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Murcko scaffold

Ring system with 6 rings and 30 atoms

11 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
30
Chemicals
11
With full pages
4
Scaffold SMILES

O=C1Nc2ccccc2C12NCC(c1ccccc1)C21COc2ccccc2C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C12NCC(c1ccccc1)C21COc2ccccc2C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

Chroman-4'-one-3'-spiro-3-N-methyl-4-(4-methylphenyl)-pyrrolidine-2-spiro-3"-oxindole chemical structure, C27H24N2O3, CAS 1164542-34-0
Chroman-4'-one-3'-spiro-3-N-methyl-4-(4-methylphenyl)-pyrrolidine-2-spiro-3"-oxindole
CAS 1164542-34-0C27H24N2O3
1'-Methyl-4'-phenyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H22N2O3, CAS 1164512-30-4
1'-Methyl-4'-phenyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1164512-30-4C26H22N2O3
4'-(2-Fluorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H21FN2O3, CAS 1177506-85-2
4'-(2-Fluorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1177506-85-2C26H21FN2O3
4'-(4-Chloro-3-nitrophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H20ClN3O5, CAS 1177601-98-7
4'-(4-Chloro-3-nitrophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1177601-98-7C26H20ClN3O5
4'-(2,4-Dichlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H20Cl2N2O3, CAS 1212332-83-6
4'-(2,4-Dichlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1212332-83-6C26H20Cl2N2O3
Chroman-4'-one-3'-spiro-3-N-methyl-4-(4-cyanophenyl)-pyrrolidine-2-spiro-3"-oxindole chemical structure, C27H21N3O3, CAS 1164462-71-8
Chroman-4'-one-3'-spiro-3-N-methyl-4-(4-cyanophenyl)-pyrrolidine-2-spiro-3"-oxindole
CAS 1164462-71-8C27H21N3O3
4'-(3,4-Dichlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H20Cl2N2O3, CAS 1797910-69-0
4'-(3,4-Dichlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1797910-69-0C26H20Cl2N2O3
4'-(2-Bromophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H21BrN2O3, CAS 1177910-05-2
4'-(2-Bromophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1177910-05-2C26H21BrN2O3
1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C27H21F3N2O3, CAS 1177520-27-2
1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1177520-27-2C27H21F3N2O3
1'-Methyl-4'-(3-nitrophenyl)-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H21N3O5, CAS 1797898-37-3
1'-Methyl-4'-(3-nitrophenyl)-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1797898-37-3C26H21N3O5
4'-(2-Chlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione chemical structure, C26H21ClN2O3, CAS 1164457-72-0
4'-(2-Chlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione
CAS 1164457-72-0C26H21ClN2O3