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Murcko scaffold

2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione scaffold

36 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
36
With full pages
1
Scaffold SMILES

O=C1CCC(N2C(=O)c3cccc(N4CCNCC4)c3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione page
Murcko scaffold O=C1CCC(N2C(=O)c3cccc(N4CCNCC4)c3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

4-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H23N5O4, CAS 2138440-52-3
4-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2138440-52-3C19H23N5O4
2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione chemical structure, C17H18N4O4, CAS 2154342-57-9
2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione
CAS 2154342-57-9C17H18N4O4
2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride chemical structure, C17H19ClN4O4, CAS 2230956-83-7
2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
CAS 2230956-83-7C17H19ClN4O4
tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazine-1-carboxylate chemical structure, C22H26N4O6, CAS 2230956-82-6
tert-Butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperazine-1-carboxylate
CAS 2230956-82-6C22H26N4O6
4-(4-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C23H31N5O6, CAS 2357110-12-2
4-(4-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2357110-12-2C23H31N5O6
tert-Butyl N-(2-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperazin-1-yl)ethoxy)ethyl)carbamate chemical structure, C26H35N5O7, CAS 2357113-66-5
tert-Butyl N-(2-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperazin-1-yl)ethoxy)ethyl)carbamate
CAS 2357113-66-5C26H35N5O7
4-(4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C25H35N5O7, CAS 2357111-24-9
4-(4-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2357111-24-9C25H35N5O7
2-(2,6-Dioxopiperidin-3-yl)-4-(3-methylpiperazin-1-yl)isoindoline-1,3-dione chemical structure, C18H20N4O4, CAS 2748165-49-1
2-(2,6-Dioxopiperidin-3-yl)-4-(3-methylpiperazin-1-yl)isoindoline-1,3-dione
CAS 2748165-49-1C18H20N4O4
4-(4-(6-Aminohexanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C23H29N5O5, CAS 2425605-14-5
4-(4-(6-Aminohexanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2425605-14-5C23H29N5O5
4-(4-(3-Aminopropanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C20H23N5O5, CAS 2425605-12-3
4-(4-(3-Aminopropanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2425605-12-3C20H23N5O5
4-(4-(4-Aminobutanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C21H25N5O5, CAS 2412987-98-3
4-(4-(4-Aminobutanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2412987-98-3C21H25N5O5
4-(4-(5-Aminopentanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione chemical structure, C22H27N5O5, CAS 2425605-13-4
4-(4-(5-Aminopentanoyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2425605-13-4C22H27N5O5
tert-Butyl N-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperazin-1-yl)butyl)carbamate chemical structure, C26H35N5O6, CAS 2412988-05-5
tert-Butyl N-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)piperazin-1-yl)butyl)carbamate
CAS 2412988-05-5C26H35N5O6
4-[4-(3-Aminopropyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H25N5O4, CAS 2743434-19-5
4-[4-(3-Aminopropyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2743434-19-5C20H25N5O4
4-[4-(14-Amino-3,6,9,12-tetraoxatetradecan-1-yl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C27H39N5O8, CAS 2743438-54-0
4-[4-(14-Amino-3,6,9,12-tetraoxatetradecan-1-yl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2743438-54-0C27H39N5O8
4-{4-[3-(3-Aminopropoxy)propyl]piperazin-1-yl}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C23H31N5O5, CAS 2743433-90-9
4-{4-[3-(3-Aminopropoxy)propyl]piperazin-1-yl}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2743433-90-9C23H31N5O5
4-[4-(2-Azidoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H21N7O4, CAS 2825005-34-1
4-[4-(2-Azidoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2825005-34-1C19H21N7O4
4-[4-(4-Aminobutyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C21H27N5O4, CAS 2412987-55-2
4-[4-(4-Aminobutyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2412987-55-2C21H27N5O4
4-{4-[2-(2-Aminoethoxy)ethyl]piperazin-1-yl}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C21H27N5O5, CAS 2694722-69-3
4-{4-[2-(2-Aminoethoxy)ethyl]piperazin-1-yl}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2694722-69-3C21H27N5O5
4-[4-(6-Aminohexyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C23H31N5O4, CAS 2694722-62-6
4-[4-(6-Aminohexyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2694722-62-6C23H31N5O4
4-[4-(5-Aminopentyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C22H29N5O4, CAS 2694722-89-7
4-[4-(5-Aminopentyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2694722-89-7C22H29N5O4
5-Bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C17H17BrN4O4, CAS 2870644-95-2
5-Bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2870644-95-2C17H17BrN4O4
4-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Dihydrochloride chemical structure, C19H25Cl2N5O4, CAS 2761394-29-8
4-[4-(2-Aminoethyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Dihydrochloride
CAS 2761394-29-8C19H25Cl2N5O4
4-[4-(4-Aminobutyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride chemical structure, C21H29Cl2N5O4, CAS 2761410-23-3
4-[4-(4-Aminobutyl)piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride
CAS 2761410-23-3C21H29Cl2N5O4