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Murcko scaffold

3-Phenylpiperazin-2-one scaffold

211 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
211
With full pages
14
Scaffold SMILES

O=C1NCCNC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenylpiperazin-2-one page
Murcko scaffold O=C1NCCNC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 211 chemicals

4-Ethyl-3-phenylpiperazin-2-one chemical structure, C12H16N2O, CAS 5368-21-8
4-Ethyl-3-phenylpiperazin-2-one
CAS 5368-21-8C12H16N2O
4-Methyl-3-phenylpiperazin-2-one chemical structure, C11H14N2O, CAS 5368-20-7
4-Methyl-3-phenylpiperazin-2-one
CAS 5368-20-7C11H14N2O
3-Phenylpiperazin-2-one chemical structure, C10H12N2O, CAS 5368-28-5
3-Phenylpiperazin-2-one
CAS 5368-28-5C10H12N2O
4-Acetyl-3-phenylpiperazin-2-one chemical structure, C12H14N2O2, CAS 5368-25-2
4-Acetyl-3-phenylpiperazin-2-one
CAS 5368-25-2C12H14N2O2
4-Nitroso-3-phenylpiperazin-2-one chemical structure, C10H11N3O2, CAS 958819-61-9
4-Nitroso-3-phenylpiperazin-2-one
CAS 958819-61-9C10H11N3O2
3-(4-Methoxyphenyl)piperazin-2-one chemical structure, C11H14N2O2, CAS 85607-62-1
3-(4-Methoxyphenyl)piperazin-2-one
CAS 85607-62-1C11H14N2O2
3-(4-Methylphenyl)piperazin-2-one chemical structure, C11H14N2O, CAS 157977-91-8
3-(4-Methylphenyl)piperazin-2-one
CAS 157977-91-8C11H14N2O
1-Methyl-3-phenylpiperazin-2-one chemical structure, C11H14N2O, CAS 799796-66-0
1-Methyl-3-phenylpiperazin-2-one
CAS 799796-66-0C11H14N2O
3-Phenyl-4-(prop-2-enoyl)piperazin-2-one chemical structure, C13H14N2O2, CAS 63235-19-8
3-Phenyl-4-(prop-2-enoyl)piperazin-2-one
CAS 63235-19-8C13H14N2O2
3-(3,4-Dimethoxy-phenyl)-piperazin-2-one chemical structure, C12H16N2O3, CAS 85606-95-7
3-(3,4-Dimethoxy-phenyl)-piperazin-2-one
CAS 85606-95-7C12H16N2O3
3-(4-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 85606-96-8
3-(4-Fluorophenyl)piperazin-2-one
CAS 85606-96-8C10H11FN2O
3-[4-(2-Methoxyethoxy)phenyl]-2-piperazinone chemical structure, C13H18N2O3, CAS 85607-63-2
3-[4-(2-Methoxyethoxy)phenyl]-2-piperazinone
CAS 85607-63-2C13H18N2O3
3-(4-(Trifluoromethyl)phenyl)piperazin-2-one chemical structure, C11H11F3N2O, CAS 185110-29-6
3-(4-(Trifluoromethyl)phenyl)piperazin-2-one
CAS 185110-29-6C11H11F3N2O
(S)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one chemical structure, C11H13FN2O, CAS 334477-18-8
(S)-3-(4-Fluoro-2-methylphenyl)piperazin-2-one
CAS 334477-18-8C11H13FN2O
3-(3-Methoxy-phenyl)-piperazin-2-one chemical structure, C11H14N2O2, CAS 1228561-20-3
3-(3-Methoxy-phenyl)-piperazin-2-one
CAS 1228561-20-3C11H14N2O2
3-(2-Methylphenyl)piperazin-2-one chemical structure, C11H14N2O, CAS 1246548-82-2
3-(2-Methylphenyl)piperazin-2-one
CAS 1246548-82-2C11H14N2O
3-(4-Fluoro-2-methylphenyl)piperazin-2-one chemical structure, C11H13FN2O, CAS 334477-68-8
3-(4-Fluoro-2-methylphenyl)piperazin-2-one
CAS 334477-68-8C11H13FN2O
3-(3,4-Dichlorophenyl)piperazin-2-one chemical structure, C10H10Cl2N2O, CAS 334477-10-0
3-(3,4-Dichlorophenyl)piperazin-2-one
CAS 334477-10-0C10H10Cl2N2O
3-(2,4-Dichloro-phenyl)-piperazin-2-one chemical structure, C10H10Cl2N2O, CAS 1228557-49-0
3-(2,4-Dichloro-phenyl)-piperazin-2-one
CAS 1228557-49-0C10H10Cl2N2O
(S)-3-(4-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 1228566-24-2
(S)-3-(4-Fluorophenyl)piperazin-2-one
CAS 1228566-24-2C10H11FN2O
(R)-3-(4-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 1228550-49-9
(R)-3-(4-Fluorophenyl)piperazin-2-one
CAS 1228550-49-9C10H11FN2O
(S)-3-(3-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 1228559-12-3
(S)-3-(3-Fluorophenyl)piperazin-2-one
CAS 1228559-12-3C10H11FN2O
(3R)-3-(3-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 1228568-49-7
(3R)-3-(3-Fluorophenyl)piperazin-2-one
CAS 1228568-49-7C10H11FN2O
(S)-3-Phenylpiperazin-2-one chemical structure, C10H12N2O, CAS 1240585-52-7
(S)-3-Phenylpiperazin-2-one
CAS 1240585-52-7C10H12N2O