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Murcko scaffold

Ring system with 4 rings and 22 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)N1CCN(CC2CC3C=CC2C3)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(CC2CC3C=CC2C3)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

[4-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)piperazin-1-yl](3-fluorophenyl)methanone chemical structure, C19H23FN2O, CAS 1005060-04-7
[4-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)piperazin-1-yl](3-fluorophenyl)methanone
CAS 1005060-04-7C19H23FN2O
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(3-chlorophenyl)methanone chemical structure, C19H23ClN2O, CAS 472981-57-0
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(3-chlorophenyl)methanone
CAS 472981-57-0C19H23ClN2O
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-(2-fluorobenzoyl)piperazine chemical structure, C19H23FN2O, CAS 472981-93-4
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-(2-fluorobenzoyl)piperazine
CAS 472981-93-4C19H23FN2O
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-{4-nitrobenzoyl}piperazine chemical structure, C19H23N3O3, CAS 472981-95-6
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-{4-nitrobenzoyl}piperazine
CAS 472981-95-6C19H23N3O3
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(3-methoxyphenyl)methanone chemical structure, C20H26N2O2, CAS 1005046-56-9
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(3-methoxyphenyl)methanone
CAS 1005046-56-9C20H26N2O2
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C20H26N2O2, CAS 1005273-46-0
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 1005273-46-0C20H26N2O2
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(2,3-dimethoxyphenyl)methanone chemical structure, C21H28N2O3, CAS 1005059-97-1
[4-(5-Bicyclo[2.2.1]hept-2-enylmethyl)piperazin-1-yl]-(2,3-dimethoxyphenyl)methanone
CAS 1005059-97-1C21H28N2O3
[4-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)piperazin-1-yl](3,4,5-trimethoxyphenyl)methanone chemical structure, C22H30N2O4, CAS 1005036-86-1
[4-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)piperazin-1-yl](3,4,5-trimethoxyphenyl)methanone
CAS 1005036-86-1C22H30N2O4
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-(3,4-dimethoxybenzoyl)piperazine chemical structure, C21H28N2O3, CAS 1005060-13-8
1-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-4-(3,4-dimethoxybenzoyl)piperazine
CAS 1005060-13-8C21H28N2O3