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Murcko scaffold

Ring system with 4 rings and 27 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
14
With full pages
1
Scaffold SMILES

c1ccc(N2CCN(CCCN3CCN(c4ccccc4)CC3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(CCCN3CCN(c4ccccc4)CC3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

Ro 8-2580 chemical structure, C25H36N4O3, CAS 34244-69-4
Ro 8-2580
CAS 34244-69-4C25H36N4O3
1-(4-Chlorophenyl)-4-[3-[4-(2-methylphenyl)piperazin-1-yl]propyl]piperazine chemical structure, C24H33ClN4, CAS 6320-27-0
1-(4-Chlorophenyl)-4-[3-[4-(2-methylphenyl)piperazin-1-yl]propyl]piperazine
CAS 6320-27-0C24H33ClN4
1-(3-Chlorophenyl)-4-[3-[4-(3-methylphenyl)piperazin-1-yl]propyl]piperazine chemical structure, C24H33ClN4, CAS 6320-28-1
1-(3-Chlorophenyl)-4-[3-[4-(3-methylphenyl)piperazin-1-yl]propyl]piperazine
CAS 6320-28-1C24H33ClN4
1-(4-Chlorophenyl)-4-{3-[4-(3-methylphenyl)piperazin-1-yl]propyl}piperazine chemical structure, C24H33ClN4, CAS 6320-29-2
1-(4-Chlorophenyl)-4-{3-[4-(3-methylphenyl)piperazin-1-yl]propyl}piperazine
CAS 6320-29-2C24H33ClN4
1-(2-Methylphenyl)-4-[3-(4-phenylpiperazin-1-yl)propyl]piperazine chemical structure, C24H34N4, CAS 6323-13-3
1-(2-Methylphenyl)-4-[3-(4-phenylpiperazin-1-yl)propyl]piperazine
CAS 6323-13-3C24H34N4
1-(2-Chlorophenyl)-4-[3-(4-phenylpiperazin-1-yl)propyl]piperazine chemical structure, C23H31ClN4, CAS 6323-12-2
1-(2-Chlorophenyl)-4-[3-(4-phenylpiperazin-1-yl)propyl]piperazine
CAS 6323-12-2C23H31ClN4
1,1'-Propane-1,3-diylbis[4-(3-methylphenyl)piperazine] chemical structure, C25H36N4, CAS 6323-11-1
1,1'-Propane-1,3-diylbis[4-(3-methylphenyl)piperazine]
CAS 6323-11-1C25H36N4
1-(2-Chlorophenyl)-4-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}piperazine chemical structure, C23H30Cl2N4, CAS 6323-10-0
1-(2-Chlorophenyl)-4-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}piperazine
CAS 6323-10-0C23H30Cl2N4
1,3-Bis-(4-(3-chlorophenyl)piperazin-1-yl)propane chemical structure, C23H30Cl2N4, CAS 6323-09-7
1,3-Bis-(4-(3-chlorophenyl)piperazin-1-yl)propane
CAS 6323-09-7C23H30Cl2N4
1-Piperazineethanol, 4-(3-(trifluoromethyl)phenyl)-alpha-((4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, dihydrochloride chemical structure, C25H32Cl2F6N4O, CAS 67931-87-7
1-Piperazineethanol, 4-(3-(trifluoromethyl)phenyl)-alpha-((4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, dihydrochloride
CAS 67931-87-7C25H32Cl2F6N4O
1-Piperazineethanol, 4-(3-(trifluoromethyl)phenyl)-alpha-((4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, phosphate (1:2) (salt) chemical structure, C25H36F6N4O9P2, CAS 67931-90-2
1-Piperazineethanol, 4-(3-(trifluoromethyl)phenyl)-alpha-((4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)methyl)-, phosphate (1:2) (salt)
CAS 67931-90-2C25H36F6N4O9P2
LJ 1198 chemical structure, C25H34F8N4O9P2, CAS 67931-99-1
LJ 1198
CAS 67931-99-1C25H34F8N4O9P2
1,3-Bis-[4-(3-chlorophenyl)piperazin-1-yl]propane Dihydrochloride chemical structure, C23H32Cl4N4, CAS 2408971-27-5
1,3-Bis-[4-(3-chlorophenyl)piperazin-1-yl]propane Dihydrochloride
CAS 2408971-27-5C23H32Cl4N4
1,3-Bis[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-ol chemical structure, C25H36N4O3, CAS 2375270-79-2
1,3-Bis[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-ol
CAS 2375270-79-2C25H36N4O3