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Murcko scaffold

Ring system with 4 rings and 22 atoms

26 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 26
With full pages: 3

Scaffold SMILES

c1ccc(OCc2nnc3sc(-c4ccccc4)nn23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(OCc2nnc3sc(-c4ccccc4)nn23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

6-(3-Chlorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H11ClN4OS, CAS 573932-39-5

6-(3-Chlorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 573932-39-5C₁₆H₁₁ClN₄OS

3-(Phenoxymethyl)-6-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C19H18N4O4S, CAS 575459-62-0

3-(Phenoxymethyl)-6-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 575459-62-0C₁₉H₁₈N₄O₄S

6-(3,4-Dimethoxyphenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H16N4O3S, CAS 227945-50-8

6-(3,4-Dimethoxyphenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 227945-50-8C₁₈H₁₆N₄O₃S

6-(4-Chlorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H11ClN4OS, CAS 113766-07-7

6-(4-Chlorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 113766-07-7C₁₆H₁₁ClN₄OS

6-(2-Methylphenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C17H14N4OS, CAS 586995-17-7

6-(2-Methylphenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 586995-17-7C₁₇H₁₄N₄OS

6-(3-Fluorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H11FN4OS, CAS 708291-13-8

6-(3-Fluorophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 708291-13-8C₁₆H₁₁FN₄OS

6-(4-Bromophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H11BrN4OS, CAS 723737-77-7

6-(4-Bromophenyl)-3-(phenoxymethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 723737-77-7C₁₆H₁₁BrN₄OS

6-(4-Ethoxyphenyl)-3-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H16N4O2S, CAS 709002-45-9

6-(4-Ethoxyphenyl)-3-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 709002-45-9C₁₈H₁₆N₄O₂S

6-(2,5-Dichlorophenyl)-3-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H10Cl2N4OS, CAS 708279-64-5

6-(2,5-Dichlorophenyl)-3-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 708279-64-5C₁₆H₁₀Cl₂N₄OS

3-[(4-Fluorophenoxy)methyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H11FN4OS, CAS 904010-34-0

3-[(4-Fluorophenoxy)methyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 904010-34-0C₁₆H₁₁FN₄OS

6-(4-Methoxyphenyl)-3-[(4-methylphenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H16N4O2S, CAS 874464-18-3

6-(4-Methoxyphenyl)-3-[(4-methylphenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 874464-18-3C₁₈H₁₆N₄O₂S

3-[(3-Methylphenoxy)methyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C17H14N4OS, CAS 874463-79-3

3-[(3-Methylphenoxy)methyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 874463-79-3C₁₇H₁₄N₄OS

6-(4-Methoxyphenyl)-3-[(3-methylphenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H16N4O2S, CAS 874463-80-6

6-(4-Methoxyphenyl)-3-[(3-methylphenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 874463-80-6C₁₈H₁₆N₄O₂S

3-[(4-Chlorophenoxy)methyl]-6-(3,4-dimethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H15ClN4O3S, CAS 874463-86-2

3-[(4-Chlorophenoxy)methyl]-6-(3,4-dimethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 874463-86-2C₁₈H₁₅ClN₄O₃S

3-[(4-Fluorophenoxy)methyl]-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C17H13FN4O2S, CAS 904511-60-0

3-[(4-Fluorophenoxy)methyl]-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 904511-60-0C₁₇H₁₃FN₄O₂S

6-(4-Chlorophenyl)-3-[(4-fluorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H10ClFN4OS, CAS 904007-76-7

6-(4-Chlorophenyl)-3-[(4-fluorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 904007-76-7C₁₆H₁₀ClFN₄OS

4-[3-[(4-Fluorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-N,N-dimethylaniline chemical structure, C18H16FN5OS, CAS 892687-65-9

4-[3-[(4-Fluorophenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-N,N-dimethylaniline

CAS 892687-65-9C₁₈H₁₆FN₅OS

6-(3,4-Dimethoxyphenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H15FN4O3S, CAS 903191-21-9

6-(3,4-Dimethoxyphenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 903191-21-9C₁₈H₁₅FN₄O₃S

3-[(4-Fluorophenoxy)methyl]-6-(3,4,5-trimethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C19H17FN4O4S, CAS 903864-12-0

3-[(4-Fluorophenoxy)methyl]-6-(3,4,5-trimethoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 903864-12-0C₁₉H₁₇FN₄O₄S

6-(2,4-Dimethoxyphenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H15FN4O3S, CAS 903197-22-8

6-(2,4-Dimethoxyphenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 903197-22-8C₁₈H₁₅FN₄O₃S

6-(2,4-Dichlorophenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H9Cl2FN4OS, CAS 892686-96-3

6-(2,4-Dichlorophenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 892686-96-3C₁₆H₉Cl₂FN₄OS

6-(3-Bromo-4-fluorophenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C16H9BrF2N4OS, CAS 929856-86-0

6-(3-Bromo-4-fluorophenyl)-3-[(4-fluorophenoxy)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 929856-86-0C₁₆H₉BrF₂N₄OS

3-[(4-Methoxyphenoxy)methyl]-6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C17H14N4O2S, CAS 950256-01-6

3-[(4-Methoxyphenoxy)methyl]-6-phenyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 950256-01-6C₁₇H₁₄N₄O₂S

3-[(4-Methoxyphenoxy)methyl]-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole chemical structure, C18H16N4O3S, CAS 1082767-63-2

3-[(4-Methoxyphenoxy)methyl]-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

CAS 1082767-63-2C₁₈H₁₆N₄O₃S