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Murcko scaffold

Ring system with 5 rings and 25 atoms

14 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
25
Chemicals
14
With full pages
11
Scaffold SMILES

O=c1c(=Cc2ccccc2)sc2nc(-c3cc4ccccc4o3)nn12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(=Cc2ccccc2)sc2nc(-c3cc4ccccc4o3)nn12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[(2-propoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one chemical structure, C23H19N3O3S, CAS 608491-11-8
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[(2-propoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
CAS 608491-11-8C23H19N3O3S
(5E)-5-(4-Butoxy-3-ethoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C26H25N3O4S, CAS 618078-22-1
(5E)-5-(4-Butoxy-3-ethoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 618078-22-1C26H25N3O4S
(5E)-5-(3,4-Diethoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C24H21N3O4S, CAS 797799-21-4
(5E)-5-(3,4-Diethoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 797799-21-4C24H21N3O4S
(5E)-5-(2-Butoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C24H21N3O3S, CAS 624725-98-0
(5E)-5-(2-Butoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 624725-98-0C24H21N3O3S
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[2-(pentyloxy)benzylidene][1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C25H23N3O3S, CAS 618080-71-0
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[2-(pentyloxy)benzylidene][1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 618080-71-0C25H23N3O3S
(5E)-5-(3-Ethoxy-4-propoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C25H23N3O4S, CAS 618078-25-4
(5E)-5-(3-Ethoxy-4-propoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 618078-25-4C25H23N3O4S
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(3,4,5-trimethoxybenzylidene)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C23H19N3O5S, CAS 606953-02-0
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(3,4,5-trimethoxybenzylidene)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606953-02-0C23H19N3O5S
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[4-(methylsulfanyl)benzylidene][1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C21H15N3O2S2, CAS 606962-43-0
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-[4-(methylsulfanyl)benzylidene][1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606962-43-0C21H15N3O2S2
(5E)-5-(5-Bromo-2-methoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C21H14BrN3O3S, CAS 606954-08-9
(5E)-5-(5-Bromo-2-methoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 606954-08-9C21H14BrN3O3S
(5Z)-2-(3-Methyl-1-benzofuran-2-yl)-5-(2-nitrobenzylidene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C20H12N4O4S, CAS 606958-39-8
(5Z)-2-(3-Methyl-1-benzofuran-2-yl)-5-(2-nitrobenzylidene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 606958-39-8C20H12N4O4S
(5E)-5-(4-Butoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C24H21N3O3S, CAS 606955-13-9
(5E)-5-(4-Butoxybenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606955-13-9C24H21N3O3S
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(4-propoxybenzylidene)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C23H19N3O3S, CAS 606954-91-0
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(4-propoxybenzylidene)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606954-91-0C23H19N3O3S
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(4-(pentyloxy)benzylidene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C25H23N3O3S, CAS 618077-63-7
(5E)-2-(3-Methyl-1-benzofuran-2-yl)-5-(4-(pentyloxy)benzylidene)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 618077-63-7C25H23N3O3S
(5Z)-5-(4-Ethylbenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C22H17N3O2S, CAS 606955-11-7
(5Z)-5-(4-Ethylbenzylidene)-2-(3-methyl-1-benzofuran-2-yl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606955-11-7C22H17N3O2S