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Murcko scaffold

3-(1,3-Benzodioxol-5-ylmethylamino)-1-phenylpyrrolidine-2,5-dione scaffold

26 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
26
With full pages
8
Scaffold SMILES

O=C1CC(NCc2ccc3c(c2)OCO3)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(1,3-Benzodioxol-5-ylmethylamino)-1-phenylpyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(NCc2ccc3c(c2)OCO3)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-bromophenyl)pyrrolidine-2,5-dione chemical structure, C18H15BrN2O4, CAS 340982-69-6
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-bromophenyl)pyrrolidine-2,5-dione
CAS 340982-69-6C18H15BrN2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O5, CAS 497925-38-9
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 497925-38-9C21H22N2O5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C18H15ClN2O4, CAS 359851-63-1
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-chlorophenyl)pyrrolidine-2,5-dione
CAS 359851-63-1C18H15ClN2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-phenylpyrrolidine-2,5-dione chemical structure, C18H16N2O4, CAS 339989-48-9
3-(1,3-Benzodioxol-5-ylmethylamino)-1-phenylpyrrolidine-2,5-dione
CAS 339989-48-9C18H16N2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C18H15ClN2O4, CAS 471293-95-5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-chlorophenyl)pyrrolidine-2,5-dione
CAS 471293-95-5C18H15ClN2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-hexoxyphenyl)pyrrolidine-2,5-dione chemical structure, C24H28N2O5, CAS 469890-41-3
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-hexoxyphenyl)pyrrolidine-2,5-dione
CAS 469890-41-3C24H28N2O5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C18H15FN2O4, CAS 5652-89-1
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 5652-89-1C18H15FN2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-bromophenyl)pyrrolidine-2,5-dione chemical structure, C18H15BrN2O4, CAS 340982-67-4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-bromophenyl)pyrrolidine-2,5-dione
CAS 340982-67-4C18H15BrN2O4
Methyl 4-{3-[(1,3-benzodioxol-5-ylmethyl)amino]-2,5-dioxopyrrolidin-1-yl}benzoate chemical structure, C20H18N2O6, CAS 355142-90-4
Methyl 4-{3-[(1,3-benzodioxol-5-ylmethyl)amino]-2,5-dioxopyrrolidin-1-yl}benzoate
CAS 355142-90-4C20H18N2O6
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide chemical structure, C20H17ClN2O5, CAS 499100-35-5
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide
CAS 499100-35-5C20H17ClN2O5
N-(1,3-Benzodioxol-5-ylmethyl)-N-(2,5-dioxo-1-phenylpyrrolidin-3-yl)acetamide chemical structure, C20H18N2O5, CAS 355143-01-0
N-(1,3-Benzodioxol-5-ylmethyl)-N-(2,5-dioxo-1-phenylpyrrolidin-3-yl)acetamide
CAS 355143-01-0C20H18N2O5
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-bromophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide chemical structure, C20H17BrN2O5, CAS 355403-68-8
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-bromophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide
CAS 355403-68-8C20H17BrN2O5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C20H20N2O5, CAS 470695-80-8
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 470695-80-8C20H20N2O5
N-(1,3-Benzodioxol-5-ylmethyl)-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]acetamide chemical structure, C23H24N2O6, CAS 470695-97-7
N-(1,3-Benzodioxol-5-ylmethyl)-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]acetamide
CAS 470695-97-7C23H24N2O6
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide chemical structure, C20H17ClN2O5, CAS 361380-41-8
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(3-chlorophenyl)-2,5-dioxopyrrolidin-3-yl]acetamide
CAS 361380-41-8C20H17ClN2O5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-butoxyphenyl)pyrrolidine-2,5-dione chemical structure, C22H24N2O5, CAS 318245-53-3
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-butoxyphenyl)pyrrolidine-2,5-dione
CAS 318245-53-3C22H24N2O5
1-(1,3-Benzodioxol-5-ylmethyl)-1-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylthiourea chemical structure, C20H18FN3O4S, CAS 355143-17-8
1-(1,3-Benzodioxol-5-ylmethyl)-1-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylthiourea
CAS 355143-17-8C20H18FN3O4S
Ethyl 4-[3-(1,3-benzodioxol-5-ylmethylamino)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C21H20N2O6, CAS 355138-28-2
Ethyl 4-[3-(1,3-benzodioxol-5-ylmethylamino)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 355138-28-2C21H20N2O6
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-iodophenyl)pyrrolidine-2,5-dione chemical structure, C18H15IN2O4, CAS 497925-39-0
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(4-iodophenyl)pyrrolidine-2,5-dione
CAS 497925-39-0C18H15IN2O4
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C19H17ClN2O4, CAS 355138-25-9
3-(1,3-Benzodioxol-5-ylmethylamino)-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione
CAS 355138-25-9C19H17ClN2O4
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-bromophenyl)-2,5-dioxopyrrolidin-3-yl]propanamide chemical structure, C21H19BrN2O5, CAS 473266-79-4
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-bromophenyl)-2,5-dioxopyrrolidin-3-yl]propanamide
CAS 473266-79-4C21H19BrN2O5
3-(1,3-Benzodioxol-5-ylmethylamino)-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5-dione chemical structure, C19H15F3N2O5, CAS 473443-72-0
3-(1,3-Benzodioxol-5-ylmethylamino)-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5-dione
CAS 473443-72-0C19H15F3N2O5
Butyl 4-{3-[(1,3-benzodioxol-5-ylmethyl)amino]-2,5-dioxopyrrolidin-1-yl}benzoate chemical structure, C23H24N2O6, CAS 367928-97-0
Butyl 4-{3-[(1,3-benzodioxol-5-ylmethyl)amino]-2,5-dioxopyrrolidin-1-yl}benzoate
CAS 367928-97-0C23H24N2O6
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]acetamide chemical structure, C22H22N2O6, CAS 339988-97-5
N-(1,3-Benzodioxol-5-ylmethyl)-N-[1-(4-ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]acetamide
CAS 339988-97-5C22H22N2O6