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Murcko scaffold

Ring system with 4 rings and 23 atoms

6 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
6
With full pages
3
Scaffold SMILES

c1ccc(-c2ncn(C3CCNCC3)c2-c2ccncn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ncn(C3CCNCC3)c2-c2ccncn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

SB-220025 chemical structure, C18H19FN6, CAS 165806-53-1
SB-220025
CAS 165806-53-1C18H19FN6
SB-242235 chemical structure, C19H20FN5O, CAS 193746-75-7
SB-242235
CAS 193746-75-7C19H20FN5O
4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazol-4-yl]-2-isopropoxy-pyrimidine chemical structure, C21H24FN5O, CAS 193746-76-8
4-[5-(4-Fluoro-phenyl)-3-piperidin-4-yl-3H-imidazol-4-yl]-2-isopropoxy-pyrimidine
CAS 193746-76-8C21H24FN5O
5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride chemical structure, C18H22Cl3FN6, CAS 197446-75-6
5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride
CAS 197446-75-6C18H22Cl3FN6
Ethyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-amine chemical structure, C21H25FN6, CAS 180869-17-4
Ethyl-{4-[5-(4-fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-amine
CAS 180869-17-4C21H25FN6
4-[5-(4-Fluoro-phenyl)-3-(1-isopropyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine chemical structure, C21H25FN6, CAS 389122-22-9
4-[5-(4-Fluoro-phenyl)-3-(1-isopropyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine
CAS 389122-22-9C21H25FN6