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Murcko scaffold

Ring system with 4 rings and 24 atoms

15 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 15
With full pages: 7

Scaffold SMILES

O=C(c1ccco1)N1CCN(c2cnc(-c3ccccc3)o2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(c1ccco1)N1CCN(c2cnc(-c3ccccc3)o2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(4-methoxyphenyl)oxazole-4-carbonitrile chemical structure, C20H18N4O4, CAS 730241-99-3

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(4-methoxyphenyl)oxazole-4-carbonitrile

CAS 730241-99-3C₂₀H₁₈N₄O₄

5-[4-(Furan-2-carbonyl)piperazin-1-yl]-2-phenyl-1,3-oxazole-4-carbonitrile chemical structure, C19H16N4O3, CAS 904509-29-1

5-[4-(Furan-2-carbonyl)piperazin-1-yl]-2-phenyl-1,3-oxazole-4-carbonitrile

CAS 904509-29-1C₁₉H₁₆N₄O₃

2-(4-Chlorophenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C19H15ClN4O3, CAS 903862-06-6

2-(4-Chlorophenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile

CAS 903862-06-6C₁₉H₁₅ClN₄O₃

5-[4-(Furan-2-carbonyl)piperazin-1-yl]-2-(2-methoxyphenyl)-1,3-oxazole-4-carbonitrile chemical structure, C20H18N4O4, CAS 903196-59-8

5-[4-(Furan-2-carbonyl)piperazin-1-yl]-2-(2-methoxyphenyl)-1,3-oxazole-4-carbonitrile

CAS 903196-59-8C₂₀H₁₈N₄O₄

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(3-methoxyphenyl)oxazole-4-carbonitrile chemical structure, C20H18N4O4, CAS 903859-79-0

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(3-methoxyphenyl)oxazole-4-carbonitrile

CAS 903859-79-0C₂₀H₁₈N₄O₄

2-(4-Fluorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15FN4O3, CAS 903193-29-3

2-(4-Fluorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile

CAS 903193-29-3C₁₉H₁₅FN₄O₃

2-(3-Chlorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15ClN4O3, CAS 904500-21-6

2-(3-Chlorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile

CAS 904500-21-6C₁₉H₁₅ClN₄O₃

2-(2-Fluorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15FN4O3, CAS 903867-11-8

2-(2-Fluorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile

CAS 903867-11-8C₁₉H₁₅FN₄O₃

2-(2-Chlorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15ClN4O3, CAS 903197-11-5

2-(2-Chlorophenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile

CAS 903197-11-5C₁₉H₁₅ClN₄O₃

2-(3,4-Dimethoxyphenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C21H20N4O5, CAS 903196-85-0

2-(3,4-Dimethoxyphenyl)-5-[4-(furan-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile

CAS 903196-85-0C₂₁H₂₀N₄O₅

2-(2,4-Dichlorophenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C19H14Cl2N4O3, CAS 905429-19-8

2-(2,4-Dichlorophenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile

CAS 905429-19-8C₁₉H₁₄Cl₂N₄O₃

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(p-tolyl)oxazole-4-carbonitrile chemical structure, C20H18N4O3, CAS 946277-67-4

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(p-tolyl)oxazole-4-carbonitrile

CAS 946277-67-4C₂₀H₁₈N₄O₃

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(m-tolyl)oxazole-4-carbonitrile chemical structure, C20H18N4O3, CAS 946308-45-8

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(m-tolyl)oxazole-4-carbonitrile

CAS 946308-45-8C₂₀H₁₈N₄O₃

2-(4-Ethoxyphenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C21H20N4O4, CAS 946308-69-6

2-(4-Ethoxyphenyl)-5-(4-(furan-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile

CAS 946308-69-6C₂₁H₂₀N₄O₄

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(4-propoxyphenyl)oxazole-4-carbonitrile chemical structure, C22H22N4O4, CAS 946278-15-5

5-(4-(Furan-2-carbonyl)piperazin-1-yl)-2-(4-propoxyphenyl)oxazole-4-carbonitrile

CAS 946278-15-5C₂₂H₂₂N₄O₄