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Murcko scaffold

Biphenyl-4-yl[4-(phenylcarbonyl)piperazin-1-yl]methanone scaffold

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
14
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Biphenyl-4-yl[4-(phenylcarbonyl)piperazin-1-yl]methanone page
Murcko scaffold O=C(c1ccccc1)N1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(4-phenylbenzoyl)- chemical structure, C26H26N2O4, CAS 333756-87-9
Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(4-phenylbenzoyl)-
CAS 333756-87-9C26H26N2O4
[4-(2-Methoxybenzoyl)piperazin-1-yl]-(4-phenylphenyl)methanone chemical structure, C25H24N2O3, CAS 462097-84-3
[4-(2-Methoxybenzoyl)piperazin-1-yl]-(4-phenylphenyl)methanone
CAS 462097-84-3C25H24N2O3
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(4-methoxybenzoyl)piperazine chemical structure, C25H24N2O3, CAS 423733-94-2
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(4-methoxybenzoyl)piperazine
CAS 423733-94-2C25H24N2O3
[4-(3-Fluorobenzoyl)piperazin-1-yl]-(4-phenylphenyl)methanone chemical structure, C24H21FN2O2, CAS 423734-64-9
[4-(3-Fluorobenzoyl)piperazin-1-yl]-(4-phenylphenyl)methanone
CAS 423734-64-9C24H21FN2O2
Biphenyl-4-yl{4-[(3,5-dimethoxyphenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C26H26N2O4, CAS 510713-93-6
Biphenyl-4-yl{4-[(3,5-dimethoxyphenyl)carbonyl]piperazin-1-yl}methanone
CAS 510713-93-6C26H26N2O4
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(2,6-dimethoxybenzoyl)piperazine chemical structure, C26H26N2O4, CAS 488827-57-2
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(2,6-dimethoxybenzoyl)piperazine
CAS 488827-57-2C26H26N2O4
Biphenyl-4-yl{4-[(4-nitrophenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C24H21N3O4, CAS 510718-30-6
Biphenyl-4-yl{4-[(4-nitrophenyl)carbonyl]piperazin-1-yl}methanone
CAS 510718-30-6C24H21N3O4
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine chemical structure, C27H28N2O5, CAS 496773-97-8
1-([1,1'-Biphenyl]-4-ylcarbonyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS 496773-97-8C27H28N2O5
Biphenyl-4-yl{4-[(3-methoxyphenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C25H24N2O3, CAS 522650-34-6
Biphenyl-4-yl{4-[(3-methoxyphenyl)carbonyl]piperazin-1-yl}methanone
CAS 522650-34-6C25H24N2O3
Biphenyl-4-yl{4-[(4-fluorophenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C24H21FN2O2, CAS 333756-49-3
Biphenyl-4-yl{4-[(4-fluorophenyl)carbonyl]piperazin-1-yl}methanone
CAS 333756-49-3C24H21FN2O2
Biphenyl-4-yl[4-(phenylcarbonyl)piperazin-1-yl]methanone chemical structure, C24H22N2O2, CAS 333756-69-7
Biphenyl-4-yl[4-(phenylcarbonyl)piperazin-1-yl]methanone
CAS 333756-69-7C24H22N2O2
Biphenyl-4-yl{4-[(2-fluorophenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C24H21FN2O2, CAS 333757-15-6
Biphenyl-4-yl{4-[(2-fluorophenyl)carbonyl]piperazin-1-yl}methanone
CAS 333757-15-6C24H21FN2O2
Biphenyl-4-yl{4-[(2,3-dimethoxyphenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C26H26N2O4, CAS 333757-25-8
Biphenyl-4-yl{4-[(2,3-dimethoxyphenyl)carbonyl]piperazin-1-yl}methanone
CAS 333757-25-8C26H26N2O4
Biphenyl-4-yl{4-[(3-chlorophenyl)carbonyl]piperazin-1-yl}methanone chemical structure, C24H21ClN2O2, CAS 423744-23-4
Biphenyl-4-yl{4-[(3-chlorophenyl)carbonyl]piperazin-1-yl}methanone
CAS 423744-23-4C24H21ClN2O2