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Murcko scaffold

Indolizino(1,2-b)quinolin-9(11H)-one scaffold

24 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
18
Chemicals
24
With full pages
6
Scaffold SMILES

O=c1cccc2n1Cc1cc3ccccc3nc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Indolizino(1,2-b)quinolin-9(11H)-one page
Murcko scaffold O=c1cccc2n1Cc1cc3ccccc3nc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Indolizino(1,2-b)quinolin-9(11H)-one chemical structure, C15H10N2O, CAS 30062-37-4
Indolizino(1,2-b)quinolin-9(11H)-one
CAS 30062-37-4C15H10N2O
Indolizino(1,2-b)quinoline-7-acetamide, 8-((acetyloxy)methyl)-alpha-ethyl-9,11-dihydro-alpha-hydroxy-N-(1-methylethyl)-9-oxo-, (S)- chemical structure, C25H27N3O5, CAS 69181-16-4
Indolizino(1,2-b)quinoline-7-acetamide, 8-((acetyloxy)methyl)-alpha-ethyl-9,11-dihydro-alpha-hydroxy-N-(1-methylethyl)-9-oxo-, (S)-
CAS 69181-16-4C25H27N3O5
2-Propenoic acid, (9k11-dihydro-7-(1-hydroxy-1-(((1-methylethyl)amino)carbonyl)propyl)-9-oxoindolizino(1,2-b)quinolin-8-yl)methyl ester, (S)- chemical structure, C26H27N3O5, CAS 69181-17-5
2-Propenoic acid, (9k11-dihydro-7-(1-hydroxy-1-(((1-methylethyl)amino)carbonyl)propyl)-9-oxoindolizino(1,2-b)quinolin-8-yl)methyl ester, (S)-
CAS 69181-17-5C26H27N3O5
Hydrotopotecan chemical structure, C23H25N3O6, CAS 132877-29-3
Hydrotopotecan
CAS 132877-29-3C23H25N3O6
Indolizino(1,2-b)quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, disodium salt, (S)- chemical structure, C20H17N2Na2O6+, CAS 122842-26-6
Indolizino(1,2-b)quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha,2-dihydroxy-8-(hydroxymethyl)-9-oxo-, disodium salt, (S)-
CAS 122842-26-6C20H17N2Na2O6+
Mappicine chemical structure, C19H18N2O2, CAS 54318-59-1
Mappicine
CAS 54318-59-1C19H18N2O2
Nothapodytine B chemical structure, C19H16N2O2, CAS 55854-89-2
Nothapodytine B
CAS 55854-89-2C19H16N2O2
Secocamptothecin N-methylamide chemical structure, C21H21N3O4, CAS 35903-43-6
Secocamptothecin N-methylamide
CAS 35903-43-6C21H21N3O4
Ethyl 7-methoxy-9-oxo-9,11-dihydroindolizino(1,2-b)quinoline-8-carboxylate chemical structure, C19H16N2O4, CAS 32889-94-4
Ethyl 7-methoxy-9-oxo-9,11-dihydroindolizino(1,2-b)quinoline-8-carboxylate
CAS 32889-94-4C19H16N2O4
Methyl 8-methyl-9-oxo-11H-indolizino[1,2-b]quinoline-7-carboxylate chemical structure, C18H14N2O3, CAS 55854-85-8
Methyl 8-methyl-9-oxo-11H-indolizino[1,2-b]quinoline-7-carboxylate
CAS 55854-85-8C18H14N2O3
8-Methyl-9-oxo-9,11-dihydroindolizino(1,2-b)quinoline-7-carboxylic acid chemical structure, C17H12N2O3, CAS 57764-77-9
8-Methyl-9-oxo-9,11-dihydroindolizino(1,2-b)quinoline-7-carboxylic acid
CAS 57764-77-9C17H12N2O3
8-Ethylindolizino[1,2-b]quinolin-9(11H)-one chemical structure, C17H14N2O, CAS 39008-04-3
8-Ethylindolizino[1,2-b]quinolin-9(11H)-one
CAS 39008-04-3C17H14N2O
(2S)-2-[12-Ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoic acid chemical structure, C22H22N2O6, CAS 142677-15-4
(2S)-2-[12-Ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoic acid
CAS 142677-15-4C22H22N2O6
(2s)-2-Hydroxy-2-[8-(Hydroxymethyl)-9-Oxo-9,11-Dihydroindolizino[1,2-B]quinolin-7-Yl]butanoic Acid chemical structure, C20H18N2O5, CAS 34079-22-6
(2s)-2-Hydroxy-2-[8-(Hydroxymethyl)-9-Oxo-9,11-Dihydroindolizino[1,2-B]quinolin-7-Yl]butanoic Acid
CAS 34079-22-6C20H18N2O5
7-(1-Hydroxypropyl)-8-methyl-11H-indolizino[1,2-b]quinolin-9-one chemical structure, C19H18N2O2, CAS 54352-77-1
7-(1-Hydroxypropyl)-8-methyl-11H-indolizino[1,2-b]quinolin-9-one
CAS 54352-77-1C19H18N2O2
9,11-Dihydro-7-methyl-9-oxoindolizino[1,2-b]quinoline-8-carbonitrile chemical structure, C17H11N3O, CAS 66917-21-3
9,11-Dihydro-7-methyl-9-oxoindolizino[1,2-b]quinoline-8-carbonitrile
CAS 66917-21-3C17H11N3O
Indolizino(1,2-b)quinoline-7-acetic acid, 1-amino-alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt chemical structure, C20H18N3NaO5, CAS 122842-24-4
Indolizino(1,2-b)quinoline-7-acetic acid, 1-amino-alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt
CAS 122842-24-4C20H18N3NaO5
Sodium (R)-2-hydroxy-2-(8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)butanoate chemical structure, C20H17N2NaO5, CAS 1531628-77-9
Sodium (R)-2-hydroxy-2-(8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)butanoate
CAS 1531628-77-9C20H17N2NaO5
Camptothecin sodium chemical structure, C20H17N2NaO5, CAS 25387-67-1
Camptothecin sodium
CAS 25387-67-1C20H17N2NaO5
Topotecan carboxylic acid sodium salt chemical structure, C23H24N3NaO6, CAS 123949-08-6
Topotecan carboxylic acid sodium salt
CAS 123949-08-6C23H24N3NaO6
Topotecan-d6 carboxylic acid sodium salt chemical structure, C23H24N3NaO6, CAS 1263470-27-4
Topotecan-d6 carboxylic acid sodium salt
CAS 1263470-27-4C23H24N3NaO6
Cositecan carboxylate chemical structure, C25H30N2O5Si, CAS 807621-24-5
Cositecan carboxylate
CAS 807621-24-5C25H30N2O5Si
Sodium 2-[1-[[bis(trideuteriomethyl)amino]methyl]-2-hydroxy-8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate chemical structure, C23H24N3NaO6
Sodium 2-[1-[[bis(trideuteriomethyl)amino]methyl]-2-hydroxy-8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate
C23H24N3NaO6
(S)-2-Hydroxy-2-(8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)butanoic acid hydrochloride chemical structure, C20H19ClN2O5, CAS 2577435-10-8
(S)-2-Hydroxy-2-(8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)butanoic acid hydrochloride
CAS 2577435-10-8C20H19ClN2O5