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Murcko scaffold

Ring system with 3 rings and 17 atoms

160 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 17
Chemicals: 160
With full pages: 36

Scaffold SMILES

O=c1cccc2c(c1)CCCc1ccccc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cccc2c(c1)CCCc1ccccc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 160 chemicals

1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo(a)heptalen-9-one chemical structure, C21H25NO5, CAS 102491-77-0

1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo(a)heptalen-9-one

CAS 102491-77-0C₂₁H₂₅NO₅

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide chemical structure, C22H25NO6, CAS 54192-66-4

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide

CAS 54192-66-4C₂₂H₂₅NO₆

Colchicine chemical structure, C22H25NO6, CAS 64-86-8

CAS 64-86-8C₂₂H₂₅NO₆

7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one chemical structure, C21H23NO6, CAS 102491-69-0

7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one

CAS 102491-69-0C₂₁H₂₃NO₆

Colchiceine, N-deacetyl-N-methyl- chemical structure, C20H23NO5, CAS 518-11-6

Colchiceine, N-deacetyl-N-methyl-

CAS 518-11-6C₂₀H₂₃NO₅

6,7-Dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one chemical structure, C20H22O5, CAS 1420-08-2

6,7-Dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one

CAS 1420-08-2C₂₀H₂₂O₅

Thiocolchicine chemical structure, C22H25NO5S, CAS 2730-71-4

CAS 2730-71-4C₂₂H₂₅NO₅S

Colchicine, N-deacetyl-10-thio- chemical structure, C20H23NO4S, CAS 2731-16-0

Colchicine, N-deacetyl-10-thio-

CAS 2731-16-0C₂₀H₂₃NO₄S

N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]formamide chemical structure, C21H23NO5S

N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]formamide

C₂₁H₂₃NO₅S

N-((7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylamino)-9-oxobenzo(a)heptalen-7-yl)acetamide chemical structure, C22H26N2O5, CAS 2826-80-4

N-((7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylamino)-9-oxobenzo(a)heptalen-7-yl)acetamide

CAS 2826-80-4C₂₂H₂₆N₂O₅

N-((7S)-10-Amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide chemical structure, C21H24N2O5, CAS 3123-89-5

N-((7S)-10-Amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide

CAS 3123-89-5C₂₁H₂₄N₂O₅

1-Demethylcolchicine chemical structure, C21H23NO6, CAS 3464-68-4

1-Demethylcolchicine

CAS 3464-68-4C₂₁H₂₃NO₆

(7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one chemical structure, C20H23NO5, CAS 3476-50-4

(7S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one

CAS 3476-50-4C₂₀H₂₃NO₅

7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one chemical structure, C19H21NO5, CAS 68296-64-0

7-Amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

CAS 68296-64-0C₁₉H₂₁NO₅

Colchicine, 10-demethoxy-10-(diethylamino)- chemical structure, C25H32N2O5, CAS 6962-03-4

Colchicine, 10-demethoxy-10-(diethylamino)-

CAS 6962-03-4C₂₅H₃₂N₂O₅

(-)-2-Demethylcolchicine chemical structure, C21H23NO6, CAS 7336-36-9

(-)-2-Demethylcolchicine

CAS 7336-36-9C₂₁H₂₃NO₆

N-Methyl-N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide chemical structure, C23H27NO6, CAS 7336-40-5

N-Methyl-N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide

CAS 7336-40-5C₂₃H₂₇NO₆

Colchicine, N-deacetyl-N,N-dimethyl- chemical structure, C22H27NO5, CAS 7336-44-9

Colchicine, N-deacetyl-N,N-dimethyl-

CAS 7336-44-9C₂₂H₂₇NO₅

N-Deacetyl-N-formylcolchicine chemical structure, C21H23NO6, CAS 7411-12-3

N-Deacetyl-N-formylcolchicine

CAS 7411-12-3C₂₁H₂₃NO₆

N-Methyl-N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)formamide chemical structure, C22H25NO6, CAS 14686-61-4

N-Methyl-N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)formamide

CAS 14686-61-4C₂₂H₂₅NO₆

Colchicine, 17,17,17-trifluoro- chemical structure, C22H22F3NO6, CAS 26195-65-3

Colchicine, 17,17,17-trifluoro-

CAS 26195-65-3C₂₂H₂₂F₃NO₆

Colchicine, 17-fluoro- chemical structure, C22H24FNO6, CAS 26195-68-6

Colchicine, 17-fluoro-

CAS 26195-68-6C₂₂H₂₄FNO₆

Chlorcolchicine chemical structure, C22H24ClNO6, CAS 26279-89-0

Chlorcolchicine

CAS 26279-89-0C₂₂H₂₄ClNO₆

Carbamic acid, (5,6,7,9-tetrahydro-10-(methylthio)-9-oxo-1,2,3-trimethoxybenzo(a)heptalen-7-yl)-, ethyl ester, (S)- chemical structure, C23H27NO6S, CAS 63620-51-9

Carbamic acid, (5,6,7,9-tetrahydro-10-(methylthio)-9-oxo-1,2,3-trimethoxybenzo(a)heptalen-7-yl)-, ethyl ester, (S)-

CAS 63620-51-9C₂₃H₂₇NO₆S