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Murcko scaffold

[4-(Benzenesulfonyl)piperazin-1-yl]-(4-phenylphenyl)methanone scaffold

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(c1ccc(-c2ccccc2)cc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the [4-(Benzenesulfonyl)piperazin-1-yl]-(4-phenylphenyl)methanone page
Murcko scaffold O=C(c1ccc(-c2ccccc2)cc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

Biphenyl-4-yl{4-[(4-methylphenyl)sulfonyl]piperazin-1-yl}methanone chemical structure, C24H24N2O3S, CAS 333756-47-1
Biphenyl-4-yl{4-[(4-methylphenyl)sulfonyl]piperazin-1-yl}methanone
CAS 333756-47-1C24H24N2O3S
Biphenyl-4-yl-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-methanone chemical structure, C24H24N2O4S, CAS 333757-22-5
Biphenyl-4-yl-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-methanone
CAS 333757-22-5C24H24N2O4S
Biphenyl-4-yl{4-[(4-nitrophenyl)sulfonyl]piperazin-1-yl}methanone chemical structure, C23H21N3O5S, CAS 489396-59-0
Biphenyl-4-yl{4-[(4-nitrophenyl)sulfonyl]piperazin-1-yl}methanone
CAS 489396-59-0C23H21N3O5S
N-[4-[4-(4-Phenylbenzoyl)piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C25H25N3O4S, CAS 428849-41-6
N-[4-[4-(4-Phenylbenzoyl)piperazin-1-yl]sulfonylphenyl]acetamide
CAS 428849-41-6C25H25N3O4S
Biphenyl-4-yl{4-[(4-fluorophenyl)sulfonyl]piperazin-1-yl}methanone chemical structure, C23H21FN2O3S, CAS 428835-68-1
Biphenyl-4-yl{4-[(4-fluorophenyl)sulfonyl]piperazin-1-yl}methanone
CAS 428835-68-1C23H21FN2O3S
Biphenyl-4-yl{4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl}methanone chemical structure, C23H21N3O5S, CAS 499209-25-5
Biphenyl-4-yl{4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl}methanone
CAS 499209-25-5C23H21N3O5S
Biphenyl-4-yl{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}methanone chemical structure, C23H21ClN2O3S, CAS 423732-18-7
Biphenyl-4-yl{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}methanone
CAS 423732-18-7C23H21ClN2O3S
[4-(Benzenesulfonyl)piperazin-1-yl]-(4-phenylphenyl)methanone chemical structure, C23H22N2O3S, CAS 518996-40-2
[4-(Benzenesulfonyl)piperazin-1-yl]-(4-phenylphenyl)methanone
CAS 518996-40-2C23H22N2O3S
MMP-9/MMP-13 Inhibitor I chemical structure, C25H25N3O6S, CAS 204140-01-2
MMP-9/MMP-13 Inhibitor I
CAS 204140-01-2C25H25N3O6S