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Murcko scaffold

1-Benzoyl-4-[(2-naphthyloxy)acetyl]piperazine scaffold

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
13
With full pages
4
Scaffold SMILES

O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-[(2-naphthyloxy)acetyl]piperazine page
Murcko scaffold O=C(COc1ccc2ccccc2c1)N1CCN(C(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

1-[4-(3,5-Dimethoxy-benzoyl)-piperazin-1-yl]-2-(naphthalen-2-yloxy)-ethanone chemical structure, C25H26N2O5, CAS 333756-82-4
1-[4-(3,5-Dimethoxy-benzoyl)-piperazin-1-yl]-2-(naphthalen-2-yloxy)-ethanone
CAS 333756-82-4C25H26N2O5
1-[4-(2-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C23H21FN2O3, CAS 423739-74-6
1-[4-(2-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 423739-74-6C23H21FN2O3
1-[4-(3-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C23H21FN2O3, CAS 423746-32-1
1-[4-(3-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 423746-32-1C23H21FN2O3
1-[4-(2,6-Dimethoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C25H26N2O5, CAS 423736-70-3
1-[4-(2,6-Dimethoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 423736-70-3C25H26N2O5
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C23H21FN2O3, CAS 423734-29-6
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 423734-29-6C23H21FN2O3
1-Benzoyl-4-[(2-naphthyloxy)acetyl]piperazine chemical structure, C23H22N2O3, CAS 423738-43-6
1-Benzoyl-4-[(2-naphthyloxy)acetyl]piperazine
CAS 423738-43-6C23H22N2O3
1-[4-(3-Methoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C24H24N2O4, CAS 423734-32-1
1-[4-(3-Methoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 423734-32-1C24H24N2O4
1-(2,3-Dimethoxybenzoyl)-4-[(2-naphthyloxy)acetyl]piperazine chemical structure, C25H26N2O5, CAS 333756-12-0
1-(2,3-Dimethoxybenzoyl)-4-[(2-naphthyloxy)acetyl]piperazine
CAS 333756-12-0C25H26N2O5
2-Naphthalen-2-yloxy-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone chemical structure, C23H21N3O5, CAS 333756-27-7
2-Naphthalen-2-yloxy-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone
CAS 333756-27-7C23H21N3O5
1-{4-[(4-Methoxyphenyl)carbonyl]piperazin-1-yl}-2-(naphthalen-2-yloxy)ethanone chemical structure, C24H24N2O4, CAS 333756-40-4
1-{4-[(4-Methoxyphenyl)carbonyl]piperazin-1-yl}-2-(naphthalen-2-yloxy)ethanone
CAS 333756-40-4C24H24N2O4
1-[(2-Naphthyloxy)acetyl]-4-(3,4,5-trimethoxybenzoyl)piperazine chemical structure, C26H28N2O6, CAS 333757-68-9
1-[(2-Naphthyloxy)acetyl]-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS 333757-68-9C26H28N2O6
1-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C23H21ClN2O3, CAS 518996-43-5
1-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 518996-43-5C23H21ClN2O3
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone chemical structure, C25H26N2O5, CAS 792929-44-3
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-naphthalen-2-yloxyethanone
CAS 792929-44-3C25H26N2O5