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Murcko scaffold

2-(Pyridin-2-yl)pyrimidin-4(3H)-one scaffold

77 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
77
With full pages
12
Scaffold SMILES

O=c1ccnc(-c2ccccn2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Pyridin-2-yl)pyrimidin-4(3H)-one page
Murcko scaffold O=c1ccnc(-c2ccccn2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

Ethyl 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylate chemical structure, C12H11N3O3, CAS 60060-10-8
Ethyl 4-hydroxy-2-(2-pyridinyl)-5-pyrimidinecarboxylate
CAS 60060-10-8C12H11N3O3
Ethyl 1,6-dihydro-6-oxo-2-[5-(trifluoromethyl)-2-pyridinyl]-5-pyrimidinecarboxylate chemical structure, C13H10F3N3O3, CAS 266679-43-0
Ethyl 1,6-dihydro-6-oxo-2-[5-(trifluoromethyl)-2-pyridinyl]-5-pyrimidinecarboxylate
CAS 266679-43-0C13H10F3N3O3
5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-ol chemical structure, C10H9N3O2, CAS 321432-75-1
5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-ol
CAS 321432-75-1C10H9N3O2
2-(Pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C9H7N3O, CAS 64264-15-9
2-(Pyridin-2-yl)pyrimidin-4(3H)-one
CAS 64264-15-9C9H7N3O
4-Hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid chemical structure, C10H7N3O3, CAS 56406-45-2
4-Hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid
CAS 56406-45-2C10H7N3O3
6-Hydroxy-2-(pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C9H7N3O2, CAS 10198-74-0
6-Hydroxy-2-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS 10198-74-0C9H7N3O2
5-Bromo-2-(pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C9H6BrN3O, CAS 1044767-93-2
5-Bromo-2-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS 1044767-93-2C9H6BrN3O
5-Methyl-2-(pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C10H9N3O, CAS 1044768-25-3
5-Methyl-2-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS 1044768-25-3C10H9N3O
5-Fluoro-2-(pyridin-2-yl)pyrimidin-4-ol chemical structure, C9H6FN3O, CAS 1240596-22-8
5-Fluoro-2-(pyridin-2-yl)pyrimidin-4-ol
CAS 1240596-22-8C9H6FN3O
2-(3-Chloro-pyridin-2-yl)-pyrimidin-4-ol chemical structure, C9H6ClN3O, CAS 1089330-88-0
2-(3-Chloro-pyridin-2-yl)-pyrimidin-4-ol
CAS 1089330-88-0C9H6ClN3O
2-(6-Chloro-pyridin-2-yl)-pyrimidin-4-ol chemical structure, C9H6ClN3O, CAS 1011231-28-9
2-(6-Chloro-pyridin-2-yl)-pyrimidin-4-ol
CAS 1011231-28-9C9H6ClN3O
2-(6-Methylpyridin-2-yl)pyrimidine-4,6-diol chemical structure, C10H9N3O2, CAS 1001915-36-1
2-(6-Methylpyridin-2-yl)pyrimidine-4,6-diol
CAS 1001915-36-1C10H9N3O2
6-Hydroxy-5-methyl-2-(pyridin-2-yl)-3,4-dihydropyrimidin-4-one chemical structure, C10H9N3O2, CAS 10198-75-1
6-Hydroxy-5-methyl-2-(pyridin-2-yl)-3,4-dihydropyrimidin-4-one
CAS 10198-75-1C10H9N3O2
5-Iodo-2-(pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C9H6IN3O, CAS 1522747-55-2
5-Iodo-2-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS 1522747-55-2C9H6IN3O
5-Isopropoxy-2-pyridin-2-yl-3H-pyrimidin-4-one chemical structure, C12H13N3O2, CAS 1269626-42-7
5-Isopropoxy-2-pyridin-2-yl-3H-pyrimidin-4-one
CAS 1269626-42-7C12H13N3O2
5-Amino-2-(pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C9H8N4O, CAS 1343461-00-6
5-Amino-2-(pyridin-2-yl)pyrimidin-4(3H)-one
CAS 1343461-00-6C9H8N4O
6-Oxo-2-(pyridin-2-yl)-1,6-dihydropyrimidine-5-carbonitrile chemical structure, C10H6N4O, CAS 1368926-32-2
6-Oxo-2-(pyridin-2-yl)-1,6-dihydropyrimidine-5-carbonitrile
CAS 1368926-32-2C10H6N4O
[4-Oxo-2-(pyridin-2-yl)-3H-pyrimidin-5-yl]acetic acid chemical structure, C11H9N3O3, CAS 1780103-45-8
[4-Oxo-2-(pyridin-2-yl)-3H-pyrimidin-5-yl]acetic acid
CAS 1780103-45-8C11H9N3O3
2-(Pyridin-2-yl)-5-((trimethylsilyl)ethynyl)pyrimidin-4-ol chemical structure, C14H15N3OSi, CAS 1428527-76-7
2-(Pyridin-2-yl)-5-((trimethylsilyl)ethynyl)pyrimidin-4-ol
CAS 1428527-76-7C14H15N3OSi
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidin-4(3H)-one chemical structure, C10H4ClF4N3O, CAS 1823188-43-7
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidin-4(3H)-one
CAS 1823188-43-7C10H4ClF4N3O
5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-4(3H)-one chemical structure, C10H4F5N3O, CAS 1823182-31-5
5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-4(3H)-one
CAS 1823182-31-5C10H4F5N3O
2-(5-Bromopyridin-2-yl)pyrimidin-4-ol chemical structure, C9H6BrN3O, CAS 1566901-84-5
2-(5-Bromopyridin-2-yl)pyrimidin-4-ol
CAS 1566901-84-5C9H6BrN3O
2-(6-(Trifluoromethyl)pyridin-2-yl)pyrimidine-4,6-diol chemical structure, C10H6F3N3O2, CAS 1644386-44-6
2-(6-(Trifluoromethyl)pyridin-2-yl)pyrimidine-4,6-diol
CAS 1644386-44-6C10H6F3N3O2
2-(3-Fluoropyridin-2-yl)-5-isopropylpyrimidin-4-ol chemical structure, C12H12FN3O, CAS 2732991-11-4
2-(3-Fluoropyridin-2-yl)-5-isopropylpyrimidin-4-ol
CAS 2732991-11-4C12H12FN3O