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Murcko scaffold

Ring system with 4 rings and 26 atoms

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
17
With full pages
1
Scaffold SMILES

c1ccc(CCn2c(-c3ccccc3)csc2=Nc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CCn2c(-c3ccccc3)csc2=Nc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

(Z)-2-(4-(4-Methoxyphenyl)-2-(phenylimino)thiazol-3(2H)-yl)-1-(4-nitrophenyl)ethanol chemical structure, C24H21N3O4S, CAS 298194-53-3
(Z)-2-(4-(4-Methoxyphenyl)-2-(phenylimino)thiazol-3(2H)-yl)-1-(4-nitrophenyl)ethanol
CAS 298194-53-3C24H21N3O4S
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]aniline chemical structure, C26H26N2O2S, CAS 488725-38-8
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]aniline
CAS 488725-38-8C26H26N2O2S
N-(4-(4-Chlorophenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene)aniline chemical structure, C23H19ClN2S, CAS 372970-31-5
N-(4-(4-Chlorophenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene)aniline
CAS 372970-31-5C23H19ClN2S
N-[(2Z)-4-(4-Methylphenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene]aniline chemical structure, C24H22N2S, CAS 341498-87-1
N-[(2Z)-4-(4-Methylphenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene]aniline
CAS 341498-87-1C24H22N2S
3-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(phenylimino)-2,3-dihydro-1,3-thiazol-4-yl]-N,N-dimethylbenzenesulfonamide chemical structure, C27H29N3O4S2, CAS 845799-59-9
3-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(phenylimino)-2,3-dihydro-1,3-thiazol-4-yl]-N,N-dimethylbenzenesulfonamide
CAS 845799-59-9C27H29N3O4S2
N-[(2Z)-4-(4-Chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-thiazol-2(3H)-ylidene]-4-ethoxyaniline chemical structure, C27H27ClN2O3S, CAS 850899-65-9
N-[(2Z)-4-(4-Chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-thiazol-2(3H)-ylidene]-4-ethoxyaniline
CAS 850899-65-9C27H27ClN2O3S
Benzenamine, 2-chloro-N-[4-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-2(3H)-thiazolylidene] chemical structure, C24H19ClF2N2OS, CAS 1049986-21-1
Benzenamine, 2-chloro-N-[4-[4-(difluoromethoxy)phenyl]-3-(2-phenylethyl)-2(3H)-thiazolylidene]
CAS 1049986-21-1C24H19ClF2N2OS
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]-4-ethoxyaniline chemical structure, C28H30N2O4S, CAS 877801-56-4
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]-4-ethoxyaniline
CAS 877801-56-4C28H30N2O4S
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline chemical structure, C27H28N2O4S, CAS 877786-22-6
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline
CAS 877786-22-6C27H28N2O4S
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline chemical structure, C27H28N2O3S, CAS 877622-25-8
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline
CAS 877622-25-8C27H28N2O3S
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-phenyl-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline chemical structure, C26H26N2O3S, CAS 861813-23-2
N-[(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-phenyl-1,3-thiazol-2(3H)-ylidene]-4-methoxyaniline
CAS 861813-23-2C26H26N2O3S
4-Ethoxy-N-[(2Z)-4-(4-methoxyphenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene]aniline chemical structure, C26H26N2O2S, CAS 849828-23-5
4-Ethoxy-N-[(2Z)-4-(4-methoxyphenyl)-3-(2-phenylethyl)-1,3-thiazol-2(3H)-ylidene]aniline
CAS 849828-23-5C26H26N2O2S
(Z)-1-(4-Nitrophenyl)-2-(4-phenyl-2-(phenylimino)thiazol-3(2H)-yl)ethanol chemical structure, C23H19N3O3S, CAS 24288-73-1
(Z)-1-(4-Nitrophenyl)-2-(4-phenyl-2-(phenylimino)thiazol-3(2H)-yl)ethanol
CAS 24288-73-1C23H19N3O3S
4-{(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-[(4-methylphenyl)imino]-2,3-dihydro-1,3-thiazol-4-yl}-N,N-diethylbenzenesulfonamide chemical structure, C30H35N3O4S2, CAS 850902-56-6
4-{(2Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-[(4-methylphenyl)imino]-2,3-dihydro-1,3-thiazol-4-yl}-N,N-diethylbenzenesulfonamide
CAS 850902-56-6C30H35N3O4S2
2-[4-(4-Methylphenyl)-2-phenylimino-1,3-thiazol-3-yl]-1-(4-nitrophenyl)ethanol chemical structure, C24H21N3O3S, CAS 328106-73-6
2-[4-(4-Methylphenyl)-2-phenylimino-1,3-thiazol-3-yl]-1-(4-nitrophenyl)ethanol
CAS 328106-73-6C24H21N3O3S
N,N-Dimethyl-4-(3-phenethyl-2-phenylimino-1,3-thiazol-4-yl)benzenesulfonamide chemical structure, C25H25N3O2S2, CAS 7026-97-3
N,N-Dimethyl-4-(3-phenethyl-2-phenylimino-1,3-thiazol-4-yl)benzenesulfonamide
CAS 7026-97-3C25H25N3O2S2
4-[3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-phenylimino-1,3-thiazol-4-yl]-N,N-dimethylbenzenesulfonamide chemical structure, C27H29N3O4S2, CAS 7026-98-4
4-[3-[2-(3,4-Dimethoxyphenyl)ethyl]-2-phenylimino-1,3-thiazol-4-yl]-N,N-dimethylbenzenesulfonamide
CAS 7026-98-4C27H29N3O4S2