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Murcko scaffold

Ring system with 2 rings and 11 atoms

43 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
43
With full pages
4
Scaffold SMILES

c1cc(-c2cncs2)ncn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cc(-c2cncs2)ncn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 43 of 43 chemicals

4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine chemical structure, C9H10N4S, CAS 364334-94-1
4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine
CAS 364334-94-1C9H10N4S
(E)-N'-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl)-N-hydroxyformimidamide chemical structure, C10H11N5OS
(E)-N'-(4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl)-N-hydroxyformimidamide
C10H11N5OS
4-(Dimethyl-1,3-thiazol-5-yl)-N-methylpyrimidin-2-amine chemical structure, C10H12N4S, CAS 674333-58-5
4-(Dimethyl-1,3-thiazol-5-yl)-N-methylpyrimidin-2-amine
CAS 674333-58-5C10H12N4S
N'-(4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-pyrimidinyl)-N-hydroxyimidoformamide chemical structure, C10H11N5OS, CAS 566149-74-4
N'-(4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-pyrimidinyl)-N-hydroxyimidoformamide
CAS 566149-74-4C10H11N5OS
N-[4-Methyl-5-(2-methyl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide chemical structure, C11H12N4OS, CAS 790702-20-4
N-[4-Methyl-5-(2-methyl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide
CAS 790702-20-4C11H12N4OS
5-(2,6-Dimethylpyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C10H12N4S, CAS 790706-79-5
5-(2,6-Dimethylpyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 790706-79-5C10H12N4S
5-(6-Chloro-2-methylpyrimidin-4-yl)thiazole chemical structure, C8H6ClN3S, CAS 1159818-34-4
5-(6-Chloro-2-methylpyrimidin-4-yl)thiazole
CAS 1159818-34-4C8H6ClN3S
4-Amino-2-methyl-6-(5-thiazolyl)pyrimidine chemical structure, C8H8N4S, CAS 1159820-67-3
4-Amino-2-methyl-6-(5-thiazolyl)pyrimidine
CAS 1159820-67-3C8H8N4S
4-Chloro-2-methyl-6-(2-methyl-5-thiazolyl)pyrimidine chemical structure, C9H8ClN3S, CAS 1159819-11-0
4-Chloro-2-methyl-6-(2-methyl-5-thiazolyl)pyrimidine
CAS 1159819-11-0C9H8ClN3S
4-Amino-2-methyl-6-(2-methyl-5-thiazolyl)pyrimidine chemical structure, C9H10N4S, CAS 1159819-18-7
4-Amino-2-methyl-6-(2-methyl-5-thiazolyl)pyrimidine
CAS 1159819-18-7C9H10N4S
5-(2-(Diethylamino)pyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C12H17N5S, CAS 1163707-01-4
5-(2-(Diethylamino)pyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 1163707-01-4C12H17N5S
2,5-Dichloro-4-(dimethyl-1,3-thiazol-5-yl)pyrimidine chemical structure, C9H7Cl2N3S, CAS 930580-28-2
2,5-Dichloro-4-(dimethyl-1,3-thiazol-5-yl)pyrimidine
CAS 930580-28-2C9H7Cl2N3S
4-Methyl-5-(2-methyl-pyrimidin-4-yl)-thiazol-2-ylamine chemical structure, C9H10N4S, CAS 1163706-73-7
4-Methyl-5-(2-methyl-pyrimidin-4-yl)-thiazol-2-ylamine
CAS 1163706-73-7C9H10N4S
4-Methyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-2-amine chemical structure, C9H10N4S2, CAS 790706-76-2
4-Methyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-2-amine
CAS 790706-76-2C9H10N4S2
5-[2-[1,1-Di(methyl-d3)ethyl-2,2,2-d3]-4-pyrimidinyl]-4-methyl-2-thiazolamine chemical structure, C12H16N4S, CAS 1163707-20-7
5-[2-[1,1-Di(methyl-d3)ethyl-2,2,2-d3]-4-pyrimidinyl]-4-methyl-2-thiazolamine
CAS 1163707-20-7C12H16N4S
4-(2,4-Dimethyl-thiazol-5-yl)-2-methanesulfonyl-pyrimidine chemical structure, C10H11N3O2S2, CAS 952400-03-2
4-(2,4-Dimethyl-thiazol-5-yl)-2-methanesulfonyl-pyrimidine
CAS 952400-03-2C10H11N3O2S2
4-(2,4-Dimethyl-thiazol-5-yl)-2-methylsulfanyl-pyrimidine chemical structure, C10H11N3S2, CAS 952400-02-1
4-(2,4-Dimethyl-thiazol-5-yl)-2-methylsulfanyl-pyrimidine
CAS 952400-02-1C10H11N3S2
5-(6-Chloropyrimidin-4-yl)-2,4-dimethylthiazole chemical structure, C9H8ClN3S, CAS 943313-98-2
5-(6-Chloropyrimidin-4-yl)-2,4-dimethylthiazole
CAS 943313-98-2C9H8ClN3S
5-(2-tert-Butyl-6-methylpyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C13H18N4S, CAS 1217487-74-5
5-(2-tert-Butyl-6-methylpyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 1217487-74-5C13H18N4S
4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyrimidin-4-yl)thiazol-2-amine chemical structure, C12H13F3N4S, CAS 1217487-47-2
4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyrimidin-4-yl)thiazol-2-amine
CAS 1217487-47-2C12H13F3N4S
5-(2-(1-Fluoro-2-methylpropan-2-yl)pyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C12H15FN4S, CAS 1217487-70-1
5-(2-(1-Fluoro-2-methylpropan-2-yl)pyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 1217487-70-1C12H15FN4S
N-[5-(2-tert-Butyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]acetamide chemical structure, C15H20N4OS, CAS 1217487-75-6
N-[5-(2-tert-Butyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]acetamide
CAS 1217487-75-6C15H20N4OS
5-(2-Isopropylpyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C11H14N4S, CAS 1217487-05-2
5-(2-Isopropylpyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 1217487-05-2C11H14N4S
5-(2-Isobutylpyrimidin-4-yl)-4-methylthiazol-2-amine chemical structure, C12H16N4S, CAS 1217487-14-3
5-(2-Isobutylpyrimidin-4-yl)-4-methylthiazol-2-amine
CAS 1217487-14-3C12H16N4S