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Murcko scaffold

Ring system with 4 rings and 23 atoms

39 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
39
With full pages
2
Scaffold SMILES

O=C1NC2=C(C(=O)N(c3ccccc3)C2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC2=C(C(=O)N(c3ccccc3)C2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

1-Methyl-4-phenyl-6-p-tolyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C20H19N3O2, CAS 361986-48-3
1-Methyl-4-phenyl-6-p-tolyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 361986-48-3C20H19N3O2
1-Methyl-4,6-diphenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H17N3O2, CAS 339360-70-2
1-Methyl-4,6-diphenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 339360-70-2C19H17N3O2
6-(3-Chlorophenyl)-1-methyl-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H16ClN3O2, CAS 633281-62-6
6-(3-Chlorophenyl)-1-methyl-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 633281-62-6C19H16ClN3O2
4-(4-Hydroxyphenyl)-1-methyl-6-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H17N3O3, CAS 578755-68-7
4-(4-Hydroxyphenyl)-1-methyl-6-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 578755-68-7C19H17N3O3
1-Methyl-4-phenyl-6-[4-(trifluoromethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C20H16F3N3O3, CAS 695192-86-0
1-Methyl-4-phenyl-6-[4-(trifluoromethoxy)phenyl]-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 695192-86-0C20H16F3N3O3
6-(4-Ethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C21H20N4O4, CAS 879456-62-9
6-(4-Ethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879456-62-9C21H20N4O4
Ethyl 4-(1-methyl-2,5-dioxo-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl)benzoate chemical structure, C22H21N3O4, CAS 728035-84-5
Ethyl 4-(1-methyl-2,5-dioxo-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl)benzoate
CAS 728035-84-5C22H21N3O4
6-(4-Chlorophenyl)-1-methyl-4-phenyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H16ClN3O2, CAS 889970-86-9
6-(4-Chlorophenyl)-1-methyl-4-phenyl-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 889970-86-9C19H16ClN3O2
4-[4-(4-Methoxyphenyl)-1-methyl-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzenesulfonamide chemical structure, C20H20N4O5S, CAS 889960-41-2
4-[4-(4-Methoxyphenyl)-1-methyl-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzenesulfonamide
CAS 889960-41-2C20H20N4O5S
4-(1-Methyl-2,5-dioxo-4-phenyl-1,2,3,4,5,7-hexahydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)benzenesulfonamide chemical structure, C19H18N4O4S, CAS 728035-85-6
4-(1-Methyl-2,5-dioxo-4-phenyl-1,2,3,4,5,7-hexahydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)benzenesulfonamide
CAS 728035-85-6C19H18N4O4S
6-(4-Ethoxyphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C21H20N4O5, CAS 879461-71-9
6-(4-Ethoxyphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879461-71-9C21H20N4O5
6-(3,4-Dimethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C21H20N4O4, CAS 879474-32-5
6-(3,4-Dimethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879474-32-5C21H20N4O4
6-(3,5-Dimethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C21H20N4O4, CAS 879470-59-4
6-(3,5-Dimethylphenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879470-59-4C21H20N4O4
4-(4-Bromophenyl)-6-(4-ethoxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C21H20BrN3O3, CAS 899371-19-8
4-(4-Bromophenyl)-6-(4-ethoxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 899371-19-8C21H20BrN3O3
1-Methyl-4-(3-nitrophenyl)-6-[3-(trifluoromethyl)phenyl]-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C20H15F3N4O4, CAS 879444-10-7
1-Methyl-4-(3-nitrophenyl)-6-[3-(trifluoromethyl)phenyl]-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879444-10-7C20H15F3N4O4
3-[1-Methyl-4-(3-nitrophenyl)-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoic acid chemical structure, C20H16N4O6, CAS 879436-53-0
3-[1-Methyl-4-(3-nitrophenyl)-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoic acid
CAS 879436-53-0C20H16N4O6
6-(4-Ethoxyphenyl)-4-(4-methoxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C22H23N3O4, CAS 889973-77-7
6-(4-Ethoxyphenyl)-4-(4-methoxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 889973-77-7C22H23N3O4
4-(4-Bromophenyl)-6-(4-chlorophenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H15BrClN3O2, CAS 893765-06-5
4-(4-Bromophenyl)-6-(4-chlorophenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 893765-06-5C19H15BrClN3O2
6-(3-Chlorophenyl)-4-(4-hydroxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H16ClN3O3, CAS 696648-55-2
6-(3-Chlorophenyl)-4-(4-hydroxyphenyl)-1-methyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 696648-55-2C19H16ClN3O3
1-Methyl-6-(4-nitrophenyl)-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H16N4O4, CAS 728016-23-7
1-Methyl-6-(4-nitrophenyl)-4-phenyl-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 728016-23-7C19H16N4O4
4-(4-Bromophenyl)-1-methyl-6-(4-nitrophenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H15BrN4O4, CAS 728035-83-4
4-(4-Bromophenyl)-1-methyl-6-(4-nitrophenyl)-3,4,6,7-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 728035-83-4C19H15BrN4O4
Ethyl 4-[1-methyl-4-(3-nitrophenyl)-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoate chemical structure, C22H20N4O6, CAS 879440-44-5
Ethyl 4-[1-methyl-4-(3-nitrophenyl)-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoate
CAS 879440-44-5C22H20N4O6
6-(4-Chlorophenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione chemical structure, C19H15ClN4O4, CAS 879441-20-0
6-(4-Chlorophenyl)-1-methyl-4-(3-nitrophenyl)-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidine-2,5-dione
CAS 879441-20-0C19H15ClN4O4
4-[4-(4-Methoxyphenyl)-1-methyl-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoic acid chemical structure, C21H19N3O5, CAS 728035-87-8
4-[4-(4-Methoxyphenyl)-1-methyl-2,5-dioxo-4,7-dihydro-3H-pyrrolo[3,4-d]pyrimidin-6-yl]benzoic acid
CAS 728035-87-8C21H19N3O5