Methyl-4-((3-nitrobenzyl)thio)pyrimidin-2(1H)-one chemical structure, C12H11N3O3S, CAS 898421-54-0
6-Methyl-4-((3-nitrobenzyl)thio)pyrimidin-2(1H)-one
CAS 898421-54-0C12H11N3O3S
4-(4-Chlorobenzylthio)-6-methylpyrimidin-2(1H)-one chemical structure, C12H11ClN2OS, CAS 195002-97-2
4-(4-Chlorobenzylthio)-6-methylpyrimidin-2(1H)-one
CAS 195002-97-2C12H11ClN2OS
4-[(4-Bromophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one chemical structure, C12H11BrN2OS, CAS 195003-03-3
4-[(4-Bromophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one
CAS 195003-03-3C12H11BrN2OS
4-[(3,4-Dichlorophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one chemical structure, C12H10Cl2N2OS, CAS 898421-58-4
4-[(3,4-Dichlorophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one
CAS 898421-58-4C12H10Cl2N2OS
4-[(2,4-Dichlorophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one chemical structure, C12H10Cl2N2OS, CAS 898441-49-1
4-[(2,4-Dichlorophenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-2-one
CAS 898441-49-1C12H10Cl2N2OS
Ethyl 4-benzylsulfanyl-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H16N2O3S, CAS 899749-23-6
Ethyl 4-benzylsulfanyl-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899749-23-6C15H16N2O3S
Ethyl 4-[(2-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H15FN2O3S, CAS 900002-01-9
Ethyl 4-[(2-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
CAS 900002-01-9C15H15FN2O3S
Ethyl 4-[(3-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H15FN2O3S, CAS 899749-24-7
Ethyl 4-[(3-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899749-24-7C15H15FN2O3S
Ethyl 4-[(4-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H15FN2O3S, CAS 899957-04-1
Ethyl 4-[(4-fluorophenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899957-04-1C15H15FN2O3S
Ethyl 6-methyl-4-[(2-methylphenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C16H18N2O3S, CAS 899749-52-1
Ethyl 6-methyl-4-[(2-methylphenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899749-52-1C16H18N2O3S
Ethyl 6-methyl-4-[(4-methylphenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C16H18N2O3S, CAS 899957-32-5
Ethyl 6-methyl-4-[(4-methylphenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899957-32-5C16H18N2O3S
Ethyl 6-methyl-4-[(3-nitrophenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H15N3O5S, CAS 899957-40-5
Ethyl 6-methyl-4-[(3-nitrophenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899957-40-5C15H15N3O5S
Ethyl 4-[(2,5-dimethylphenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C17H20N2O3S, CAS 900002-53-1
Ethyl 4-[(2,5-dimethylphenyl)methylsulfanyl]-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
CAS 900002-53-1C17H20N2O3S
Ethyl 6-methyl-2-oxo-4-[[3-(trifluoromethyl)phenyl]methylsulfanyl]-1H-pyrimidine-5-carboxylate chemical structure, C16H15F3N2O3S, CAS 899957-42-7
Ethyl 6-methyl-2-oxo-4-[[3-(trifluoromethyl)phenyl]methylsulfanyl]-1H-pyrimidine-5-carboxylate
CAS 899957-42-7C16H15F3N2O3S
Ethyl 4-((4-bromobenzyl)thio)-6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylate chemical structure, C15H15BrN2O3S, CAS 900002-56-4
Ethyl 4-((4-bromobenzyl)thio)-6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylate
CAS 900002-56-4C15H15BrN2O3S
Ethyl 6-methyl-2-oxo-4-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1H-pyrimidine-5-carboxylate chemical structure, C16H15F3N2O3S, CAS 899957-45-0
Ethyl 6-methyl-2-oxo-4-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-1H-pyrimidine-5-carboxylate
CAS 899957-45-0C16H15F3N2O3S
Ethyl 6-methyl-4-((3-methylbenzyl)thio)-2-oxo-1,2-dihydropyrimidine-5-carboxylate chemical structure, C16H18N2O3S, CAS 899957-02-9
Ethyl 6-methyl-4-((3-methylbenzyl)thio)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
CAS 899957-02-9C16H18N2O3S
Ethyl 6-methyl-4-[(4-nitrophenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate chemical structure, C15H15N3O5S, CAS 899957-63-2
Ethyl 6-methyl-4-[(4-nitrophenyl)methylsulfanyl]-2-oxo-1H-pyrimidine-5-carboxylate
CAS 899957-63-2C15H15N3O5S