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Murcko scaffold

Ring system with 3 rings and 22 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
10
With full pages
8
Scaffold SMILES

O=C(CN1CCN(Cc2ccccc2)CC1)Nc1nncs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCN(Cc2ccccc2)CC1)Nc1nncs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

2-[4-[(2,6-Dichlorophenyl)methyl]piperazin-1-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C16H19Cl2N5OS, CAS 890293-63-7
2-[4-[(2,6-Dichlorophenyl)methyl]piperazin-1-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 890293-63-7C16H19Cl2N5OS
2-[4-[(3-Chlorophenyl)methyl]piperazin-1-yl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C17H22ClN5OS, CAS 891742-12-4
2-[4-[(3-Chlorophenyl)methyl]piperazin-1-yl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 891742-12-4C17H22ClN5OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(4-methylphenyl)methyl]piperazin-1-yl]acetamide chemical structure, C18H25N5OS, CAS 904405-40-9
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(4-methylphenyl)methyl]piperazin-1-yl]acetamide
CAS 904405-40-9C18H25N5OS
2-(4-Benzylpiperazin-1-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C16H21N5OS, CAS 889602-41-9
2-(4-Benzylpiperazin-1-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 889602-41-9C16H21N5OS
2-[4-[(2-Chloro-4-fluorophenyl)methyl]piperazin-1-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C16H19ClFN5OS, CAS 892996-23-5
2-[4-[(2-Chloro-4-fluorophenyl)methyl]piperazin-1-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 892996-23-5C16H19ClFN5OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]acetamide chemical structure, C17H22FN5OS, CAS 890296-79-4
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]acetamide
CAS 890296-79-4C17H22FN5OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]acetamide chemical structure, C18H25N5O2S, CAS 904816-28-0
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]acetamide
CAS 904816-28-0C18H25N5O2S
2-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C17H22ClN5OS, CAS 903700-65-2
2-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide
CAS 903700-65-2C17H22ClN5OS
2-{4-[(4-Fluorophenyl)methyl]piperazinyl}-N-(1,3,4-thiadiazol-2-yl)acetamide chemical structure, C15H18FN5OS, CAS 890296-76-1
2-{4-[(4-Fluorophenyl)methyl]piperazinyl}-N-(1,3,4-thiadiazol-2-yl)acetamide
CAS 890296-76-1C15H18FN5OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-(3-fluorobenzyl)-1-piperazinyl]acetamide chemical structure, C17H22FN5OS, CAS 725225-47-8
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-[4-(3-fluorobenzyl)-1-piperazinyl]acetamide
CAS 725225-47-8C17H22FN5OS