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Murcko scaffold

Ring system with 4 rings and 23 atoms

6 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
6
With full pages
3
Scaffold SMILES

O=C(c1conc1-c1ccccc1)N1CCCc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1conc1-c1ccccc1)N1CCCc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

1-{[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline chemical structure, C21H18ClFN2O2, CAS 353775-26-5
1-{[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl}-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline
CAS 353775-26-5C21H18ClFN2O2
5-Methyl-3-phenylisoxazol-4-yl 1,2,3,4-tetrahydroquinolyl ketone chemical structure, C20H18N2O2, CAS 352693-23-3
5-Methyl-3-phenylisoxazol-4-yl 1,2,3,4-tetrahydroquinolyl ketone
CAS 352693-23-3C20H18N2O2
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-(3,4-dihydro-2H-quinolin-1-yl)methanone chemical structure, C20H17ClN2O2, CAS 328105-20-0
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-(3,4-dihydro-2H-quinolin-1-yl)methanone
CAS 328105-20-0C20H17ClN2O2
3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl 1,2,3,4-tetrahydroquinolyl ketone chemical structure, C20H16Cl2N2O2, CAS 216501-66-5
3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl 1,2,3,4-tetrahydroquinolyl ketone
CAS 216501-66-5C20H16Cl2N2O2
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)methanone chemical structure, C21H19ClN2O2, CAS 1024388-13-3
[3-(2-Chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-(6-methyl-3,4-dihydro-2H-quinolin-1-yl)methanone
CAS 1024388-13-3C21H19ClN2O2
3-(6-Chloro-2-fluorophenyl)-5-methylisoxazol-4-yl 6-methyl(1,2,3,4-tetrahydroquinolyl) ketone chemical structure, C21H18ClFN2O2, CAS 1024580-16-2
3-(6-Chloro-2-fluorophenyl)-5-methylisoxazol-4-yl 6-methyl(1,2,3,4-tetrahydroquinolyl) ketone
CAS 1024580-16-2C21H18ClFN2O2