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Murcko scaffold

(4-Phenylpiperazino)[1-(phenylsulfonyl)-4-piperidinyl]methanone scaffold

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
18
With full pages
6
Scaffold SMILES

O=C(C1CCN(S(=O)(=O)c2ccccc2)CC1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (4-Phenylpiperazino)[1-(phenylsulfonyl)-4-piperidinyl]methanone page
Murcko scaffold O=C(C1CCN(S(=O)(=O)c2ccccc2)CC1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

[4-(2-Methoxyphenyl)piperazin-1-yl]-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C24H31N3O5S, CAS 593258-63-0
[4-(2-Methoxyphenyl)piperazin-1-yl]-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]methanone
CAS 593258-63-0C24H31N3O5S
[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-(4-phenylpiperazin-1-yl)methanone chemical structure, C23H29N3O4S, CAS 444788-98-1
[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-(4-phenylpiperazin-1-yl)methanone
CAS 444788-98-1C23H29N3O4S
[4-(3-Chlorophenyl)piperazin-1-yl]-[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C25H32ClN3O3S, CAS 695170-59-3
[4-(3-Chlorophenyl)piperazin-1-yl]-[1-(2,4,6-trimethylphenyl)sulfonylpiperidin-4-yl]methanone
CAS 695170-59-3C25H32ClN3O3S
(4-Phenylpiperazin-1-yl)(1-tosylpiperidin-4-yl)methanone chemical structure, C23H29N3O3S, CAS 433706-75-3
(4-Phenylpiperazin-1-yl)(1-tosylpiperidin-4-yl)methanone
CAS 433706-75-3C23H29N3O3S
[1-(4-Fluorophenyl)sulfonylpiperidin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C23H28FN3O4S, CAS 593244-75-8
[1-(4-Fluorophenyl)sulfonylpiperidin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 593244-75-8C23H28FN3O4S
[4-(4-Methoxyphenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C24H31N3O4S, CAS 433974-94-8
[4-(4-Methoxyphenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone
CAS 433974-94-8C24H31N3O4S
(4-Phenylpiperazino)[1-(phenylsulfonyl)-4-piperidinyl]methanone chemical structure, C22H27N3O3S, CAS 478041-49-5
(4-Phenylpiperazino)[1-(phenylsulfonyl)-4-piperidinyl]methanone
CAS 478041-49-5C22H27N3O3S
[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C22H25ClFN3O3S, CAS 433972-18-0
[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 433972-18-0C22H25ClFN3O3S
[4-(2-Fluorophenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C23H28FN3O3S, CAS 768293-60-3
[4-(2-Fluorophenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone
CAS 768293-60-3C23H28FN3O3S
[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C23H28ClN3O4S, CAS 433698-13-6
[1-(4-Chlorophenyl)sulfonylpiperidin-4-yl]-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 433698-13-6C23H28ClN3O4S
{1-[(3,4-Dimethoxyphenyl)sulfonyl]piperidin-4-yl}[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C24H30FN3O5S, CAS 433942-32-6
{1-[(3,4-Dimethoxyphenyl)sulfonyl]piperidin-4-yl}[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 433942-32-6C24H30FN3O5S
[4-(4-Fluorophenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C23H28FN3O3S, CAS 433688-83-6
[4-(4-Fluorophenyl)piperazin-1-yl]-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]methanone
CAS 433688-83-6C23H28FN3O3S
[4-(3-Chlorophenyl)piperazin-1-yl]-[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]methanone chemical structure, C22H25ClFN3O3S, CAS 593261-73-5
[4-(3-Chlorophenyl)piperazin-1-yl]-[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]methanone
CAS 593261-73-5C22H25ClFN3O3S
[1-(4-Ethoxy-3-methylphenyl)sulfonylpiperidin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C25H32FN3O4S, CAS 838893-94-0
[1-(4-Ethoxy-3-methylphenyl)sulfonylpiperidin-4-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 838893-94-0C25H32FN3O4S
1-[1-(4-Chlorobenzenesulfonyl)piperidine-4-carbonyl]-4-phenylpiperazine chemical structure, C22H26ClN3O3S, CAS 848177-68-4
1-[1-(4-Chlorobenzenesulfonyl)piperidine-4-carbonyl]-4-phenylpiperazine
CAS 848177-68-4C22H26ClN3O3S
(1-((4-Fluorophenyl)sulfonyl)piperidin-4-yl)(4-phenylpiperazin-1-yl)methanone chemical structure, C22H26FN3O3S, CAS 591237-99-9
(1-((4-Fluorophenyl)sulfonyl)piperidin-4-yl)(4-phenylpiperazin-1-yl)methanone
CAS 591237-99-9C22H26FN3O3S
1-[1-(4-Methylbenzenesulfonyl)piperidine-4-carbonyl]-4-(4-methylphenyl)piperazine chemical structure, C24H31N3O3S, CAS 1794850-19-3
1-[1-(4-Methylbenzenesulfonyl)piperidine-4-carbonyl]-4-(4-methylphenyl)piperazine
CAS 1794850-19-3C24H31N3O3S
1-(2,4-Dimethylphenyl)-4-[1-(4-methylbenzenesulfonyl)piperidine-4-carbonyl]piperazine chemical structure, C25H33N3O3S, CAS 1794853-22-7
1-(2,4-Dimethylphenyl)-4-[1-(4-methylbenzenesulfonyl)piperidine-4-carbonyl]piperazine
CAS 1794853-22-7C25H33N3O3S