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Murcko scaffold

Ring system with 4 rings and 19 atoms

22 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 19
Chemicals: 22
With full pages: 8

Scaffold SMILES

O=C1Nc2ccccc2C1c1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1Nc2ccccc2C1c1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

3'-Hydroxy-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one chemical structure, C16H12N2O2, CAS 33333-60-7

3'-Hydroxy-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one

CAS 33333-60-7C₁₆H₁₂N₂O₂

Ethyl 2-(3-hydroxy-3-(1H-indol-3-yl)-2-oxoindolin-1-yl)acetate chemical structure, C20H18N2O4, CAS 676612-32-1

Ethyl 2-(3-hydroxy-3-(1H-indol-3-yl)-2-oxoindolin-1-yl)acetate

CAS 676612-32-1C₂₀H₁₈N₂O₄

3-Hydroxy-3-(1H-indol-3-yl)-1-propylindol-2-one chemical structure, C19H18N2O2, CAS 676612-31-0

3-Hydroxy-3-(1H-indol-3-yl)-1-propylindol-2-one

CAS 676612-31-0C₁₉H₁₈N₂O₂

5-Bromo-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indol-2-one chemical structure, C18H15BrN2O2, CAS 676612-44-5

5-Bromo-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indol-2-one

CAS 676612-44-5C₁₈H₁₅BrN₂O₂

5-Chloro-3-hydroxy-3-(2-methyl-1H-indol-3-yl)-1H-indol-2-one chemical structure, C17H13ClN2O2, CAS 676612-62-7

5-Chloro-3-hydroxy-3-(2-methyl-1H-indol-3-yl)-1H-indol-2-one

CAS 676612-62-7C₁₇H₁₃ClN₂O₂

3-Hydroxy-3-(2-methyl-1H-indol-3-yl)-1-propan-2-ylindol-2-one chemical structure, C20H20N2O2, CAS 688038-08-6

3-Hydroxy-3-(2-methyl-1H-indol-3-yl)-1-propan-2-ylindol-2-one

CAS 688038-08-6C₂₀H₂₀N₂O₂

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-methylindol-2-one chemical structure, C17H13ClN2O2, CAS 688037-94-7

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-methylindol-2-one

CAS 688037-94-7C₁₇H₁₃ClN₂O₂

3'-Hydroxy-7'-methyl-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one chemical structure, C17H14N2O2, CAS 688037-97-0

3'-Hydroxy-7'-methyl-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one

CAS 688037-97-0C₁₇H₁₄N₂O₂

5'-Bromo-1'-ethyl-3'-hydroxy-2-methyl-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one chemical structure, C19H17BrN2O2, CAS 688038-20-2

5'-Bromo-1'-ethyl-3'-hydroxy-2-methyl-1',3'-dihydro-1H,2'H-3,3'-biindol-2'-one

CAS 688038-20-2C₁₉H₁₇BrN₂O₂

3-Hydroxy-5-methyl-3-(2-methyl-1H-indol-3-yl)-1H-indol-2-one chemical structure, C18H16N2O2, CAS 688037-98-1

3-Hydroxy-5-methyl-3-(2-methyl-1H-indol-3-yl)-1H-indol-2-one

CAS 688037-98-1C₁₈H₁₆N₂O₂

Ethyl (3-hydroxy-2'-methyl-2-oxo-2,3-dihydro-1H,1'H-3,3'-biindol-1-yl)acetate chemical structure, C21H20N2O4, CAS 688038-05-3

Ethyl (3-hydroxy-2'-methyl-2-oxo-2,3-dihydro-1H,1'H-3,3'-biindol-1-yl)acetate

CAS 688038-05-3C₂₁H₂₀N₂O₄

3-Hydroxy-1,7-dimethyl-3-(2-methyl-1H-indol-3-yl)-5-nitroindol-2-one chemical structure, C19H17N3O4, CAS 701257-16-1

3-Hydroxy-1,7-dimethyl-3-(2-methyl-1H-indol-3-yl)-5-nitroindol-2-one

CAS 701257-16-1C₁₉H₁₇N₃O₄

5-Chloro-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indol-2-one chemical structure, C18H15ClN2O2, CAS 717836-99-2

5-Chloro-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indol-2-one

CAS 717836-99-2C₁₈H₁₅ClN₂O₂

3-Hydroxy-3-(1H-indol-3-yl)-4,6-dimethyl-1H-indol-2-one chemical structure, C18H16N2O2, CAS 688038-73-5

3-Hydroxy-3-(1H-indol-3-yl)-4,6-dimethyl-1H-indol-2-one

CAS 688038-73-5C₁₈H₁₆N₂O₂

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-propylindol-2-one chemical structure, C19H17ClN2O2, CAS 838895-91-3

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-propylindol-2-one

CAS 838895-91-3C₁₉H₁₇ClN₂O₂

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-prop-2-enylindol-2-one chemical structure, C19H15ClN2O2, CAS 838896-97-2

5-Chloro-3-hydroxy-3-(1H-indol-3-yl)-1-prop-2-enylindol-2-one

CAS 838896-97-2C₁₉H₁₅ClN₂O₂

Methyl 2-(3-hydroxy-3-(2-methyl-1H-indol-3-yl)-2-oxoindolin-1-yl)acetate chemical structure, C20H18N2O4, CAS 688038-19-9

Methyl 2-(3-hydroxy-3-(2-methyl-1H-indol-3-yl)-2-oxoindolin-1-yl)acetate

CAS 688038-19-9C₂₀H₁₈N₂O₄

5-Ethyl-3-hydroxy-3-(1H-indol-3-yl)-1H-indol-2-one chemical structure, C18H16N2O2, CAS 839689-03-1

5-Ethyl-3-hydroxy-3-(1H-indol-3-yl)-1H-indol-2-one

CAS 839689-03-1C₁₈H₁₆N₂O₂

3-Hydroxy-3-(1H-indol-3-yl)-1-(2-methylprop-2-enyl)indol-2-one chemical structure, C20H18N2O2, CAS 842115-88-2

3-Hydroxy-3-(1H-indol-3-yl)-1-(2-methylprop-2-enyl)indol-2-one

CAS 842115-88-2C₂₀H₁₈N₂O₂

3-Hydroxy-3-(1H-indol-3-yl)-1-prop-2-enylindol-2-one chemical structure, C19H16N2O2, CAS 676612-29-6

3-Hydroxy-3-(1H-indol-3-yl)-1-prop-2-enylindol-2-one

CAS 676612-29-6C₁₉H₁₆N₂O₂

3-Hydroxy-3-(2-methyl-1H-indol-3-yl)-1-propylindol-2-one chemical structure, C20H20N2O2, CAS 688038-04-2

3-Hydroxy-3-(2-methyl-1H-indol-3-yl)-1-propylindol-2-one

CAS 688038-04-2C₂₀H₂₀N₂O₂

3-Hydroxy-5-iodo[3,3a(2)-bi-1H-indol]-2(3H)-one chemical structure, C16H11IN2O2, CAS 1621376-10-0

3-Hydroxy-5-iodo[3,3a(2)-bi-1H-indol]-2(3H)-one

CAS 1621376-10-0C₁₆H₁₁IN₂O₂