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Murcko scaffold

Ring system with 3 rings and 30 atoms

27 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 30
Chemicals: 27
With full pages: 5

Scaffold SMILES

O=C(NC1CCCCC1)NS(=O)(=O)c1ccc(CCNC(=O)c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NC1CCCCC1)NS(=O)(=O)c1ccc(CCNC(=O)c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

Glibenclamide chemical structure, C23H28ClN3O5S, CAS 10238-21-8

CAS 10238-21-8C₂₃H₂₈ClN₃O₅S

5-Iodo-2-hydroxyglyburide chemical structure, C22H26IN3O5S, CAS 128836-54-4

5-Iodo-2-hydroxyglyburide

CAS 128836-54-4C₂₂H₂₆IN₃O₅S

N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-iodo-2-methoxybenzamide chemical structure, C23H28IN3O5S, CAS 16789-77-8

N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-iodo-2-methoxybenzamide

CAS 16789-77-8C₂₃H₂₈IN₃O₅S

Glyburide mixture with Metformin hydrochloride chemical structure, C27H40Cl2N8O5S, CAS 338752-31-1

Glyburide mixture with Metformin hydrochloride

CAS 338752-31-1C₂₇H₄₀Cl₂N₈O₅S

5-Chloro-N-(2-(4-(((((3-hydroxycyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide chemical structure, C23H28ClN3O6S, CAS 23074-07-9

5-Chloro-N-(2-(4-(((((3-hydroxycyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide

CAS 23074-07-9C₂₃H₂₈ClN₃O₆S

4'-Hydroxyglibenclamide chemical structure, C23H28ClN3O6S, CAS 23155-04-6

4'-Hydroxyglibenclamide

CAS 23155-04-6C₂₃H₂₈ClN₃O₆S

Suguan chemical structure, C33H43ClN8O5S, CAS 52337-30-1

CAS 52337-30-1C₃₃H₄₃ClN₈O₅S

Sodium 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulphonyl)phenyl)ethyl)-2-methoxybenzamidate chemical structure, C23H27ClN3NaO5S, CAS 20271-40-3

Sodium 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulphonyl)phenyl)ethyl)-2-methoxybenzamidate

CAS 20271-40-3C₂₃H₂₇ClN₃NaO₅S

5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-hydroxybenzamide chemical structure, C22H26ClN3O5S, CAS 57334-90-4

5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-hydroxybenzamide

CAS 57334-90-4C₂₂H₂₆ClN₃O₅S

5-Chloro-2-methoxy-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]benzamide chemical structure, C23H28ClN3O5S, CAS 1189985-02-1

5-Chloro-2-methoxy-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]benzamide

CAS 1189985-02-1C₂₃H₂₈ClN₃O₅S

rac cis-3-Hydroxy Glyburide-d3,13C chemical structure, C23H28ClN3O6S, CAS 1217848-91-3

rac cis-3-Hydroxy Glyburide-d3,13C

CAS 1217848-91-3C₂₃H₂₈ClN₃O₆S

rac trans-4-Hydroxy Glyburide-13C,d3 chemical structure, C23H28ClN3O6S, CAS 1217639-30-9

rac trans-4-Hydroxy Glyburide-13C,d3

CAS 1217639-30-9C₂₃H₂₈ClN₃O₆S

Sodium 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamidate chemical structure, C23H28ClN3NaO5S, CAS 16931-15-0

Sodium 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamidate

CAS 16931-15-0C₂₃H₂₈ClN₃NaO₅S

Rel-5-chloro-N-[2-[4-[[[[[(1R,3R)-3-hydroxycyclohexyl]amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide chemical structure, C23H28ClN3O6S, CAS 586414-84-8

Rel-5-chloro-N-[2-[4-[[[[[(1R,3R)-3-hydroxycyclohexyl]amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide

CAS 586414-84-8C₂₃H₂₈ClN₃O₆S

cis-3-Hydroxyglyburide chemical structure, C23H28ClN3O6S, CAS 23074-02-4

cis-3-Hydroxyglyburide

CAS 23074-02-4C₂₃H₂₈ClN₃O₆S

rac trans-3-Hydroxy Glyburide chemical structure, C23H28ClN3O6S

rac trans-3-Hydroxy Glyburide

C₂₃H₂₈ClN₃O₆S

Hydroxy glyburide chemical structure, C23H28ClN3O6S, CAS 204838-24-4

Hydroxy glyburide

CAS 204838-24-4C₂₃H₂₈ClN₃O₆S

Glyburide-D3 chemical structure, C23H28ClN3O5S, CAS 1219803-02-7

CAS 1219803-02-7C₂₃H₂₈ClN₃O₅S

Glyburide impurity E chemical structure, C23H27Cl2N3O5S, CAS 57334-89-1

Glyburide impurity E

CAS 57334-89-1C₂₃H₂₇Cl₂N₃O₅S

rac trans-2-Hydroxy Glyburide chemical structure, C23H28ClN3O6S, CAS 586414-93-9

rac trans-2-Hydroxy Glyburide

CAS 586414-93-9C₂₃H₂₈ClN₃O₆S

Glyburide (potassium salt) chemical structure, C23H28ClKN3O5S, CAS 52169-36-5

Glyburide (potassium salt)

CAS 52169-36-5C₂₃H₂₈ClKN₃O₅S

Glybenclamide potassium salt chemical structure, C23H28ClKN3O5S+

Glybenclamide potassium salt

C₂₃H₂₈ClKN₃O₅S+

Glibenclamide-potassium salt chemical structure, C23H27ClKN3O5S

Glibenclamide-potassium salt

C₂₃H₂₇ClKN₃O₅S

N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-3-fluorobenzamide chemical structure, C22H26FN3O4S, CAS 1607-58-5

N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-3-fluorobenzamide

CAS 1607-58-5C₂₂H₂₆FN₃O₄S