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Murcko scaffold

Ring system with 4 rings and 24 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
14
With full pages
1
Scaffold SMILES

O=C(c1cccs1)N1CCN(c2cnc(-c3ccccc3)o2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cccs1)N1CCN(c2cnc(-c3ccccc3)o2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

2-(3,4-Dimethoxyphenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C21H20N4O4S, CAS 903195-03-9
2-(3,4-Dimethoxyphenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 903195-03-9C21H20N4O4S
2-(4-Fluorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15FN4O2S, CAS 904500-70-5
2-(4-Fluorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 904500-70-5C19H15FN4O2S
2-(4-Chlorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15ClN4O2S, CAS 903189-69-5
2-(4-Chlorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 903189-69-5C19H15ClN4O2S
2-Phenyl-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H16N4O2S, CAS 903856-16-6
2-Phenyl-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 903856-16-6C19H16N4O2S
2-(2-Methoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C20H18N4O3S, CAS 903203-52-1
2-(2-Methoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 903203-52-1C20H18N4O3S
2-(2-Fluorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C19H15FN4O2S, CAS 904504-87-6
2-(2-Fluorophenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 904504-87-6C19H15FN4O2S
2-(4-Methoxyphenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C20H18N4O3S, CAS 903185-62-6
2-(4-Methoxyphenyl)-5-[4-(thiophene-2-carbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 903185-62-6C20H18N4O3S
2-(2-Chlorophenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C19H15ClN4O2S, CAS 904505-39-1
2-(2-Chlorophenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 904505-39-1C19H15ClN4O2S
2-(3-Methoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C20H18N4O3S, CAS 903195-87-9
2-(3-Methoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 903195-87-9C20H18N4O3S
2-(2,4-Dichlorophenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C19H14Cl2N4O2S, CAS 904010-52-2
2-(2,4-Dichlorophenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 904010-52-2C19H14Cl2N4O2S
2-(4-Methylphenyl)-5-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C20H18N4O2S, CAS 946308-15-2
2-(4-Methylphenyl)-5-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 946308-15-2C20H18N4O2S
2-(3-Methylphenyl)-5-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile chemical structure, C20H18N4O2S, CAS 946377-67-9
2-(3-Methylphenyl)-5-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,3-oxazole-4-carbonitrile
CAS 946377-67-9C20H18N4O2S
2-(4-Ethoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C21H20N4O3S, CAS 946377-90-8
2-(4-Ethoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 946377-90-8C21H20N4O3S
2-(4-Propoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile chemical structure, C22H22N4O3S, CAS 946308-81-2
2-(4-Propoxyphenyl)-5-(4-(thiophene-2-carbonyl)piperazin-1-yl)oxazole-4-carbonitrile
CAS 946308-81-2C22H22N4O3S