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Murcko scaffold

Ring system with 5 rings and 31 atoms

21 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
31
Chemicals
21
With full pages
3
Scaffold SMILES

O=c1[nH]c(=O)c2c(nc(NN=Cc3ccccc3)n2Cc2cccc3ccccc23)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=O)c2c(nc(NN=Cc3ccccc3)n2Cc2cccc3ccccc23)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

4-Methylbenzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C26H24N6O2, CAS 478252-81-2
4-Methylbenzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-81-2C26H24N6O2
Benzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C25H22N6O2, CAS 478252-75-4
Benzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-75-4C25H22N6O2
2-Chlorobenzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C25H21ClN6O2, CAS 478252-76-5
2-Chlorobenzaldehyde (1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-76-5C25H21ClN6O2
8-{(2E)-2-[1-(4-Methoxyphenyl)ethylidene]hydrazino}-1,3-dimethyl-7-(1-naphthylmethyl)-3,7-dihydro-1H-purine-2,6-dione chemical structure, C27H26N6O3, CAS 478252-82-3
8-{(2E)-2-[1-(4-Methoxyphenyl)ethylidene]hydrazino}-1,3-dimethyl-7-(1-naphthylmethyl)-3,7-dihydro-1H-purine-2,6-dione
CAS 478252-82-3C27H26N6O3
4-Bromobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C24H19BrN6O2, CAS 478252-68-5
4-Bromobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-68-5C24H19BrN6O2
4-Methoxybenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C25H22N6O3, CAS 478252-57-2
4-Methoxybenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-57-2C25H22N6O3
4-Chlorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C24H19ClN6O2, CAS 478252-67-4
4-Chlorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-67-4C24H19ClN6O2
Benzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C24H20N6O2, CAS 478252-56-1
Benzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-56-1C24H20N6O2
3-Methyl-7-(1-naphthylmethyl)-8-((2E)-2-(1-(4-nitrophenyl)ethylidene)hydrazino)-3,7-dihydro-1H-purine-2,6-dione chemical structure, C25H21N7O4, CAS 478252-66-3
3-Methyl-7-(1-naphthylmethyl)-8-((2E)-2-(1-(4-nitrophenyl)ethylidene)hydrazino)-3,7-dihydro-1H-purine-2,6-dione
CAS 478252-66-3C25H21N7O4
4-Methylbenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C25H22N6O2, CAS 478252-63-0
4-Methylbenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-63-0C25H22N6O2
2-Chlorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C24H19ClN6O2, CAS 478252-69-6
2-Chlorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-69-6C24H19ClN6O2
4-Nitrobenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C24H19N7O4, CAS 478252-64-1
4-Nitrobenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-64-1C24H19N7O4
3-Methyl-7-(1-naphthylmethyl)-8-[(2E)-2-(1-phenylethylidene)hydrazino]-3,7-dihydro-1H-purine-2,6-dione chemical structure, C25H22N6O2, CAS 478252-60-7
3-Methyl-7-(1-naphthylmethyl)-8-[(2E)-2-(1-phenylethylidene)hydrazino]-3,7-dihydro-1H-purine-2,6-dione
CAS 478252-60-7C25H22N6O2
3-Hydroxybenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C24H20N6O3, CAS 478252-74-3
3-Hydroxybenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-74-3C24H20N6O3
3-Nitrobenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C25H21N7O4, CAS 478252-80-1
3-Nitrobenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-80-1C25H21N7O4
4-Nitrobenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C25H21N7O4, CAS 478252-79-8
4-Nitrobenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-79-8C25H21N7O4
3-Nitrobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C24H19N7O4, CAS 478252-65-2
3-Nitrobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-65-2C24H19N7O4
4-Fluorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone chemical structure, C24H19FN6O2, CAS 478252-70-9
4-Fluorobenzaldehyde (3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)hydrazone
CAS 478252-70-9C24H19FN6O2
4-Hydroxybenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C24H20N6O3, CAS 478252-73-2
4-Hydroxybenzaldehyde [3-methyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-73-2C24H20N6O3
5-Bromo-2-hydroxybenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C25H21BrN6O3, CAS 478252-78-7
5-Bromo-2-hydroxybenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-78-7C25H21BrN6O3
2-Hydroxybenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone chemical structure, C25H22N6O3, CAS 478252-77-6
2-Hydroxybenzaldehyde [1,3-dimethyl-7-(1-naphthylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]hydrazone
CAS 478252-77-6C25H22N6O3