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Murcko scaffold

Ring system with 3 rings and 24 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
25
With full pages
6
Scaffold SMILES

O=C(CCn1cccn1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCn1cccn1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

3-(3,5-Dimethylpyrazol-1-yl)-1-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]propan-1-one chemical structure, C21H30N4O3S, CAS 890606-29-8
3-(3,5-Dimethylpyrazol-1-yl)-1-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]propan-1-one
CAS 890606-29-8C21H30N4O3S
3-(4-Chloro-3,5-dimethylpyrazolyl)-1-{4-[(4-methylphenyl)sulfonyl]piperazinyl} butan-1-one chemical structure, C20H27ClN4O3S, CAS 890596-96-0
3-(4-Chloro-3,5-dimethylpyrazolyl)-1-{4-[(4-methylphenyl)sulfonyl]piperazinyl} butan-1-one
CAS 890596-96-0C20H27ClN4O3S
3-(4-Chloro-3,5-dimethyl-1H-pyrazol-1-yl)-1-[4-(phenylsulfonyl)piperazino]-1-butanone chemical structure, C19H25ClN4O3S, CAS 890596-58-4
3-(4-Chloro-3,5-dimethyl-1H-pyrazol-1-yl)-1-[4-(phenylsulfonyl)piperazino]-1-butanone
CAS 890596-58-4C19H25ClN4O3S
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-((3,4-dimethylphenyl)sulfonyl)piperazin-1-yl)propan-1-one chemical structure, C20H28N4O3S, CAS 890606-47-0
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-((3,4-dimethylphenyl)sulfonyl)piperazin-1-yl)propan-1-one
CAS 890606-47-0C20H28N4O3S
1-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(phenylsulfonyl)piperazine chemical structure, C18H24N4O3S, CAS 890606-41-4
1-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(phenylsulfonyl)piperazine
CAS 890606-41-4C18H24N4O3S
1-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one chemical structure, C18H23ClN4O3S, CAS 890606-53-8
1-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-3-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one
CAS 890606-53-8C18H23ClN4O3S
1-(4-(Phenylsulfonyl)piperazin-1-yl)-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propan-1-one chemical structure, C19H26N4O3S, CAS 890605-84-2
1-(4-(Phenylsulfonyl)piperazin-1-yl)-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propan-1-one
CAS 890605-84-2C19H26N4O3S
1-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propan-1-one chemical structure, C19H25ClN4O3S, CAS 890605-90-0
1-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propan-1-one
CAS 890605-90-0C19H25ClN4O3S
1-[(3,4-Dimethylphenyl)sulfonyl]-4-[2-methyl-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propanoyl]piperazine chemical structure, C22H32N4O3S, CAS 890603-35-7
1-[(3,4-Dimethylphenyl)sulfonyl]-4-[2-methyl-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propanoyl]piperazine
CAS 890603-35-7C22H32N4O3S
2-Methyl-1-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]-3-(3,4,5-trimethylpyrazol-1-yl)propan-1-one chemical structure, C21H30N4O3S, CAS 890603-40-4
2-Methyl-1-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]-3-(3,4,5-trimethylpyrazol-1-yl)propan-1-one
CAS 890603-40-4C21H30N4O3S
1-[(4-Chlorophenyl)sulfonyl]-4-[2-methyl-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propanoyl]piperazine chemical structure, C20H27ClN4O3S, CAS 890603-45-9
1-[(4-Chlorophenyl)sulfonyl]-4-[2-methyl-3-(3,4,5-trimethyl-1H-pyrazol-1-yl)propanoyl]piperazine
CAS 890603-45-9C20H27ClN4O3S
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-tosylpiperazin-1-yl)propan-1-one chemical structure, C19H26N4O3S, CAS 890606-35-6
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-tosylpiperazin-1-yl)propan-1-one
CAS 890606-35-6C19H26N4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(mesitylsulfonyl)piperazine chemical structure, C21H29BrN4O3S, CAS 890596-38-0
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(mesitylsulfonyl)piperazine
CAS 890596-38-0C21H29BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C19H25BrN4O3S, CAS 890596-32-4
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 890596-32-4C19H25BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(phenylsulfonyl)piperazine chemical structure, C18H23BrN4O3S, CAS 890596-35-7
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-(phenylsulfonyl)piperazine
CAS 890596-35-7C18H23BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(3,4-dimethylphenyl)sulfonyl]piperazine chemical structure, C20H27BrN4O3S, CAS 890596-41-5
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(3,4-dimethylphenyl)sulfonyl]piperazine
CAS 890596-41-5C20H27BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(4-chlorophenyl)sulfonyl]piperazine chemical structure, C18H22BrClN4O3S, CAS 890596-29-9
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-4-[(4-chlorophenyl)sulfonyl]piperazine
CAS 890596-29-9C18H22BrClN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C20H27BrN4O3S, CAS 890596-56-2
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 890596-56-2C20H27BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(3,4-dimethylphenyl)sulfonyl]piperazine chemical structure, C21H29BrN4O3S, CAS 890596-54-0
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(3,4-dimethylphenyl)sulfonyl]piperazine
CAS 890596-54-0C21H29BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-(phenylsulfonyl)piperazine chemical structure, C19H25BrN4O3S, CAS 890596-44-8
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-(phenylsulfonyl)piperazine
CAS 890596-44-8C19H25BrN4O3S
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(2,4-dimethylphenyl)sulfonyl]piperazine chemical structure, C21H29BrN4O3S, CAS 890597-46-3
1-[3-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)butanoyl]-4-[(2,4-dimethylphenyl)sulfonyl]piperazine
CAS 890597-46-3C21H29BrN4O3S
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-(phenylsulfonyl)piperazin-1-yl)butan-1-one chemical structure, C19H26N4O3S, CAS 1015845-22-3
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-(phenylsulfonyl)piperazin-1-yl)butan-1-one
CAS 1015845-22-3C19H26N4O3S
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-tosylpiperazin-1-yl)butan-1-one chemical structure, C20H28N4O3S, CAS 1015845-34-7
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-(4-tosylpiperazin-1-yl)butan-1-one
CAS 1015845-34-7C20H28N4O3S
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-[4-(3,4-dimethylbenzenesulfonyl)piperazin-1-yl]butan-1-one chemical structure, C21H30N4O3S, CAS 1017527-34-2
3-(3,5-Dimethyl-1H-pyrazol-1-yl)-1-[4-(3,4-dimethylbenzenesulfonyl)piperazin-1-yl]butan-1-one
CAS 1017527-34-2C21H30N4O3S