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Murcko scaffold

Thalidomide-piperidine scaffold

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
15
With full pages
2
Scaffold SMILES

O=C1CCC(N2C(=O)c3cccc(N4CCCCC4)c3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Thalidomide-piperidine page
Murcko scaffold O=C1CCC(N2C(=O)c3cccc(N4CCCCC4)c3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2154342-34-2
4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2154342-34-2C18H20N4O4
tert-Butyl N-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperidin-4-yl)carbamate chemical structure, C23H28N4O6, CAS 2154342-18-2
tert-Butyl N-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperidin-4-yl)carbamate
CAS 2154342-18-2C23H28N4O6
2-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)acetic acid chemical structure, C20H21N3O6, CAS 2368941-28-8
2-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidin-4-yl)acetic acid
CAS 2368941-28-8C20H21N3O6
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C21H25N3O5, CAS 2355289-75-5
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2355289-75-5C21H25N3O5
tert-Butyl N-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperidin-4-yl)-N-methylcarbamate chemical structure, C24H30N4O6, CAS 2154357-20-5
tert-Butyl N-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperidin-4-yl)-N-methylcarbamate
CAS 2154357-20-5C24H30N4O6
4-(3-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C18H20N4O4, CAS 2750809-60-8
4-(3-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2750809-60-8C18H20N4O4
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carboxylic acid chemical structure, C19H19N3O6, CAS 2467965-75-7
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carboxylic acid
CAS 2467965-75-7C19H19N3O6
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione chemical structure, C19H21N3O5, CAS 2740654-21-9
2-(2,6-Dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione
CAS 2740654-21-9C19H21N3O5
Thalidomide-piperidine chemical structure, C18H19N3O4, CAS 2924858-38-6
Thalidomide-piperidine
CAS 2924858-38-6C18H19N3O4
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde chemical structure, C19H19N3O5, CAS 2740654-22-0
1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde
CAS 2740654-22-0C19H19N3O5
4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride chemical structure, C18H21ClN4O4, CAS 2154342-35-3
4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
CAS 2154342-35-3C18H21ClN4O4
1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-3-piperidinecarboxylic acid chemical structure, C19H19N3O6, CAS 2864408-35-3
1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-3-piperidinecarboxylic acid
CAS 2864408-35-3C19H19N3O6
1-(2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-1,3-dioxoisoindolin-4-yl)piperidine-3-carboxylic acid chemical structure, C19H18FN3O6, CAS 2956461-11-1
1-(2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-1,3-dioxoisoindolin-4-yl)piperidine-3-carboxylic acid
CAS 2956461-11-1C19H18FN3O6
4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride chemical structure, C18H22Cl2N4O4, CAS 2955709-58-5
4-(4-Aminopiperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride
CAS 2955709-58-5C18H22Cl2N4O4
2-(2,6-Dioxopiperidin-3-yl)-4-{4-[2-(methylamino)ethyl]piperidin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride chemical structure, C21H27ClN4O4, CAS 3028140-77-1
2-(2,6-Dioxopiperidin-3-yl)-4-{4-[2-(methylamino)ethyl]piperidin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
CAS 3028140-77-1C21H27ClN4O4