Murcko scaffold
N-(4-Phenyl-1,3-thiazol-2-yl)bicyclo[2.2.1]heptane-3-carboxamide scaffold
15 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 21
- Chemicals
- 15
- With full pages
- 5
Scaffold SMILES
O=C(Nc1nc(-c2ccccc2)cs1)C1CC2CCC1C2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 15 of 15 chemicals
![N-(4-Phenyl-1,3-thiazol-2-yl)bicyclo[2.2.1]heptane-3-carboxamide chemical structure, C17H18N2OS, CAS 464923-23-7](/s/XKHFLVTZNPUADI-UHFFFAOYSA-N.svg)
N-(4-Phenyl-1,3-thiazol-2-yl)bicyclo[2.2.1]heptane-3-carboxamide
CAS 464923-23-7C17H18N2OS
![N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]bicyclo[2.2.1]heptane-2-carboxamide chemical structure, C17H17ClN2OS, CAS 468093-09-6](/s/NWMIBZXECKEBCV-UHFFFAOYSA-N.svg)
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]bicyclo[2.2.1]heptane-2-carboxamide
CAS 468093-09-6C17H17ClN2OS
![3-{[4-(4-Ethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C20H22N2O3S, CAS 473446-39-8](/s/CZLISFNNPUJHCS-UHFFFAOYSA-N.svg)
3-{[4-(4-Ethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 473446-39-8C20H22N2O3S
![3-({[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C20H22N2O3S, CAS 473446-51-4](/s/SBJCNDYDDCGNTH-UHFFFAOYSA-N.svg)
3-({[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 473446-51-4C20H22N2O3S
![3-({[4-(4-Isopropylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C21H24N2O3S, CAS 473446-65-0](/s/ZMSHIFMKDNYFDC-UHFFFAOYSA-N.svg)
3-({[4-(4-Isopropylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 473446-65-0C21H24N2O3S
![3-{[4-(4-Methylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C19H20N2O3S, CAS 345347-85-5](/s/IYUWYFPSPMFUOT-UHFFFAOYSA-N.svg)
3-{[4-(4-Methylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 345347-85-5C19H20N2O3S
![3-{[4-(2,4-Difluorophenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C18H16F2N2O3S, CAS 345288-44-0](/s/FMOYQCTWRYPGEZ-UHFFFAOYSA-N.svg)
3-{[4-(2,4-Difluorophenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 345288-44-0C18H16F2N2O3S
![3-{[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C20H22N2O3S, CAS 6131-53-9](/s/AIPOSJPUOSGZHA-UHFFFAOYSA-N.svg)
3-{[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 6131-53-9C20H22N2O3S
![3-((4-(4-Bromophenyl)thiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C18H17BrN2O3S, CAS 849658-83-9](/s/VCXVSXKWDHGHLX-UHFFFAOYSA-N.svg)
3-((4-(4-Bromophenyl)thiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 849658-83-9C18H17BrN2O3S
![3-{[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C20H22N2O3S, CAS 473446-86-5](/s/ZBWKEBXHQPHRIQ-UHFFFAOYSA-N.svg)
3-{[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 473446-86-5C20H22N2O3S
![3-{[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C18H16Cl2N2O3S, CAS 345288-45-1](/s/SFVLIEZTBJKXKQ-UHFFFAOYSA-N.svg)
3-{[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]carbamoyl}bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 345288-45-1C18H16Cl2N2O3S
![3-({[4-(4-Isopropylphenyl)-5-methyl-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C22H26N2O3S, CAS 494790-46-4](/s/HWHYSSATNZEECJ-UHFFFAOYSA-N.svg)
3-({[4-(4-Isopropylphenyl)-5-methyl-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 494790-46-4C22H26N2O3S
![3-({[4-(4-Isobutylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C22H26N2O3S, CAS 361366-77-0](/s/SYMHCTPDXDKNHO-UHFFFAOYSA-N.svg)
3-({[4-(4-Isobutylphenyl)-1,3-thiazol-2-yl]amino}carbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 361366-77-0C22H26N2O3S
![(1S,2R,3S,4R)-3-[[5-Methyl-4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]carbamoyl]bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C22H26N2O3S, CAS 849658-87-3](/s/HWHYSSATNZEECJ-VSZNYVQBSA-N.svg)
(1S,2R,3S,4R)-3-[[5-Methyl-4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]carbamoyl]bicyclo[2.2.1]heptane-2-carboxylic acid
CAS 849658-87-3C22H26N2O3S
![Rel-(1R,2S,3R,4S)-3-((4-(4-bromophenyl)thiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid chemical structure, C18H17BrN2O3S](/s/VCXVSXKWDHGHLX-DRABBMOASA-N.svg)
Rel-(1R,2S,3R,4S)-3-((4-(4-bromophenyl)thiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid
C18H17BrN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(Nc1c[nH]n(-c2ccccc2)c1=O)C1CC2C=CC1C2](/scaffold/JXAOOKBOUNRZLF-UHFFFAOYSA-N/structure.svg)
