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Murcko scaffold

3-[4-(2-Furoyl)-1-piperazinyl]-1-phenyl-2,5-pyrrolidinedione scaffold

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
10
With full pages
6
Scaffold SMILES

O=C(c1ccco1)N1CCN(C2CC(=O)N(c3ccccc3)C2=O)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-[4-(2-Furoyl)-1-piperazinyl]-1-phenyl-2,5-pyrrolidinedione page
Murcko scaffold O=C(c1ccco1)N1CCN(C2CC(=O)N(c3ccccc3)C2=O)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

3-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C20H21N3O5, CAS 361996-03-4
3-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 361996-03-4C20H21N3O5
1-(4-Fluorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H18FN3O4, CAS 354539-94-9
1-(4-Fluorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 354539-94-9C19H18FN3O4
1-(4-Chlorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H18ClN3O4, CAS 354540-06-0
1-(4-Chlorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 354540-06-0C19H18ClN3O4
1-(3-Chlorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H18ClN3O4, CAS 522637-01-0
1-(3-Chlorophenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 522637-01-0C19H18ClN3O4
1-(3-Ethoxyphenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H23N3O5, CAS 354540-10-6
1-(3-Ethoxyphenyl)-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 354540-10-6C21H23N3O5
3-[4-(Furan-2-ylcarbonyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrolidine-2,5-dione chemical structure, C20H21N3O4, CAS 350707-88-9
3-[4-(Furan-2-ylcarbonyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrolidine-2,5-dione
CAS 350707-88-9C20H21N3O4
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H17ClF3N3O4, CAS 587849-76-1
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[4-(furan-2-carbonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 587849-76-1C20H17ClF3N3O4
3-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione chemical structure, C20H18F3N3O4, CAS 587849-45-4
3-[4-(Furan-2-carbonyl)piperazin-1-yl]-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione
CAS 587849-45-4C20H18F3N3O4
3-[4-(2-Furoyl)-1-piperazinyl]-1-phenyl-2,5-pyrrolidinedione chemical structure, C19H19N3O4, CAS 585558-64-1
3-[4-(2-Furoyl)-1-piperazinyl]-1-phenyl-2,5-pyrrolidinedione
CAS 585558-64-1C19H19N3O4
3-[4-(Furan-2-ylcarbonyl)piperazin-1-yl]-1-(2-methylphenyl)pyrrolidine-2,5-dione chemical structure, C20H21N3O4, CAS 575463-60-4
3-[4-(Furan-2-ylcarbonyl)piperazin-1-yl]-1-(2-methylphenyl)pyrrolidine-2,5-dione
CAS 575463-60-4C20H21N3O4