Murcko scaffold
Ring system with 5 rings and 27 atoms
23 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 27
- Chemicals
- 23
- With full pages
- 6
Scaffold SMILES
O=c1c2ccccc2n2c(-c3ccccc3)nnc2n1Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 23 of 23 chemicals
![N-[4-[4-[(2-Chlorophenyl)methyl]-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]phenyl]acetamide chemical structure, C24H18ClN5O2, CAS 866896-51-7](/s/PZGMWUHAXRHCQD-UHFFFAOYSA-N.svg)
N-[4-[4-[(2-Chlorophenyl)methyl]-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]phenyl]acetamide
CAS 866896-51-7C24H18ClN5O2
![4-Benzyl-1-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C22H15ClN4O, CAS 866896-44-8](/s/AJGGHJDEMDXYEJ-UHFFFAOYSA-N.svg)
4-Benzyl-1-(3-chlorophenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 866896-44-8C22H15ClN4O
![4-Benzyl-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H15F3N4O, CAS 866896-43-7](/s/WGOQLNHZMKWAIH-UHFFFAOYSA-N.svg)
4-Benzyl-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 866896-43-7C23H15F3N4O
![4-[(4-Methylphenyl)methyl]-1-phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H18N4O, CAS 902890-17-9](/s/WCUBQTHNJVBJIH-UHFFFAOYSA-N.svg)
4-[(4-Methylphenyl)methyl]-1-phenyl-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902890-17-9C23H18N4O
![4-(4-Methoxybenzyl)-1-(4-methylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C24H20N4O2, CAS 902891-86-5](/s/GTSWVMDGLMSLLP-UHFFFAOYSA-N.svg)
4-(4-Methoxybenzyl)-1-(4-methylphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 902891-86-5C24H20N4O2
![4-Benzyl-1-(4-bromophenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C22H15BrN4O, CAS 866896-41-5](/s/IZNANOLPRRAIMQ-UHFFFAOYSA-N.svg)
4-Benzyl-1-(4-bromophenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 866896-41-5C22H15BrN4O
![4-(2-Chlorobenzyl)-1-(2,4,5-trimethoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C25H21ClN4O4, CAS 866896-48-2](/s/WLIIRZAYOSQILK-UHFFFAOYSA-N.svg)
4-(2-Chlorobenzyl)-1-(2,4,5-trimethoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 866896-48-2C25H21ClN4O4
![4-[(2-Chlorophenyl)methyl]-1-(2,4-dimethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H19ClN4O3, CAS 866896-49-3](/s/NAHFHCMOTPHZSB-UHFFFAOYSA-N.svg)
4-[(2-Chlorophenyl)methyl]-1-(2,4-dimethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 866896-49-3C24H19ClN4O3
![1-(4-Bromophenyl)-4-[(4-methoxyphenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H17BrN4O2, CAS 866896-52-8](/s/JMHPZPRTSWYOKW-UHFFFAOYSA-N.svg)
1-(4-Bromophenyl)-4-[(4-methoxyphenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 866896-52-8C23H17BrN4O2
![4-Benzyl-1-(4-chlorophenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C22H15ClN4O, CAS 902884-71-3](/s/XKQFEWBBRJFMHF-UHFFFAOYSA-N.svg)
4-Benzyl-1-(4-chlorophenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902884-71-3C22H15ClN4O
![4-Benzyl-1-(3-methylphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H18N4O, CAS 902885-03-4](/s/UUCFGNJHSBFAEZ-UHFFFAOYSA-N.svg)
4-Benzyl-1-(3-methylphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902885-03-4C23H18N4O
![4-[(4-Methylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H17F3N4O, CAS 902890-37-3](/s/SBYQJTSSVYNYLB-UHFFFAOYSA-N.svg)
4-[(4-Methylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902890-37-3C24H17F3N4O
![1-(2,3-Dimethoxyphenyl)-4-[(4-fluorophenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H19FN4O3, CAS 902890-65-7](/s/JNRLNGRJJFCOPU-UHFFFAOYSA-N.svg)
1-(2,3-Dimethoxyphenyl)-4-[(4-fluorophenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902890-65-7C24H19FN4O3
![4-[(4-Fluorophenyl)methyl]-1-(2-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H17FN4O2, CAS 902890-77-1](/s/MXARFOOHTAQWMW-UHFFFAOYSA-N.svg)
4-[(4-Fluorophenyl)methyl]-1-(2-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902890-77-1C23H17FN4O2
![1-(3,4-Dimethoxyphenyl)-4-[(4-fluorophenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H19FN4O3, CAS 902890-97-5](/s/PXUBGKVTMZQMNJ-UHFFFAOYSA-N.svg)
1-(3,4-Dimethoxyphenyl)-4-[(4-fluorophenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902890-97-5C24H19FN4O3
![4-[(4-Fluorophenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H14F4N4O, CAS 902891-15-0](/s/DNOJHYCOWFIPTJ-UHFFFAOYSA-N.svg)
4-[(4-Fluorophenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902891-15-0C23H14F4N4O
![4-[(4-Fluorophenyl)methyl]-1-(3-methylphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C23H17FN4O, CAS 902891-21-8](/s/CLSMRWPLMQMSLH-UHFFFAOYSA-N.svg)
4-[(4-Fluorophenyl)methyl]-1-(3-methylphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902891-21-8C23H17FN4O
![1-(3-Methoxyphenyl)-4-[(4-methoxyphenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H20N4O3, CAS 902891-78-5](/s/DKNZVTYRGMBJTC-UHFFFAOYSA-N.svg)
1-(3-Methoxyphenyl)-4-[(4-methoxyphenyl)methyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902891-78-5C24H20N4O3
![4-(2-Chlorobenzyl)-1-(2-hydroxy-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C23H17ClN4O3, CAS 902891-37-6](/s/MUHNHVCFKYIXPU-UHFFFAOYSA-N.svg)
4-(2-Chlorobenzyl)-1-(2-hydroxy-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 902891-37-6C23H17ClN4O3
![4-Benzyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one chemical structure, C24H20N4O4, CAS 902884-95-1](/s/ZOSGKRGWBURQHX-UHFFFAOYSA-N.svg)
4-Benzyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
CAS 902884-95-1C24H20N4O4
![4-(4-Fluorobenzyl)-1-(4-hydroxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C22H15FN4O2, CAS 902890-87-3](/s/KSBKRJIAVLQCKM-UHFFFAOYSA-N.svg)
4-(4-Fluorobenzyl)-1-(4-hydroxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 902890-87-3C22H15FN4O2
![1-(4-Hydroxyphenyl)-4-(4-methoxybenzyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one chemical structure, C23H18N4O3, CAS 902891-72-9](/s/PRVDLSCPKNSHDC-UHFFFAOYSA-N.svg)
1-(4-Hydroxyphenyl)-4-(4-methoxybenzyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
CAS 902891-72-9C23H18N4O3
![3-[4-(2-Chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxybenzoic Acid chemical structure, C23H15ClN4O4, CAS 2222280-83-1](/s/AEJITBHMBLVYPB-UHFFFAOYSA-N.svg)
3-[4-(2-Chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxybenzoic Acid
CAS 2222280-83-1C23H15ClN4O4