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Murcko scaffold

Ring system with 4 rings and 28 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
8
With full pages
2
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccc(N2CCOCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccc(N2CCOCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

2-[[5-(4-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-chloro-4-morpholin-4-ylphenyl)acetamide chemical structure, C22H25ClN6O2S, CAS 500266-03-5
2-[[5-(4-Aminophenyl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-chloro-4-morpholin-4-ylphenyl)acetamide
CAS 500266-03-5C22H25ClN6O2S
N-(3-Chloro-4-morpholin-4-ylphenyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C21H22ClN5O2S, CAS 692773-94-7
N-(3-Chloro-4-morpholin-4-ylphenyl)-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
CAS 692773-94-7C21H22ClN5O2S
2-[[4-Amino-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C21H24N6O3S, CAS 554426-93-6
2-[[4-Amino-5-(2-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 554426-93-6C21H24N6O3S
2-[(4-Ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C22H25N5O2S, CAS 558458-65-4
2-[(4-Ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 558458-65-4C22H25N5O2S
2-[[5-(2-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C21H22FN5O2S, CAS 878425-34-4
2-[[5-(2-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 878425-34-4C21H22FN5O2S
2-[[4-Methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C22H25N5O2S, CAS 878426-01-8
2-[[4-Methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 878426-01-8C22H25N5O2S
2-[[5-(4-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C21H22FN5O2S, CAS 556831-91-5
2-[[5-(4-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 556831-91-5C21H22FN5O2S
2-[[5-(3-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide chemical structure, C21H22FN5O2S, CAS 879056-73-2
2-[[5-(3-Fluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-morpholin-4-ylphenyl)acetamide
CAS 879056-73-2C21H22FN5O2S