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Murcko scaffold

Ring system with 4 rings and 17 atoms

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
17
Chemicals
17
With full pages
2
Scaffold SMILES

c1ncc2oc3ncc4c(c3c2n1)CCOC4

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ncc2oc3ncc4c(c3c2n1)CCOC4

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

N-(3-Methoxypropyl)-2,2-dimethyl-5-propyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine chemical structure, C21H28N4O3, CAS 896813-11-9
N-(3-Methoxypropyl)-2,2-dimethyl-5-propyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine
CAS 896813-11-9C21H28N4O3
4,4,8-Trimethyl-N-(3-propan-2-yloxypropyl)-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine chemical structure, C21H28N4O3, CAS 896826-03-2
4,4,8-Trimethyl-N-(3-propan-2-yloxypropyl)-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine
CAS 896826-03-2C21H28N4O3
8-Methoxy-2,2,5-trimethyl-1,4-dihydro-2H-3,7-dioxa-6,9,11-triaza-benzo[c]fluorene chemical structure, C16H17N3O3, CAS 896833-89-9
8-Methoxy-2,2,5-trimethyl-1,4-dihydro-2H-3,7-dioxa-6,9,11-triaza-benzo[c]fluorene
CAS 896833-89-9C16H17N3O3
N-(3-Methoxypropyl)-4,4,8-trimethyl-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine chemical structure, C19H24N4O3, CAS 896849-45-9
N-(3-Methoxypropyl)-4,4,8-trimethyl-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine
CAS 896849-45-9C19H24N4O3
8-Chloro-2,2,5-trimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine chemical structure, C15H14ClN3O2, CAS 896852-39-4
8-Chloro-2,2,5-trimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine
CAS 896852-39-4C15H14ClN3O2
4,4,8-Trimethyl-N-(3-methylbutyl)-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine chemical structure, C20H26N4O2, CAS 896854-18-5
4,4,8-Trimethyl-N-(3-methylbutyl)-5,11-dioxa-9,14,16-triazatetracyclo[8.7.0.02,7.012,17]heptadeca-1,7,9,12(17),13,15-hexaen-13-amine
CAS 896854-18-5C20H26N4O2
5-Isopropyl-N-(2-methoxyethyl)-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine chemical structure, C20H26N4O3, CAS 899393-99-8
5-Isopropyl-N-(2-methoxyethyl)-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine
CAS 899393-99-8C20H26N4O3
2-((2,2-Dimethyl-5-propyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)(methyl)amino)ethanol chemical structure, C20H26N4O3, CAS 899412-94-3
2-((2,2-Dimethyl-5-propyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)(methyl)amino)ethanol
CAS 899412-94-3C20H26N4O3
2,2'-((2,2,5-Trimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)azanediyl)diethanol chemical structure, C19H24N4O4, CAS 899406-40-7
2,2'-((2,2,5-Trimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)azanediyl)diethanol
CAS 899406-40-7C19H24N4O4
2-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)ethanol chemical structure, C20H26N4O3, CAS 900264-54-2
2-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)ethanol
CAS 900264-54-2C20H26N4O3
2-(5-Isopropyl-2,2-dimethyl-1,4-dihydro-2H-3,7-dioxa-6,9,11-triaza-benzo[c]fluoren-8-ylamino)-ethanol chemical structure, C19H24N4O3, CAS 900289-19-2
2-(5-Isopropyl-2,2-dimethyl-1,4-dihydro-2H-3,7-dioxa-6,9,11-triaza-benzo[c]fluoren-8-ylamino)-ethanol
CAS 900289-19-2C19H24N4O3
3-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-1-ol chemical structure, C21H28N4O3, CAS 896066-06-1
3-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-1-ol
CAS 896066-06-1C21H28N4O3
5-Isobutyl-N-(2-methoxyethyl)-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine chemical structure, C21H28N4O3, CAS 896077-74-0
5-Isobutyl-N-(2-methoxyethyl)-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-amine
CAS 896077-74-0C21H28N4O3
1-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-2-ol chemical structure, C21H28N4O3, CAS 896820-40-9
1-((5-Isobutyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-2-ol
CAS 896820-40-9C21H28N4O3
2-[(2,2,5-Trimethyl-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino]-1-butanol chemical structure, C19H24N4O3, CAS 896824-89-8
2-[(2,2,5-Trimethyl-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino]-1-butanol
CAS 896824-89-8C19H24N4O3
1-((5-Isopropyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-2-ol chemical structure, C20H26N4O3, CAS 899399-36-1
1-((5-Isopropyl-2,2-dimethyl-2,4-dihydro-1H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino)propan-2-ol
CAS 899399-36-1C20H26N4O3
2-[(2,2-Dimethyl-5-propyl-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino]-1-butanol chemical structure, C21H28N4O3, CAS 900279-78-9
2-[(2,2-Dimethyl-5-propyl-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl)amino]-1-butanol
CAS 900279-78-9C21H28N4O3