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Murcko scaffold

Ring system with 2 rings and 16 atoms

50 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
50
With full pages
15
Scaffold SMILES

O=C(CSc1ccccn1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ccccn1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

Ethanone, 1-phenyl-2-(2-pyridinylthio)-, hydrobromide chemical structure, C13H12BrNOS, CAS 3166-30-1
Ethanone, 1-phenyl-2-(2-pyridinylthio)-, hydrobromide
CAS 3166-30-1C13H12BrNOS
1-(4-Bromophenyl)-2-[(5-nitropyridin-2-yl)sulfanyl]ethanone chemical structure, C13H9BrN2O3S, CAS 5898-27-1
1-(4-Bromophenyl)-2-[(5-nitropyridin-2-yl)sulfanyl]ethanone
CAS 5898-27-1C13H9BrN2O3S
2-[(3-Chloro-2-pyridinyl)sulfanyl]-1-phenylethanone chemical structure, C13H10ClNOS, CAS 5898-34-0
2-[(3-Chloro-2-pyridinyl)sulfanyl]-1-phenylethanone
CAS 5898-34-0C13H10ClNOS
1-Phenyl-2-pyridin-2-ylsulfanylpropan-1-one chemical structure, C14H13NOS, CAS 46811-21-6
1-Phenyl-2-pyridin-2-ylsulfanylpropan-1-one
CAS 46811-21-6C14H13NOS
6-Methyl-2-((2-oxo-2-phenylethyl)sulfanyl)-4-(trifluoromethyl)pyridine-3-carbonitrile chemical structure, C16H11F3N2OS, CAS 182127-95-3
6-Methyl-2-((2-oxo-2-phenylethyl)sulfanyl)-4-(trifluoromethyl)pyridine-3-carbonitrile
CAS 182127-95-3C16H11F3N2OS
4,6-Dimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3-carbonitrile chemical structure, C16H14N2OS, CAS 72456-88-3
4,6-Dimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3-carbonitrile
CAS 72456-88-3C16H14N2OS
2-[2-(2,4-Difluoro-phenyl)-2-oxo-ethylsulfanyl]-4-methoxymethyl-6-methyl-nicotinonitrile chemical structure, C17H14F2N2O2S, CAS 442872-56-2
2-[2-(2,4-Difluoro-phenyl)-2-oxo-ethylsulfanyl]-4-methoxymethyl-6-methyl-nicotinonitrile
CAS 442872-56-2C17H14F2N2O2S
2-[2-(4-Chloro-phenyl)-2-oxo-ethylsulfanyl]-4,6-dimethyl-nicotinamide chemical structure, C16H15ClN2O2S, CAS 402954-31-8
2-[2-(4-Chloro-phenyl)-2-oxo-ethylsulfanyl]-4,6-dimethyl-nicotinamide
CAS 402954-31-8C16H15ClN2O2S
2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile chemical structure, C17H16N2O2S, CAS 313380-12-0
2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
CAS 313380-12-0C17H16N2O2S
5-Acetyl-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyridine-3-carbonitrile chemical structure, C17H13ClN2O2S, CAS 328068-69-5
5-Acetyl-2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyridine-3-carbonitrile
CAS 328068-69-5C17H13ClN2O2S
4,5,6-Trimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3-carbonitrile chemical structure, C17H16N2OS, CAS 5231-58-3
4,5,6-Trimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyridine-3-carbonitrile
CAS 5231-58-3C17H16N2OS
4,6-Dimethyl-2-(2-oxo-2-p-tolyl-ethylsulfanyl)-nicotinamide chemical structure, C17H18N2O2S, CAS 430449-38-0
4,6-Dimethyl-2-(2-oxo-2-p-tolyl-ethylsulfanyl)-nicotinamide
CAS 430449-38-0C17H18N2O2S
2-[[2-(3-Nitrophenyl)-2-oxoethyl]thio]-3-pyridinecarboxylic acid chemical structure, C14H10N2O5S, CAS 321979-20-8
2-[[2-(3-Nitrophenyl)-2-oxoethyl]thio]-3-pyridinecarboxylic acid
CAS 321979-20-8C14H10N2O5S
2-Amino-4-ethyl-6-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}pyridine-3,5-dicarbonitrile chemical structure, C18H16N4OS, CAS 5212-40-8
2-Amino-4-ethyl-6-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}pyridine-3,5-dicarbonitrile
CAS 5212-40-8C18H16N4OS
2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-4,5,6-trimethylnicotinonitrile chemical structure, C17H15ClN2OS, CAS 313519-22-1
2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-4,5,6-trimethylnicotinonitrile
CAS 313519-22-1C17H15ClN2OS
2-((2-(2,4-Dimethylphenyl)-2-oxoethyl)thio)-4,5,6-trimethylnicotinonitrile chemical structure, C19H20N2OS, CAS 312758-04-6
2-((2-(2,4-Dimethylphenyl)-2-oxoethyl)thio)-4,5,6-trimethylnicotinonitrile
CAS 312758-04-6C19H20N2OS
2-[2-(4-Chlorophenyl)-2-oxoethylthio]pyridine-3-carboxylic acid chemical structure, C14H10ClNO3S, CAS 324779-95-5
2-[2-(4-Chlorophenyl)-2-oxoethylthio]pyridine-3-carboxylic acid
CAS 324779-95-5C14H10ClNO3S
2-[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile chemical structure, C16H13FN2OS, CAS 313976-25-9
2-[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
CAS 313976-25-9C16H13FN2OS
1-(4-Bromophenyl)-2-(pyridin-2-ylthio)ethanone chemical structure, C13H10BrNOS, CAS 5898-19-1
1-(4-Bromophenyl)-2-(pyridin-2-ylthio)ethanone
CAS 5898-19-1C13H10BrNOS
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile chemical structure, C16H13ClN2OS, CAS 313531-21-4
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-4,6-dimethylpyridine-3-carbonitrile
CAS 313531-21-4C16H13ClN2OS
4,5,6-Trimethyl-2-[2-(4-methylphenyl)-2-oxoethyl]sulfanylpyridine-3-carbonitrile chemical structure, C18H18N2OS, CAS 303017-52-9
4,5,6-Trimethyl-2-[2-(4-methylphenyl)-2-oxoethyl]sulfanylpyridine-3-carbonitrile
CAS 303017-52-9C18H18N2OS
2-[(2-Oxo-2-phenylethyl)sulfanyl]nicotinaldehyde chemical structure, C14H11NO2S, CAS 887577-13-1
2-[(2-Oxo-2-phenylethyl)sulfanyl]nicotinaldehyde
CAS 887577-13-1C14H11NO2S
2-[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile chemical structure, C17H15FN2OS, CAS 303017-47-2
2-[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile
CAS 303017-47-2C17H15FN2OS
1-(4-Fluorophenyl)-2-(2-pyridinylthio)ethanone chemical structure, C13H10FNOS, CAS 311794-61-3
1-(4-Fluorophenyl)-2-(2-pyridinylthio)ethanone
CAS 311794-61-3C13H10FNOS