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Murcko scaffold

1-(2-Thienylsulfonyl)pyrrolidine scaffold

91 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
91
With full pages
15
Scaffold SMILES

O=S(=O)(c1cccs1)N1CCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(2-Thienylsulfonyl)pyrrolidine page
Murcko scaffold O=S(=O)(c1cccs1)N1CCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

Dimethyl 3-methyl-5-(pyrrolidin-1-ylsulfonyl)thiophene-2,4-dicarboxylate chemical structure, C13H17NO6S2, CAS 612045-11-1
Dimethyl 3-methyl-5-(pyrrolidin-1-ylsulfonyl)thiophene-2,4-dicarboxylate
CAS 612045-11-1C13H17NO6S2
1-(2-Thienylsulfonyl)pyrrolidine chemical structure, C8H11NO2S2, CAS 358666-55-4
1-(2-Thienylsulfonyl)pyrrolidine
CAS 358666-55-4C8H11NO2S2
(2S)-1-Thiophen-2-ylsulfonylpyrrolidine-2-carboxylic acid chemical structure, C9H11NO4S2, CAS 82068-22-2
(2S)-1-Thiophen-2-ylsulfonylpyrrolidine-2-carboxylic acid
CAS 82068-22-2C9H11NO4S2
1-[(5-Chloro-2-thienyl)sulfonyl]pyrrolidine chemical structure, C8H10ClNO2S2, CAS 496778-08-6
1-[(5-Chloro-2-thienyl)sulfonyl]pyrrolidine
CAS 496778-08-6C8H10ClNO2S2
1-[(5-Bromo-2-thienyl)sulfonyl]pyrrolidine chemical structure, C8H10BrNO2S2, CAS 81597-72-0
1-[(5-Bromo-2-thienyl)sulfonyl]pyrrolidine
CAS 81597-72-0C8H10BrNO2S2
2-(5-(Pyrrolidine-1-sulfonyl)thiophen-2-yl)acetic acid chemical structure, C10H13NO4S2, CAS 726165-21-5
2-(5-(Pyrrolidine-1-sulfonyl)thiophen-2-yl)acetic acid
CAS 726165-21-5C10H13NO4S2
1-[(4-Bromo-5-chloro-2-thienyl)sulfonyl]pyrrolidine chemical structure, C8H9BrClNO2S2, CAS 259137-98-9
1-[(4-Bromo-5-chloro-2-thienyl)sulfonyl]pyrrolidine
CAS 259137-98-9C8H9BrClNO2S2
4-Hydroxy-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylic acid chemical structure, C9H11NO5S2, CAS 251310-43-7
4-Hydroxy-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylic acid
CAS 251310-43-7C9H11NO5S2
Methyl 4-hydroxy-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylate chemical structure, C10H13NO5S2, CAS 251310-46-0
Methyl 4-hydroxy-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylate
CAS 251310-46-0C10H13NO5S2
Methyl 4-chloro-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylate chemical structure, C10H12ClNO4S2, CAS 251310-47-1
Methyl 4-chloro-1-(2-thienylsulfonyl)-2-pyrrolidinecarboxylate
CAS 251310-47-1C10H12ClNO4S2
1-(Thiophene-2-sulfonyl)-pyrrolidine-2-carboxylic acid chemical structure, C9H11NO4S2, CAS 82068-23-3
1-(Thiophene-2-sulfonyl)-pyrrolidine-2-carboxylic acid
CAS 82068-23-3C9H11NO4S2
Proline, 1-((5-bromo-2-thienyl)sulfonyl)- chemical structure, C9H10BrNO4S2, CAS 1301738-60-2
Proline, 1-((5-bromo-2-thienyl)sulfonyl)-
CAS 1301738-60-2C9H10BrNO4S2
1-[(5-Methylthiophen-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid chemical structure, C10H13NO4S2, CAS 1008281-37-5
1-[(5-Methylthiophen-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid
CAS 1008281-37-5C10H13NO4S2
(1-((5-Bromothiophen-2-yl)sulfonyl)pyrrolidin-2-yl)methanol chemical structure, C9H12BrNO3S2, CAS 1022681-52-2
(1-((5-Bromothiophen-2-yl)sulfonyl)pyrrolidin-2-yl)methanol
CAS 1022681-52-2C9H12BrNO3S2
1-[(5-Chlorothien-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid chemical structure, C9H10ClNO4S2, CAS 1007999-30-5
1-[(5-Chlorothien-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid
CAS 1007999-30-5C9H10ClNO4S2
(2S)-1-(5-Chlorothiophene-2-sulfonyl)pyrrolidine-2-carboxylic acid chemical structure, C9H10ClNO4S2, CAS 1257437-06-1
(2S)-1-(5-Chlorothiophene-2-sulfonyl)pyrrolidine-2-carboxylic acid
CAS 1257437-06-1C9H10ClNO4S2
(5-(Pyrrolidin-1-ylsulfonyl)thiophen-2-yl)methanamine chemical structure, C9H14N2O2S2, CAS 923143-99-1
(5-(Pyrrolidin-1-ylsulfonyl)thiophen-2-yl)methanamine
CAS 923143-99-1C9H14N2O2S2
N1-allyl-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C14H19N3O4S2, CAS 896294-40-9
N1-allyl-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896294-40-9C14H19N3O4S2
N1-(2-(dimethylamino)ethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C15H24N4O4S2, CAS 896294-54-5
N1-(2-(dimethylamino)ethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896294-54-5C15H24N4O4S2
N1-butyl-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C15H23N3O4S2, CAS 896277-96-6
N1-butyl-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896277-96-6C15H23N3O4S2
N1-(2-methoxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C14H21N3O5S2, CAS 896278-04-9
N1-(2-methoxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896278-04-9C14H21N3O5S2
N1-(2-hydroxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C13H19N3O5S2, CAS 896278-36-7
N1-(2-hydroxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896278-36-7C13H19N3O5S2
N1-(2,2-dimethoxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide chemical structure, C15H23N3O6S2, CAS 896279-16-6
N1-(2,2-dimethoxyethyl)-N2-((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)oxalamide
CAS 896279-16-6C15H23N3O6S2
Ethyl 2-oxo-2-(((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)amino)acetate chemical structure, C13H18N2O5S2, CAS 896280-60-7
Ethyl 2-oxo-2-(((1-(thiophen-2-ylsulfonyl)pyrrolidin-2-yl)methyl)amino)acetate
CAS 896280-60-7C13H18N2O5S2