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Murcko scaffold

N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[(phenylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide scaffold

29 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
29
With full pages
3
Scaffold SMILES

O=C(Nc1sc2c(c1C(=O)NC1CCS(=O)(=O)C1)CCCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[(phenylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide page
Murcko scaffold O=C(Nc1sc2c(c1C(=O)NC1CCS(=O)(=O)C1)CCCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

2-{[(4-Chlorophenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H21ClN2O4S2, CAS 519012-44-3
2-{[(4-Chlorophenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-44-3C20H21ClN2O4S2
N-(1,1-Dioxothiolan-3-yl)-2-[(2-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H21N3O6S2, CAS 519034-54-9
N-(1,1-Dioxothiolan-3-yl)-2-[(2-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519034-54-9C20H21N3O6S2
2-[(4-tert-Butylbenzoyl)amino]-N-(1,1-dioxothiolan-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H30N2O4S2, CAS 519012-48-7
2-[(4-tert-Butylbenzoyl)amino]-N-(1,1-dioxothiolan-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-48-7C24H30N2O4S2
N-(1,1-Dioxidotetrahydro-3-thienyl)-2-[(2-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O5S2, CAS 519012-42-1
N-(1,1-Dioxidotetrahydro-3-thienyl)-2-[(2-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-42-1C21H24N2O5S2
2-{[(4-Bromophenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H21BrN2O4S2, CAS 519012-43-2
2-{[(4-Bromophenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-43-2C20H21BrN2O4S2
2-{[(3,4-Dimethoxyphenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H26N2O6S2, CAS 519012-49-8
2-{[(3,4-Dimethoxyphenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-49-8C22H26N2O6S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(3,4,5-trimethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H28N2O7S2, CAS 618079-00-8
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(3,4,5-trimethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618079-00-8C23H28N2O7S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-fluorophenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H21FN2O4S2, CAS 519012-45-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-fluorophenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 519012-45-4C20H21FN2O4S2
2-[(3,5-Dichloro-4-methoxybenzoyl)amino]-N-(1,1-dioxothiolan-3-yl)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H24Cl2N2O5S2, CAS 824420-34-0
2-[(3,5-Dichloro-4-methoxybenzoyl)amino]-N-(1,1-dioxothiolan-3-yl)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 824420-34-0C22H24Cl2N2O5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[(phenylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H22N2O4S2, CAS 618078-47-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-[(phenylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618078-47-0C20H22N2O4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-methoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O5S2, CAS 618078-79-8
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-methoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618078-79-8C21H24N2O5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O4S2, CAS 618079-03-1
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618079-03-1C21H24N2O4S2
N-(1,1-Dioxidotetrahydro-3-thienyl)-2-[(3-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O5S2, CAS 618079-06-4
N-(1,1-Dioxidotetrahydro-3-thienyl)-2-[(3-methoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618079-06-4C21H24N2O5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(3-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O4S2, CAS 618078-51-6
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(3-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618078-51-6C21H24N2O4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(2-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24N2O4S2, CAS 608121-60-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(2-methylphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 608121-60-4C21H24N2O4S2
2-[(2,4-Dichlorobenzoyl)amino]-N-(1,1-dioxidotetrahydro-3-thienyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H20Cl2N2O4S2, CAS 618078-91-4
2-[(2,4-Dichlorobenzoyl)amino]-N-(1,1-dioxidotetrahydro-3-thienyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618078-91-4C20H20Cl2N2O4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-({[4-(pentyloxy)phenyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H32N2O5S2, CAS 797796-77-1
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-({[4-(pentyloxy)phenyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 797796-77-1C25H32N2O5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-ethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H26N2O5S2, CAS 618079-24-6
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(4-ethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618079-24-6C22H26N2O5S2
2-[(2-Bromobenzoyl)amino]-N-(1,1-dioxidotetrahydro-3-thienyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H21BrN2O4S2, CAS 618079-15-5
2-[(2-Bromobenzoyl)amino]-N-(1,1-dioxidotetrahydro-3-thienyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618079-15-5C20H21BrN2O4S2
2-(2-Chlorobenzamido)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C20H21ClN2O4S2, CAS 618078-76-5
2-(2-Chlorobenzamido)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 618078-76-5C20H21ClN2O4S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(2-ethoxyphenyl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H28N2O5S2, CAS 862488-72-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-{[(2-ethoxyphenyl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 862488-72-0C23H28N2O5S2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-({[4-(propan-2-yloxy)phenyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H28N2O5S2, CAS 618078-85-6
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-({[4-(propan-2-yloxy)phenyl]carbonyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 618078-85-6C23H28N2O5S2
2-{[(4-Butoxyphenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H30N2O5S2, CAS 797799-03-2
2-{[(4-Butoxyphenyl)carbonyl]amino}-N-(1,1-dioxidotetrahydrothiophen-3-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 797799-03-2C24H30N2O5S2
6-tert-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-{[(3-methoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H32N2O5S2, CAS 845630-07-1
6-tert-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-{[(3-methoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 845630-07-1C25H32N2O5S2