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Murcko scaffold

Ring system with 4 rings and 21 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
14
With full pages
3
Scaffold SMILES

O=C(c1cc2ccccc2[nH]1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2ccccc2[nH]1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

3,4-Dihydroisoquinolin-2(1H)-yl(5-fluoro-1H-indol-2-yl)methanone chemical structure, C18H15FN2O, CAS 902045-22-1
3,4-Dihydroisoquinolin-2(1H)-yl(5-fluoro-1H-indol-2-yl)methanone
CAS 902045-22-1C18H15FN2O
(5-Chloro-1H-indol-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C18H15ClN2O, CAS 900257-00-3
(5-Chloro-1H-indol-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 900257-00-3C18H15ClN2O
3,4-Dihydroisoquinolin-2(1H)-yl(5-methoxy-3-methyl-1H-indol-2-yl)methanone chemical structure, C20H20N2O2, CAS 902321-61-3
3,4-Dihydroisoquinolin-2(1H)-yl(5-methoxy-3-methyl-1H-indol-2-yl)methanone
CAS 902321-61-3C20H20N2O2
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(1-methyl-1H-indol-2-yl)methanone chemical structure, C21H22N2O3, CAS 1246056-17-6
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(1-methyl-1H-indol-2-yl)methanone
CAS 1246056-17-6C21H22N2O3
{[2-(5-Chloro-1-methyl-1H-indole-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]methyl}dimethylamine chemical structure, C22H24ClN3O, CAS 1253660-12-6
{[2-(5-Chloro-1-methyl-1H-indole-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]methyl}dimethylamine
CAS 1253660-12-6C22H24ClN3O
3,4-Dihydroisoquinolin-2(1H)-yl(5-fluoro-1-methyl-1H-indol-2-yl)methanone chemical structure, C19H17FN2O, CAS 1374531-49-3
3,4-Dihydroisoquinolin-2(1H)-yl(5-fluoro-1-methyl-1H-indol-2-yl)methanone
CAS 1374531-49-3C19H17FN2O
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(5-fluoro-1-methyl-1H-indol-2-yl)methanone chemical structure, C21H21FN2O3, CAS 1374528-02-5
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(5-fluoro-1-methyl-1H-indol-2-yl)methanone
CAS 1374528-02-5C21H21FN2O3
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4,7-dimethoxy-1-methyl-1H-indol-2-yl)methanone chemical structure, C23H26N2O5, CAS 1351690-89-5
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4,7-dimethoxy-1-methyl-1H-indol-2-yl)methanone
CAS 1351690-89-5C23H26N2O5
3,4-Dihydroisoquinolin-2(1H)-yl(4,7-dimethoxy-1-methyl-1H-indol-2-yl)methanone chemical structure, C21H22N2O3, CAS 1351703-31-5
3,4-Dihydroisoquinolin-2(1H)-yl(4,7-dimethoxy-1-methyl-1H-indol-2-yl)methanone
CAS 1351703-31-5C21H22N2O3
[5-Chloro-1-(2-methoxyethyl)-1H-indol-2-yl](6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C23H25ClN2O4, CAS 1435988-05-8
[5-Chloro-1-(2-methoxyethyl)-1H-indol-2-yl](6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 1435988-05-8C23H25ClN2O4
(4-Chloro-1H-indol-2-yl)(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C20H19ClN2O3, CAS 1574496-60-8
(4-Chloro-1H-indol-2-yl)(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 1574496-60-8C20H19ClN2O3
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4,7-dimethoxy-1H-indol-2-yl)methanone chemical structure, C22H24N2O5, CAS 1574477-85-2
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4,7-dimethoxy-1H-indol-2-yl)methanone
CAS 1574477-85-2C22H24N2O5
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(5-methoxy-1H-indol-2-yl)methanone chemical structure, C21H22N2O4, CAS 1574391-54-0
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(5-methoxy-1H-indol-2-yl)methanone
CAS 1574391-54-0C21H22N2O4
(6-Chloro-1-methyl-1H-indol-2-yl)(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone chemical structure, C21H21ClN2O3, CAS 1630840-47-9
(6-Chloro-1-methyl-1H-indol-2-yl)(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone
CAS 1630840-47-9C21H21ClN2O3