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Murcko scaffold

Ring system with 4 rings and 25 atoms

16 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 16
With full pages: 2

Scaffold SMILES

O=C(Nc1cc(-c2ccccc2)cs1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1cc(-c2ccccc2)cs1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Methyl 4-(4-ethoxyphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C25H22N2O5S, CAS 444924-32-7

Methyl 4-(4-ethoxyphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 444924-32-7C₂₅H₂₂N₂O₅S

Ethyl 2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4-(3-methylphenyl)thiophene-3-carboxylate chemical structure, C25H21ClN2O4S, CAS 444924-84-9

Ethyl 2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-4-(3-methylphenyl)thiophene-3-carboxylate

CAS 444924-84-9C₂₅H₂₁ClN₂O₄S

Methyl 4-(4-butylphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C27H26N2O4S, CAS 444925-22-8

Methyl 4-(4-butylphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 444925-22-8C₂₇H₂₆N₂O₄S

Methyl 4-(2,4-dimethylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C26H24N2O4S, CAS 495376-11-9

Methyl 4-(2,4-dimethylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 495376-11-9C₂₆H₂₄N₂O₄S

Isopropyl 5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-4-(4-propylphenyl)-3-thiophenecarboxylate chemical structure, C29H30N2O4S, CAS 444934-34-3

Isopropyl 5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-4-(4-propylphenyl)-3-thiophenecarboxylate

CAS 444934-34-3C₂₉H₃₀N₂O₄S

Isopropyl 4-(3,4-dimethoxyphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C27H26N2O6S, CAS 514817-20-0

Isopropyl 4-(3,4-dimethoxyphenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 514817-20-0C₂₇H₂₆N₂O₆S

Methyl 4-(4-ethylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C26H24N2O4S, CAS 444935-37-9

Methyl 4-(4-ethylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 444935-37-9C₂₆H₂₄N₂O₄S

Ethyl 5-methyl-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-4-phenylthiophene-3-carboxylate chemical structure, C25H22N2O4S, CAS 514836-86-3

Ethyl 5-methyl-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-4-phenylthiophene-3-carboxylate

CAS 514836-86-3C₂₅H₂₂N₂O₄S

Propyl 4-(4-butylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C30H32N2O4S, CAS 514837-82-2

Propyl 4-(4-butylphenyl)-5-methyl-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 514837-82-2C₃₀H₃₂N₂O₄S

Propyl 4-(4-bromophenyl)-2-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C25H21BrN2O4S, CAS 514856-43-0

Propyl 4-(4-bromophenyl)-2-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}thiophene-3-carboxylate

CAS 514856-43-0C₂₅H₂₁BrN₂O₄S

Propyl 4-(4-tert-butylphenyl)-2-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-5-methylthiophene-3-carboxylate chemical structure, C30H30Cl2N2O4S, CAS 445018-16-6

Propyl 4-(4-tert-butylphenyl)-2-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-5-methylthiophene-3-carboxylate

CAS 445018-16-6C₃₀H₃₀Cl₂N₂O₄S

3-(2-Chloro-6-fluorophenyl)-N-(3-cyano-5-methyl-4-phenylthiophen-2-yl)-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C23H15ClFN3O2S, CAS 515123-31-6

3-(2-Chloro-6-fluorophenyl)-N-(3-cyano-5-methyl-4-phenylthiophen-2-yl)-5-methyl-1,2-oxazole-4-carboxamide

CAS 515123-31-6C₂₃H₁₅ClFN₃O₂S

Ethyl 4-(4-fluorophenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C24H19FN2O4S, CAS 545383-33-3

Ethyl 4-(4-fluorophenyl)-2-{[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino}-3-thiophenecarboxylate

CAS 545383-33-3C₂₄H₁₉FN₂O₄S

Propan-2-yl 4-(4-butan-2-ylphenyl)-2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-5-methylthiophene-3-carboxylate chemical structure, C30H31ClN2O4S, CAS 444925-66-0

Propan-2-yl 4-(4-butan-2-ylphenyl)-2-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-5-methylthiophene-3-carboxylate

CAS 444925-66-0C₃₀H₃₁ClN₂O₄S

Propan-2-yl 4-(4-butan-2-ylphenyl)-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]thiophene-3-carboxylate chemical structure, C29H30N2O4S, CAS 444934-22-9

Propan-2-yl 4-(4-butan-2-ylphenyl)-2-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]thiophene-3-carboxylate

CAS 444934-22-9C₂₉H₃₀N₂O₄S

Methyl 4-(4-sec-butylphenyl)-2-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)thiophene-3-carboxylate chemical structure, C27H24Cl2N2O4S, CAS 514837-98-0

Methyl 4-(4-sec-butylphenyl)-2-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)thiophene-3-carboxylate

CAS 514837-98-0C₂₇H₂₄Cl₂N₂O₄S