Murcko scaffold
8-(Phenylsulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane scaffold
16 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 27
- Chemicals
- 16
- With full pages
- 3
Scaffold SMILES
O=S(=O)(c1ccccc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 16 of 16 chemicals
![8-((4-Fluoro-2-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H21FN2O5S3, CAS 898453-24-2](/s/WONOORGJPAKBMR-UHFFFAOYSA-N.svg)
8-((4-Fluoro-2-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-24-2C18H21FN2O5S3
![8-((4-Fluoro-3-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H21FN2O5S3, CAS 898425-31-5](/s/ZFAYPJJNPSNAFK-UHFFFAOYSA-N.svg)
8-((4-Fluoro-3-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-31-5C18H21FN2O5S3
![4-(Thiophen-2-ylsulfonyl)-8-tosyl-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H22N2O5S3, CAS 898408-49-6](/s/GVQNQKTUBJWPKZ-UHFFFAOYSA-N.svg)
4-(Thiophen-2-ylsulfonyl)-8-tosyl-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898408-49-6C18H22N2O5S3
![8-((3,4-Dimethoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C19H24N2O7S3, CAS 898408-44-1](/s/HIVHADVKZZOYMS-UHFFFAOYSA-N.svg)
8-((3,4-Dimethoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898408-44-1C19H24N2O7S3
![8-(Mesitylsulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C20H26N2O5S3, CAS 898453-20-8](/s/WYAYIDGAQFSVLT-UHFFFAOYSA-N.svg)
8-(Mesitylsulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-20-8C20H26N2O5S3
![8-((4-Methoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H22N2O6S3, CAS 903278-14-8](/s/VJSSRQCLMZCRBR-UHFFFAOYSA-N.svg)
8-((4-Methoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 903278-14-8C18H22N2O6S3
![8-((4-Methoxy-3-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C19H24N2O6S3, CAS 906155-38-2](/s/LQRDTGHMEMIERW-UHFFFAOYSA-N.svg)
8-((4-Methoxy-3-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 906155-38-2C19H24N2O6S3
![8-((2,5-Dimethylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C19H24N2O5S3, CAS 898453-26-4](/s/WIUGVRPLAFXFQQ-UHFFFAOYSA-N.svg)
8-((2,5-Dimethylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-26-4C19H24N2O5S3
![8-((2,5-Dimethoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C19H24N2O7S3, CAS 898425-33-7](/s/BDZBKSPOHDKBQQ-UHFFFAOYSA-N.svg)
8-((2,5-Dimethoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-33-7C19H24N2O7S3
![8-((2-Methoxy-5-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C19H24N2O6S3, CAS 898453-28-6](/s/TUGLRKWACXUSIH-UHFFFAOYSA-N.svg)
8-((2-Methoxy-5-methylphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-28-6C19H24N2O6S3
![8-((5-Fluoro-2-methoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H21FN2O6S3, CAS 898425-35-9](/s/LSHPMVDLNPXAFF-UHFFFAOYSA-N.svg)
8-((5-Fluoro-2-methoxyphenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-35-9C18H21FN2O6S3
![8-((2,5-Difluorophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H18F2N2O5S3, CAS 898453-18-4](/s/OVEFVEHXNNFUJO-UHFFFAOYSA-N.svg)
8-((2,5-Difluorophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-18-4C17H18F2N2O5S3
![8-((4-Fluorophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H19FN2O5S3, CAS 898425-27-9](/s/NRXHUQJVINTVQP-UHFFFAOYSA-N.svg)
8-((4-Fluorophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-27-9C17H19FN2O5S3
![8-(Phenylsulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H20N2O5S3, CAS 898425-29-1](/s/YIIZHWPNUNFABW-UHFFFAOYSA-N.svg)
8-(Phenylsulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-29-1C17H20N2O5S3
![8-(4-Chlorophenyl)sulfonyl-4-(2-thienylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H19ClN2O5S3, CAS 898453-22-0](/s/LPJQKTWSPBSDSL-UHFFFAOYSA-N.svg)
8-(4-Chlorophenyl)sulfonyl-4-(2-thienylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898453-22-0C17H19ClN2O5S3
![8-((4-Nitrophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H19N3O7S3, CAS 898425-30-4](/s/XQOQGHYWAOXWDQ-UHFFFAOYSA-N.svg)
8-((4-Nitrophenyl)sulfonyl)-4-(thiophen-2-ylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-30-4C17H19N3O7S3