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Murcko scaffold

1-(Thiophene-2-carbonyl)pyrrolidine scaffold

100 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
100
With full pages
9
Scaffold SMILES

O=C(c1cccs1)N1CCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thiophene-2-carbonyl)pyrrolidine page
Murcko scaffold O=C(c1cccs1)N1CCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 100 chemicals

Ethyl 2-amino-4-methyl-5-(pyrrolidin-1-ylcarbonyl)thiophene-3-carboxylate chemical structure, C13H18N2O3S, CAS 347353-07-5
Ethyl 2-amino-4-methyl-5-(pyrrolidin-1-ylcarbonyl)thiophene-3-carboxylate
CAS 347353-07-5C13H18N2O3S
(2S)-1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid chemical structure, C10H11NO3S
(2S)-1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid
C10H11NO3S
(2R)-1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid chemical structure, C10H11NO3S, CAS 1164123-34-5
(2R)-1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid
CAS 1164123-34-5C10H11NO3S
1-(Thiophene-2-carbonyl)pyrrolidine chemical structure, C9H11NOS, CAS 69340-21-2
1-(Thiophene-2-carbonyl)pyrrolidine
CAS 69340-21-2C9H11NOS
(5-Ethylthiophen-2-yl)(pyrrolidin-1-yl)methanone chemical structure, C11H15NOS, CAS 774588-59-9
(5-Ethylthiophen-2-yl)(pyrrolidin-1-yl)methanone
CAS 774588-59-9C11H15NOS
(5-Chlorothiophen-2-yl)-pyrrolidin-1-ylmethanone chemical structure, C9H10ClNOS, CAS 717872-42-9
(5-Chlorothiophen-2-yl)-pyrrolidin-1-ylmethanone
CAS 717872-42-9C9H10ClNOS
1-(2-Thienylcarbonyl)-l-proline methyl ester chemical structure, C11H13NO3S, CAS 1085465-84-4
1-(2-Thienylcarbonyl)-l-proline methyl ester
CAS 1085465-84-4C11H13NO3S
1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid chemical structure, C10H11NO3S, CAS 117918-58-8
1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid
CAS 117918-58-8C10H11NO3S
[5-(tert-Butyl)-2-thienyl](1-pyrrolidinyl)methanone chemical structure, C13H19NOS, CAS 260354-92-5
[5-(tert-Butyl)-2-thienyl](1-pyrrolidinyl)methanone
CAS 260354-92-5C13H19NOS
Methyl 2-acetamido-4-methyl-5-(pyrrolidine-1-carbonyl)thiophene-3-carboxylate chemical structure, C14H18N2O4S, CAS 915887-04-6
Methyl 2-acetamido-4-methyl-5-(pyrrolidine-1-carbonyl)thiophene-3-carboxylate
CAS 915887-04-6C14H18N2O4S
(5-Bromothiophen-2-yl)(2-methylpyrrolidin-1-yl)methanone chemical structure, C10H12BrNOS, CAS 1247358-86-6
(5-Bromothiophen-2-yl)(2-methylpyrrolidin-1-yl)methanone
CAS 1247358-86-6C10H12BrNOS
(4-Bromothiophen-2-yl)(pyrrolidin-1-yl)methanone chemical structure, C9H10BrNOS, CAS 827591-20-8
(4-Bromothiophen-2-yl)(pyrrolidin-1-yl)methanone
CAS 827591-20-8C9H10BrNOS
5-[(2-Ethyl-1-pyrrolidinyl)carbonyl]-2-thiophenecarboxylic acid chemical structure, C12H15NO3S, CAS 1184110-35-7
5-[(2-Ethyl-1-pyrrolidinyl)carbonyl]-2-thiophenecarboxylic acid
CAS 1184110-35-7C12H15NO3S
1-(5-Chlorothiophene-2-carbonyl)pyrrolidine-2-carboxylic acid chemical structure, C10H10ClNO3S, CAS 351493-11-3
1-(5-Chlorothiophene-2-carbonyl)pyrrolidine-2-carboxylic acid
CAS 351493-11-3C10H10ClNO3S
5-(Pyrrolidine-1-carbonyl)thiophene-2-carboxylic acid chemical structure, C10H11NO3S, CAS 921596-93-2
5-(Pyrrolidine-1-carbonyl)thiophene-2-carboxylic acid
CAS 921596-93-2C10H11NO3S
[(2S)-2-(Aminomethyl)-1-pyrrolidinyl]-2-thienylmethanone chemical structure, C10H14N2OS, CAS 1217447-11-4
[(2S)-2-(Aminomethyl)-1-pyrrolidinyl]-2-thienylmethanone
CAS 1217447-11-4C10H14N2OS
Methyl 5-(pyrrolidine-1-carbonyl)thiophene-2-carboxylate chemical structure, C11H13NO3S, CAS 921596-43-2
Methyl 5-(pyrrolidine-1-carbonyl)thiophene-2-carboxylate
CAS 921596-43-2C11H13NO3S
1-(5-Chlorothiophene-2-carbonyl)-3-(trifluoromethyl)pyrrolidin-3-ol chemical structure, C10H9ClF3NO2S, CAS 1355823-01-6
1-(5-Chlorothiophene-2-carbonyl)-3-(trifluoromethyl)pyrrolidin-3-ol
CAS 1355823-01-6C10H9ClF3NO2S
5-(Pyrrolidine-1-carbonyl)thiophene-2-carbohydrazide chemical structure, C10H13N3O2S, CAS 921596-42-1
5-(Pyrrolidine-1-carbonyl)thiophene-2-carbohydrazide
CAS 921596-42-1C10H13N3O2S
(3-Aminopyrrolidin-1-yl)(5-methylthiophen-2-yl)methanone chemical structure, C10H14N2OS, CAS 1248662-55-6
(3-Aminopyrrolidin-1-yl)(5-methylthiophen-2-yl)methanone
CAS 1248662-55-6C10H14N2OS
(R)-(3-Hydroxypyrrolidin-1-yl)(3-methylthiophen-2-yl)methanone chemical structure, C10H13NO2S, CAS 1354009-00-9
(R)-(3-Hydroxypyrrolidin-1-yl)(3-methylthiophen-2-yl)methanone
CAS 1354009-00-9C10H13NO2S
(5-Bromothiophen-2-yl)(3-methylpyrrolidin-1-yl)methanone chemical structure, C10H12BrNOS, CAS 1250615-86-1
(5-Bromothiophen-2-yl)(3-methylpyrrolidin-1-yl)methanone
CAS 1250615-86-1C10H12BrNOS
(2-(Hydroxymethyl)pyrrolidin-1-yl)(3-methylthiophen-2-yl)methanone chemical structure, C11H15NO2S, CAS 1248216-97-8
(2-(Hydroxymethyl)pyrrolidin-1-yl)(3-methylthiophen-2-yl)methanone
CAS 1248216-97-8C11H15NO2S
(2-(Hydroxymethyl)pyrrolidin-1-yl)(thiophen-2-yl)methanone chemical structure, C10H13NO2S, CAS 1176058-91-5
(2-(Hydroxymethyl)pyrrolidin-1-yl)(thiophen-2-yl)methanone
CAS 1176058-91-5C10H13NO2S