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Murcko scaffold

1-(Phenoxymethyl)-1,2,3,4-tetrahydroisoquinoline scaffold

47 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
47
With full pages
12
Scaffold SMILES

c1ccc(OCC2NCCc3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenoxymethyl)-1,2,3,4-tetrahydroisoquinoline page
Murcko scaffold c1ccc(OCC2NCCc3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

Clofeverine chemical structure, C16H16ClNO3, CAS 54340-63-5
Clofeverine
CAS 54340-63-5C16H16ClNO3
1-[(4-Fluorophenoxy)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H20FNO3, CAS 865546-37-8
1-[(4-Fluorophenoxy)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS 865546-37-8C18H20FNO3
1-((4-Ethylphenoxy)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline chemical structure, C20H25NO3, CAS 865546-38-9
1-((4-Ethylphenoxy)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CAS 865546-38-9C20H25NO3
1-((4-Isopropylphenoxy)methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline chemical structure, C21H27NO3, CAS 865546-39-0
1-((4-Isopropylphenoxy)methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS 865546-39-0C21H27NO3
6,7-Dimethoxy-1-[(4-nitrophenoxy)methyl]-1,2,3,4-tetrahydroisoquinoline chemical structure, C18H20N2O5, CAS 887201-39-0
6,7-Dimethoxy-1-[(4-nitrophenoxy)methyl]-1,2,3,4-tetrahydroisoquinoline
CAS 887201-39-0C18H20N2O5
6,7-Dimethoxy-1-{[3-(trifluoromethyl)phenoxy]methyl}-1,2,3,4-tetrahydroisoquinoline chemical structure, C19H20F3NO3, CAS 865546-41-4
6,7-Dimethoxy-1-{[3-(trifluoromethyl)phenoxy]methyl}-1,2,3,4-tetrahydroisoquinoline
CAS 865546-41-4C19H20F3NO3
Methyl 4-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methoxy]benzoate chemical structure, C20H23NO5, CAS 887201-43-6
Methyl 4-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methoxy]benzoate
CAS 887201-43-6C20H23NO5
3-Chloro-1-(6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one chemical structure, C22H23ClF3NO4, CAS 486452-12-4
3-Chloro-1-(6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-one
CAS 486452-12-4C22H23ClF3NO4
1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-N-methyl-3,4-dihydroisoquinoline-2(1H)-carbothioamide chemical structure, C22H28N2O3S, CAS 536698-42-7
1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-N-methyl-3,4-dihydroisoquinoline-2(1H)-carbothioamide
CAS 536698-42-7C22H28N2O3S
N-Butyl-6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide chemical structure, C24H29F3N2O3S, CAS 536700-21-7
N-Butyl-6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide
CAS 536700-21-7C24H29F3N2O3S
1-(6,7-Dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)butan-1-one chemical structure, C23H26F3NO4, CAS 486452-05-5
1-(6,7-Dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)butan-1-one
CAS 486452-05-5C23H26F3NO4
Methyl 4-{[2-(4-chlorobutanoyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methoxy}benzoate chemical structure, C24H28ClNO6, CAS 486452-53-3
Methyl 4-{[2-(4-chlorobutanoyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methoxy}benzoate
CAS 486452-53-3C24H28ClNO6
1-[(3,5-Dimethylphenoxy)methyl]-6,7-dimethoxy-N-(2-methoxyethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioamide chemical structure, C24H32N2O4S, CAS 536701-34-5
1-[(3,5-Dimethylphenoxy)methyl]-6,7-dimethoxy-N-(2-methoxyethyl)-3,4-dihydro-1H-isoquinoline-2-carbothioamide
CAS 536701-34-5C24H32N2O4S
4-Chloro-1-(6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)butan-1-one chemical structure, C23H25ClF3NO4, CAS 486452-14-6
4-Chloro-1-(6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)butan-1-one
CAS 486452-14-6C23H25ClF3NO4
1-(1-((4-Isopropylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone chemical structure, C23H29NO4, CAS 449765-21-3
1-(1-((4-Isopropylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS 449765-21-3C23H29NO4
1-(1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pentan-1-one chemical structure, C25H33NO4, CAS 449764-84-5
1-(1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pentan-1-one
CAS 449764-84-5C25H33NO4
N-Ethyl-6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide chemical structure, C22H25F3N2O3S, CAS 536700-20-6
N-Ethyl-6,7-dimethoxy-1-((3-(trifluoromethyl)phenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide
CAS 536700-20-6C22H25F3N2O3S
1-(1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone chemical structure, C22H27NO4, CAS 449764-87-8
1-(1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS 449764-87-8C22H27NO4
1-(1-((3,5-Dimethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylbutan-1-one chemical structure, C25H33NO4, CAS 680605-29-2
1-(1-((3,5-Dimethylphenoxy)methyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylbutan-1-one
CAS 680605-29-2C25H33NO4
1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-N-(2-methoxyethyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide chemical structure, C24H32N2O4S, CAS 536698-46-1
1-((4-Ethylphenoxy)methyl)-6,7-dimethoxy-N-(2-methoxyethyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide
CAS 536698-46-1C24H32N2O4S
Ethyl 4-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methoxy]benzoate chemical structure, C21H25NO5, CAS 865546-42-5
Ethyl 4-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methoxy]benzoate
CAS 865546-42-5C21H25NO5
1-[6,7-Dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methylbutan-1-one chemical structure, C24H31NO5, CAS 680603-64-9
1-[6,7-Dimethoxy-1-[(4-methoxyphenoxy)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-3-methylbutan-1-one
CAS 680603-64-9C24H31NO5
N-(tert-Butyl)-6,7-dimethoxy-1-((4-nitrophenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide chemical structure, C23H29N3O5S, CAS 536699-85-1
N-(tert-Butyl)-6,7-dimethoxy-1-((4-nitrophenoxy)methyl)-3,4-dihydroisoquinoline-2(1H)-carbothioamide
CAS 536699-85-1C23H29N3O5S
1-[1-[(3,5-Dimethylphenoxy)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-methylpropan-1-one chemical structure, C24H31NO4, CAS 486451-67-6
1-[1-[(3,5-Dimethylphenoxy)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-methylpropan-1-one
CAS 486451-67-6C24H31NO4