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Murcko scaffold

Ring system with 2 rings and 17 atoms

68 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
68
With full pages
6
Scaffold SMILES

O=C(Cn1ccccc1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1ccccc1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 68 chemicals

2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-methylphenyl)acetamide chemical structure, C17H17N3O2, CAS 663200-52-0
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-methylphenyl)acetamide
CAS 663200-52-0C17H17N3O2
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2-ethylphenyl)acetamide chemical structure, C19H21N3O3, CAS 727422-00-6
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2-ethylphenyl)acetamide
CAS 727422-00-6C19H21N3O3
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2,4-dichlorophenyl)acetamide chemical structure, C17H15Cl2N3O3, CAS 663936-16-1
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2,4-dichlorophenyl)acetamide
CAS 663936-16-1C17H15Cl2N3O3
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2,3-dimethylphenyl)acetamide chemical structure, C19H21N3O3, CAS 797767-97-6
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(2,3-dimethylphenyl)acetamide
CAS 797767-97-6C19H21N3O3
N-(2-Bromo-4,5-dimethylphenyl)-2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1(2H)-yl]acetamide chemical structure, C19H20BrN3O3, CAS 801226-39-1
N-(2-Bromo-4,5-dimethylphenyl)-2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1(2H)-yl]acetamide
CAS 801226-39-1C19H20BrN3O3
N-(4-Methoxyphenyl)-2-[2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-1-yl]acetamide chemical structure, C15H13F3N2O3, CAS 446826-65-9
N-(4-Methoxyphenyl)-2-[2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-1-yl]acetamide
CAS 446826-65-9C15H13F3N2O3
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-isopropylphenyl)acetamide chemical structure, C19H21N3O2, CAS 266337-81-9
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-isopropylphenyl)acetamide
CAS 266337-81-9C19H21N3O2
N-(3-Chlorophenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C16H14ClN3O2, CAS 266337-83-1
N-(3-Chlorophenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide
CAS 266337-83-1C16H14ClN3O2
N-(2-Chloro-4-methylphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C17H16ClN3O2, CAS 897772-98-4
N-(2-Chloro-4-methylphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide
CAS 897772-98-4C17H16ClN3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-(trifluoromethyl)phenyl)acetamide chemical structure, C17H14F3N3O2, CAS 266337-82-0
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-(trifluoromethyl)phenyl)acetamide
CAS 266337-82-0C17H14F3N3O2
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(3-methylphenyl)acetamide chemical structure, C18H19N3O3, CAS 727421-99-0
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(3-methylphenyl)acetamide
CAS 727421-99-0C18H19N3O3
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C17H17N3O3, CAS 897769-98-1
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide
CAS 897769-98-1C17H17N3O3
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2,4-difluorophenyl)acetamide chemical structure, C16H13F2N3O2, CAS 897773-02-3
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2,4-difluorophenyl)acetamide
CAS 897773-02-3C16H13F2N3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(5-fluoro-2-methylphenyl)acetamide chemical structure, C17H16FN3O2, CAS 878677-68-0
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(5-fluoro-2-methylphenyl)acetamide
CAS 878677-68-0C17H16FN3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C18H19N3O3, CAS 915869-63-5
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-methoxy-5-methylphenyl)acetamide
CAS 915869-63-5C18H19N3O3
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-[2-(difluoromethoxy)phenyl]acetamide chemical structure, C18H17F2N3O4, CAS 897546-70-2
2-[3-Cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-[2-(difluoromethoxy)phenyl]acetamide
CAS 897546-70-2C18H17F2N3O4
N-(5-Chloro-2-methoxyphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl)acetamide chemical structure, C17H16ClN3O3, CAS 878677-28-2
N-(5-Chloro-2-methoxyphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl)acetamide
CAS 878677-28-2C17H16ClN3O3
N-(5-Chloro-2-methylphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C17H16ClN3O2, CAS 876718-21-7
N-(5-Chloro-2-methylphenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide
CAS 876718-21-7C17H16ClN3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C17H17N3O3, CAS 876718-24-0
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-methoxyphenyl)acetamide
CAS 876718-24-0C17H17N3O3
N-(2-Chlorophenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide chemical structure, C16H14ClN3O2, CAS 876718-29-5
N-(2-Chlorophenyl)-2-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)acetamide
CAS 876718-29-5C16H14ClN3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-ethoxyphenyl)acetamide chemical structure, C18H19N3O3, CAS 878677-30-6
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(4-ethoxyphenyl)acetamide
CAS 878677-30-6C18H19N3O3
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-fluorophenyl)acetamide chemical structure, C16H14FN3O2, CAS 878677-52-2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1-yl)-N-(2-fluorophenyl)acetamide
CAS 878677-52-2C16H14FN3O2
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C17H17N3O3, CAS 878677-32-8
2-(3-Cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 878677-32-8C17H17N3O3
Ethyl 4-[[2-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl)acetyl]amino]benzoate chemical structure, C19H19N3O4, CAS 878677-34-0
Ethyl 4-[[2-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl)acetyl]amino]benzoate
CAS 878677-34-0C19H19N3O4