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Murcko scaffold

Ring system with 6 rings and 24 atoms

34 chemicals on CompoundList share this ring system.

Rings: 6
Scaffold atoms: 24
Chemicals: 34
With full pages: 9

Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)C1CCN3CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)C1CCN3CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

8-Amino-N-(3,4-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16F2N4OS, CAS 728003-23-4

8-Amino-N-(3,4-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728003-23-4C₁₉H₁₆F₂N₄OS

8-Amino-N-(2-(trifluoromethyl)phenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H17F3N4OS, CAS 902038-41-9

8-Amino-N-(2-(trifluoromethyl)phenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 902038-41-9C₂₀H₁₇F₃N₄OS

8-Amino-N-(2-ethoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C21H22N4O2S, CAS 902041-35-4

8-Amino-N-(2-ethoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 902041-35-4C₂₁H₂₂N₄O₂S

8-Amino-N-(2-chlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H17ClN4OS, CAS 902045-82-3

8-Amino-N-(2-chlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 902045-82-3C₁₉H₁₇ClN₄OS

8-Amino-N-(2-fluoro-4-methylphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H19FN4OS, CAS 902011-80-7

8-Amino-N-(2-fluoro-4-methylphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 902011-80-7C₂₀H₁₉FN₄OS

8-Amino-N-(2,4-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16F2N4OS, CAS 889969-27-1

8-Amino-N-(2,4-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889969-27-1C₁₉H₁₆F₂N₄OS

8-Amino-N-(4-chlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H17ClN4OS, CAS 728003-26-7

8-Amino-N-(4-chlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728003-26-7C₁₉H₁₇ClN₄OS

8-Amino-N-(5-chloro-2-methoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H19ClN4O2S, CAS 889969-21-5

8-Amino-N-(5-chloro-2-methoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889969-21-5C₂₀H₁₉ClN₄O₂S

8-Amino-N-(3,4-dimethoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C21H22N4O3S, CAS 728888-49-1

8-Amino-N-(3,4-dimethoxyphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728888-49-1C₂₁H₂₂N₄O₃S

8-Amino-N-(3-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H17FN4OS, CAS 728003-21-2

8-Amino-N-(3-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728003-21-2C₁₉H₁₇FN₄OS

8-Amino-N-(2,5-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16F2N4OS, CAS 728888-47-9

8-Amino-N-(2,5-difluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728888-47-9C₁₉H₁₆F₂N₄OS

N-(4-Acetylphenyl)-8-amino-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C21H20N4O2S, CAS 889969-34-0

N-(4-Acetylphenyl)-8-amino-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889969-34-0C₂₁H₂₀N₄O₂S

5-Amino-N-phenyl-7-thia-1,9-diazatetracyclo[9.2.2.0~2,10~.0~4,8~]pentadeca-2(10),3,5,8-tetraene-6-carboxamide chemical structure, C19H18N4OS, CAS 625376-26-3

5-Amino-N-phenyl-7-thia-1,9-diazatetracyclo[9.2.2.0~2,10~.0~4,8~]pentadeca-2(10),3,5,8-tetraene-6-carboxamide

CAS 625376-26-3C₁₉H₁₈N₄OS

8-Amino-N-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H17F3N4O2S, CAS 728003-22-3

8-Amino-N-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728003-22-3C₂₀H₁₇F₃N₄O₂S

Ethyl 4-{[(8-amino-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridin-7-yl)carbonyl]amino}benzoate chemical structure, C22H22N4O3S, CAS 728003-27-8

Ethyl 4-{[(8-amino-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridin-7-yl)carbonyl]amino}benzoate

CAS 728003-27-8C₂₂H₂₂N₄O₃S

8-Amino-N-(3,5-dichlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16Cl2N4OS, CAS 728888-51-5

8-Amino-N-(3,5-dichlorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 728888-51-5C₁₉H₁₆Cl₂N₄OS

8-Amino-N-(3-cyanophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H17N5OS, CAS 889947-44-8

8-Amino-N-(3-cyanophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889947-44-8C₂₀H₁₇N₅OS

8-Amino-N-(3-bromophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H17BrN4OS, CAS 889955-64-0

8-Amino-N-(3-bromophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889955-64-0C₁₉H₁₇BrN₄OS

8-Amino-N-(3-chloro-4-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16ClFN4OS, CAS 889955-68-4

8-Amino-N-(3-chloro-4-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889955-68-4C₁₉H₁₆ClFN₄OS

8-Amino-N-(4-(dimethylamino)phenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C21H23N5OS, CAS 889955-92-4

8-Amino-N-(4-(dimethylamino)phenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 889955-92-4C₂₁H₂₃N₅OS

8-Amino-N-(2,5-dichlorophenyl)-1,2,3,4-tetrahydro-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H16Cl2N4OS, CAS 923552-23-2

8-Amino-N-(2,5-dichlorophenyl)-1,2,3,4-tetrahydro-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 923552-23-2C₁₉H₁₆Cl₂N₄OS

8-Amino-N-(2-fluorophenyl)-1,2,3,4-tetrahydro-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C19H17FN4OS, CAS 923552-25-4

8-Amino-N-(2-fluorophenyl)-1,2,3,4-tetrahydro-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 923552-25-4C₁₉H₁₇FN₄OS

8-Amino-N-(4-methoxy-2-methylphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C21H22N4O2S, CAS 923552-53-8

8-Amino-N-(4-methoxy-2-methylphenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 923552-53-8C₂₁H₂₂N₄O₂S

8-Amino-N-(4-cyanophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide chemical structure, C20H17N5OS, CAS 923552-55-0

8-Amino-N-(4-cyanophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide

CAS 923552-55-0C₂₀H₁₇N₅OS