CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 25 atoms

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
34
With full pages
16
Scaffold SMILES

O=C(CC1C(=O)NCCN1C(=O)c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)NCCN1C(=O)c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(4-fluorophenyl)acetamide chemical structure, C19H18FN3O3, CAS 1009184-09-1
2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(4-fluorophenyl)acetamide
CAS 1009184-09-1C19H18FN3O3
2-(1-(4-Fluorobenzoyl)-3-oxopiperazin-2-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C20H20FN3O4, CAS 700347-55-3
2-(1-(4-Fluorobenzoyl)-3-oxopiperazin-2-yl)-N-(4-methoxyphenyl)acetamide
CAS 700347-55-3C20H20FN3O4
2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(3-chlorophenyl)acetamide chemical structure, C19H18ClN3O3, CAS 1008658-03-4
2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(3-chlorophenyl)acetamide
CAS 1008658-03-4C19H18ClN3O3
2-[1-(4-Methoxybenzoyl)-3-oxopiperazin-2-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H23N3O4, CAS 1009523-51-6
2-[1-(4-Methoxybenzoyl)-3-oxopiperazin-2-yl]-N-(4-methylphenyl)acetamide
CAS 1009523-51-6C21H23N3O4
N-(4-Ethoxyphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide chemical structure, C21H23N3O4, CAS 1008639-67-5
N-(4-Ethoxyphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide
CAS 1008639-67-5C21H23N3O4
N-(3,4-Dimethylphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C22H25N3O4, CAS 1008984-54-0
N-(3,4-Dimethylphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1008984-54-0C22H25N3O4
2-{1-[(4-Chlorophenyl)carbonyl]-3-oxopiperazin-2-yl}-N-(4-ethoxyphenyl)acetamide chemical structure, C21H22ClN3O4, CAS 1008958-04-0
2-{1-[(4-Chlorophenyl)carbonyl]-3-oxopiperazin-2-yl}-N-(4-ethoxyphenyl)acetamide
CAS 1008958-04-0C21H22ClN3O4
Dimethyl 5-{[(1-benzoyl-3-oxo-2-piperazinyl)acetyl]amino}isophthalate chemical structure, C23H23N3O7, CAS 1042693-31-1
Dimethyl 5-{[(1-benzoyl-3-oxo-2-piperazinyl)acetyl]amino}isophthalate
CAS 1042693-31-1C23H23N3O7
N-(2,3-Dichlorophenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C20H19Cl2N3O4, CAS 1042694-13-2
N-(2,3-Dichlorophenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1042694-13-2C20H19Cl2N3O4
2-[1-(3-Chlorobenzoyl)-3-oxopiperazin-2-yl]-N-(2-methylphenyl)acetamide chemical structure, C20H20ClN3O3, CAS 1009240-65-6
2-[1-(3-Chlorobenzoyl)-3-oxopiperazin-2-yl]-N-(2-methylphenyl)acetamide
CAS 1009240-65-6C20H20ClN3O3
N-(3-Chlorophenyl)-2-[1-(4-nitrobenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C19H17ClN4O5, CAS 1009709-40-3
N-(3-Chlorophenyl)-2-[1-(4-nitrobenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1009709-40-3C19H17ClN4O5
N-(2,5-Dimethoxyphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide chemical structure, C21H23N3O5, CAS 1008009-44-6
N-(2,5-Dimethoxyphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide
CAS 1008009-44-6C21H23N3O5
2-[1-(4-Methylbenzoyl)-3-oxopiperazin-2-yl]-N-phenylacetamide chemical structure, C20H21N3O3, CAS 1009496-61-0
2-[1-(4-Methylbenzoyl)-3-oxopiperazin-2-yl]-N-phenylacetamide
CAS 1009496-61-0C20H21N3O3
2-[1-(4-Fluorobenzoyl)-3-oxopiperazin-2-yl]-N-(4-methylphenyl)acetamide chemical structure, C20H20FN3O3, CAS 1008704-39-9
2-[1-(4-Fluorobenzoyl)-3-oxopiperazin-2-yl]-N-(4-methylphenyl)acetamide
CAS 1008704-39-9C20H20FN3O3
N-(3-Chlorophenyl)-2-[1-(3-methylbenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C20H20ClN3O3, CAS 1008965-08-9
N-(3-Chlorophenyl)-2-[1-(3-methylbenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1008965-08-9C20H20ClN3O3
2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C20H21N3O4, CAS 1008239-95-9
2-(1-Benzoyl-3-oxopiperazin-2-yl)-N-(3-methoxyphenyl)acetamide
CAS 1008239-95-9C20H21N3O4
2-{1-[(4-Fluorophenyl)carbonyl]-3-oxopiperazin-2-yl}-N-(3-methoxyphenyl)acetamide chemical structure, C20H20FN3O4, CAS 1009236-07-0
2-{1-[(4-Fluorophenyl)carbonyl]-3-oxopiperazin-2-yl}-N-(3-methoxyphenyl)acetamide
CAS 1009236-07-0C20H20FN3O4
N-(5-Chloro-2-methoxyphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C21H22ClN3O5, CAS 1009227-09-1
N-(5-Chloro-2-methoxyphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1009227-09-1C21H22ClN3O5
2-[1-(2-Methoxybenzoyl)-3-oxopiperazin-2-yl]-N-(3-methylphenyl)acetamide chemical structure, C21H23N3O4, CAS 1009162-74-6
2-[1-(2-Methoxybenzoyl)-3-oxopiperazin-2-yl]-N-(3-methylphenyl)acetamide
CAS 1009162-74-6C21H23N3O4
Dimethyl 5-[({1-[(4-fluorophenyl)carbonyl]-3-oxopiperazin-2-yl}acetyl)amino]benzene-1,3-dicarboxylate chemical structure, C23H22FN3O7, CAS 1031305-80-2
Dimethyl 5-[({1-[(4-fluorophenyl)carbonyl]-3-oxopiperazin-2-yl}acetyl)amino]benzene-1,3-dicarboxylate
CAS 1031305-80-2C23H22FN3O7
N-(5-Chloro-2-methylphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide chemical structure, C20H20ClN3O3, CAS 1009262-42-3
N-(5-Chloro-2-methylphenyl)-2-[3-oxo-1-(phenylcarbonyl)piperazin-2-yl]acetamide
CAS 1009262-42-3C20H20ClN3O3
N-(4-Ethylphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C22H25N3O4, CAS 1008239-63-1
N-(4-Ethylphenyl)-2-[1-(4-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1008239-63-1C22H25N3O4
N-(4-Ethylphenyl)-2-[1-(2-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C22H25N3O4, CAS 1008445-73-5
N-(4-Ethylphenyl)-2-[1-(2-methoxybenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1008445-73-5C22H25N3O4
N-(4-Ethylphenyl)-2-[1-(4-fluorobenzoyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C21H22FN3O3, CAS 1009336-48-4
N-(4-Ethylphenyl)-2-[1-(4-fluorobenzoyl)-3-oxopiperazin-2-yl]acetamide
CAS 1009336-48-4C21H22FN3O3