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Murcko scaffold

2-(1,3-Dioxoisoindolin-2-yl)-N-(4-phenylthiazol-2-yl)acetamide scaffold

26 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
26
With full pages
3
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)Nc1nc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1,3-Dioxoisoindolin-2-yl)-N-(4-phenylthiazol-2-yl)acetamide page
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)Nc1nc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide chemical structure, C19H12BrN3O3S, CAS 54890-74-3
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
CAS 54890-74-3C19H12BrN3O3S
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-phenylthiazol-2-yl)acetamide chemical structure, C19H13N3O3S, CAS 54890-71-0
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-phenylthiazol-2-yl)acetamide
CAS 54890-71-0C19H13N3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C20H15N3O3S, CAS 54890-72-1
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 54890-72-1C20H15N3O3S
2-(1,3-Dioxobenzo[c]azolidin-2-yl)-N-(5-methyl-4-phenyl(1,3-thiazol-2-yl))acet amide chemical structure, C20H15N3O3S, CAS 313702-43-1
2-(1,3-Dioxobenzo[c]azolidin-2-yl)-N-(5-methyl-4-phenyl(1,3-thiazol-2-yl))acet amide
CAS 313702-43-1C20H15N3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2E)-5-methyl-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]acetamide chemical structure, C21H17N3O3S, CAS 54890-75-4
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2E)-5-methyl-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]acetamide
CAS 54890-75-4C21H17N3O3S
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(4-fluorophenyl)thiazol-2-yl)acetamide chemical structure, C19H12FN3O3S, CAS 477545-66-7
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(4-fluorophenyl)thiazol-2-yl)acetamide
CAS 477545-66-7C19H12FN3O3S
2-(1,3-Dioxoisoindol-2-yl)-N-(5-ethyl-4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C21H17N3O3S, CAS 600138-14-5
2-(1,3-Dioxoisoindol-2-yl)-N-(5-ethyl-4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 600138-14-5C21H17N3O3S
N-(4-(2,5-Dimethylphenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C21H17N3O3S, CAS 477545-72-5
N-(4-(2,5-Dimethylphenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 477545-72-5C21H17N3O3S
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(3-methoxyphenyl)thiazol-2-yl)acetamide chemical structure, C20H15N3O4S, CAS 536731-65-4
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(3-methoxyphenyl)thiazol-2-yl)acetamide
CAS 536731-65-4C20H15N3O4S
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)acetamide chemical structure, C19H11Cl2N3O3S, CAS 477569-07-6
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)acetamide
CAS 477569-07-6C19H11Cl2N3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methyl-N-(4-phenyl-1,3-thiazol-2-yl)pentanamide chemical structure, C23H21N3O3S, CAS 384801-03-0
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methyl-N-(4-phenyl-1,3-thiazol-2-yl)pentanamide
CAS 384801-03-0C23H21N3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2Z)-4-phenyl-1,3-thiazol-2(3H)-ylidene]propanamide chemical structure, C20H15N3O3S, CAS 199282-01-4
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2Z)-4-phenyl-1,3-thiazol-2(3H)-ylidene]propanamide
CAS 199282-01-4C20H15N3O3S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)-3-methylbutanamide chemical structure, C22H18BrN3O3S, CAS 347365-25-7
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)-3-methylbutanamide
CAS 347365-25-7C22H18BrN3O3S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)-4-methylpentanamide chemical structure, C23H20BrN3O3S, CAS 347365-26-8
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)-4-methylpentanamide
CAS 347365-26-8C23H20BrN3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2E)-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]propanamide chemical structure, C21H17N3O3S, CAS 347366-65-8
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2E)-4-(4-methylphenyl)-1,3-thiazol-2(3H)-ylidene]propanamide
CAS 347366-65-8C21H17N3O3S
2-(1,3-Dioxoisoindolin-2-yl)-3-methyl-N-(4-(p-tolyl)thiazol-2-yl)butanamide chemical structure, C23H21N3O3S, CAS 329226-66-6
2-(1,3-Dioxoisoindolin-2-yl)-3-methyl-N-(4-(p-tolyl)thiazol-2-yl)butanamide
CAS 329226-66-6C23H21N3O3S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]butanamide chemical structure, C24H23N3O3S, CAS 347366-72-7
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]butanamide
CAS 347366-72-7C24H23N3O3S
N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C21H17N3O3S, CAS 476298-60-9
N-(4-(2,4-Dimethylphenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 476298-60-9C21H17N3O3S
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(4-ethylphenyl)thiazol-2-yl)acetamide chemical structure, C21H17N3O3S, CAS 477545-63-4
2-(1,3-Dioxoisoindolin-2-yl)-N-(4-(4-ethylphenyl)thiazol-2-yl)acetamide
CAS 477545-63-4C21H17N3O3S
N-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C19H11Cl2N3O3S, CAS 476298-65-4
N-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 476298-65-4C19H11Cl2N3O3S
N-(5-Acetyl-4-phenylthiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C21H15N3O4S, CAS 477545-67-8
N-(5-Acetyl-4-phenylthiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 477545-67-8C21H15N3O4S
2-(1,3-Dioxoisoindol-2-yl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C19H12IN3O3S, CAS 477545-68-9
2-(1,3-Dioxoisoindol-2-yl)-N-[4-(4-iodophenyl)-1,3-thiazol-2-yl]acetamide
CAS 477545-68-9C19H12IN3O3S
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)acetamide chemical structure, C21H17N3O5S, CAS 476298-62-1
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(1,3-dioxoisoindol-2-yl)acetamide
CAS 476298-62-1C21H17N3O5S
N-(4-(4-(tert-Butyl)phenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C23H21N3O3S, CAS 476319-47-8
N-(4-(4-(tert-Butyl)phenyl)thiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 476319-47-8C23H21N3O3S