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Murcko scaffold

1-(Phenoxyacetyl)piperazine scaffold

269 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
269
With full pages
27
Scaffold SMILES

O=C(COc1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenoxyacetyl)piperazine page
Murcko scaffold O=C(COc1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 269 chemicals

Ethyl 4-[2-(4-chloro-3-methylphenoxy)acetyl]piperazine-1-carboxylate chemical structure, C16H21ClN2O4, CAS 429627-73-6
Ethyl 4-[2-(4-chloro-3-methylphenoxy)acetyl]piperazine-1-carboxylate
CAS 429627-73-6C16H21ClN2O4
2-(2,4-Dichlorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H16Cl2N2O2, CAS 346720-30-7
2-(2,4-Dichlorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 346720-30-7C13H16Cl2N2O2
2-(4-Chlorophenoxy)-1-(4-methylsulfonylpiperazin-1-yl)ethanone chemical structure, C13H17ClN2O4S, CAS 333757-86-1
2-(4-Chlorophenoxy)-1-(4-methylsulfonylpiperazin-1-yl)ethanone
CAS 333757-86-1C13H17ClN2O4S
1-(4-Ethylsulfonylpiperazin-1-yl)-2-(4-methoxyphenoxy)ethanone chemical structure, C15H22N2O5S, CAS 428827-94-5
1-(4-Ethylsulfonylpiperazin-1-yl)-2-(4-methoxyphenoxy)ethanone
CAS 428827-94-5C15H22N2O5S
2-(4-Methylphenoxy)-1-(4-propylsulfonylpiperazin-1-yl)ethanone chemical structure, C16H24N2O4S, CAS 428838-04-4
2-(4-Methylphenoxy)-1-(4-propylsulfonylpiperazin-1-yl)ethanone
CAS 428838-04-4C16H24N2O4S
Ethyl 4-[2-(4-chloro-2-methylphenoxy)acetyl]piperazine-1-carboxylate chemical structure, C16H21ClN2O4, CAS 351976-89-1
Ethyl 4-[2-(4-chloro-2-methylphenoxy)acetyl]piperazine-1-carboxylate
CAS 351976-89-1C16H21ClN2O4
Ethyl 4-[(4-chlorophenoxy)acetyl]piperazine-1-carboxylate chemical structure, C15H19ClN2O4, CAS 330459-53-5
Ethyl 4-[(4-chlorophenoxy)acetyl]piperazine-1-carboxylate
CAS 330459-53-5C15H19ClN2O4
2-Phenoxy-1-(4-propylsulfonylpiperazin-1-yl)ethanone chemical structure, C15H22N2O4S, CAS 441745-99-9
2-Phenoxy-1-(4-propylsulfonylpiperazin-1-yl)ethanone
CAS 441745-99-9C15H22N2O4S
2-(4-Chlorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H17ClN2O2, CAS 14683-71-7
2-(4-Chlorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 14683-71-7C13H17ClN2O2
1-[(3-Methylphenoxy)acetyl]-4-(methylsulfonyl)piperazine chemical structure, C14H20N2O4S, CAS 423753-95-1
1-[(3-Methylphenoxy)acetyl]-4-(methylsulfonyl)piperazine
CAS 423753-95-1C14H20N2O4S
2-(4-Bromo-3,5-dimethylphenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C15H21BrN2O2, CAS 433949-48-5
2-(4-Bromo-3,5-dimethylphenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 433949-48-5C15H21BrN2O2
2-(4-Fluorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C13H17FN2O2, CAS 499134-36-0
2-(4-Fluorophenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 499134-36-0C13H17FN2O2
1-(4-Ethylsulfonylpiperazin-1-yl)-2-phenoxyethanone chemical structure, C14H20N2O4S, CAS 428848-94-6
1-(4-Ethylsulfonylpiperazin-1-yl)-2-phenoxyethanone
CAS 428848-94-6C14H20N2O4S
1-(Phenoxyacetyl)piperazine chemical structure, C12H16N2O2, CAS 92114-37-9
1-(Phenoxyacetyl)piperazine
CAS 92114-37-9C12H16N2O2
Ethyl 4-[(2-methoxyphenoxy)acetyl]piperazine-1-carboxylate chemical structure, C16H22N2O5, CAS 442651-11-8
Ethyl 4-[(2-methoxyphenoxy)acetyl]piperazine-1-carboxylate
CAS 442651-11-8C16H22N2O5
1-[(4-Chloro-2-methylphenoxy)acetyl]-4-methylpiperazine chemical structure, C14H19ClN2O2, CAS 101991-85-9
1-[(4-Chloro-2-methylphenoxy)acetyl]-4-methylpiperazine
CAS 101991-85-9C14H19ClN2O2
2-(4-Methoxyphenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C14H20N2O3, CAS 359595-58-7
2-(4-Methoxyphenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 359595-58-7C14H20N2O3
2-(3-Methylphenoxy)-1-(4-propylsulfonylpiperazin-1-yl)ethanone chemical structure, C16H24N2O4S, CAS 428845-98-1
2-(3-Methylphenoxy)-1-(4-propylsulfonylpiperazin-1-yl)ethanone
CAS 428845-98-1C16H24N2O4S
2-(3,4-Dimethylphenoxy)-1-(4-methylpiperazin-1-yl)ethanone chemical structure, C15H22N2O2, CAS 462088-34-2
2-(3,4-Dimethylphenoxy)-1-(4-methylpiperazin-1-yl)ethanone
CAS 462088-34-2C15H22N2O2
4-tert-Butylphenyl 2-(4-methyl-1-piperazinyl)-2-oxoethyl ether chemical structure, C17H26N2O2, CAS 452362-64-0
4-tert-Butylphenyl 2-(4-methyl-1-piperazinyl)-2-oxoethyl ether
CAS 452362-64-0C17H26N2O2
1-(4-Methylsulfonylpiperazin-1-yl)-2-phenoxyethanone chemical structure, C13H18N2O4S, CAS 333757-41-8
1-(4-Methylsulfonylpiperazin-1-yl)-2-phenoxyethanone
CAS 333757-41-8C13H18N2O4S
1-[(4-Bromophenoxy)acetyl]-4-methylpiperazine chemical structure, C13H17BrN2O2, CAS 425655-02-3
1-[(4-Bromophenoxy)acetyl]-4-methylpiperazine
CAS 425655-02-3C13H17BrN2O2
2-(4-Methoxyphenoxy)-1-(4-methylsulfonylpiperazin-1-yl)ethanone chemical structure, C14H20N2O5S, CAS 522650-36-8
2-(4-Methoxyphenoxy)-1-(4-methylsulfonylpiperazin-1-yl)ethanone
CAS 522650-36-8C14H20N2O5S
3-Methyl-1-[4-[2-(3-methylphenoxy)acetyl]piperazin-1-yl]butan-1-one chemical structure, C18H26N2O3, CAS 423744-99-4
3-Methyl-1-[4-[2-(3-methylphenoxy)acetyl]piperazin-1-yl]butan-1-one
CAS 423744-99-4C18H26N2O3