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Murcko scaffold

1H-Imidazo[4,5-b]pyrazine scaffold

70 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
70
With full pages
8
Scaffold SMILES

c1cnc2[nH]cnc2n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H-Imidazo[4,5-b]pyrazine page
Murcko scaffold c1cnc2[nH]cnc2n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

1,5,6-Trimethyl-1H-imidazo[4,5-b]pyrazine chemical structure, C8H10N4, CAS 40089-71-2
1,5,6-Trimethyl-1H-imidazo[4,5-b]pyrazine
CAS 40089-71-2C8H10N4
2-(Trifluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6H3F3N4, CAS 58885-00-0
2-(Trifluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 58885-00-0C6H3F3N4
2-Methyl-1H-imidazo[4,5-b]pyrazine chemical structure, C6H6N4, CAS 38956-46-6
2-Methyl-1H-imidazo[4,5-b]pyrazine
CAS 38956-46-6C6H6N4
2-(Trichloromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6H3Cl3N4, CAS 58885-18-0
2-(Trichloromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 58885-18-0C6H3Cl3N4
1,2,5,6-Tetrachloro-1H-imidazo[4,5-b]pyrazine chemical structure, C5Cl4N4, CAS 79100-23-5
1,2,5,6-Tetrachloro-1H-imidazo[4,5-b]pyrazine
CAS 79100-23-5C5Cl4N4
1-(1H-Imidazo[4,5-b]pyrazin-2-ylsulfanyl)propan-2-one chemical structure, C8H8N4OS, CAS 79100-25-7
1-(1H-Imidazo[4,5-b]pyrazin-2-ylsulfanyl)propan-2-one
CAS 79100-25-7C8H8N4OS
1H-Imidazo(4,5-b)pyrazine, 2-(isopropylamino)-1,5,6-trimethyl- chemical structure, C11H17N5, CAS 55635-68-2
1H-Imidazo(4,5-b)pyrazine, 2-(isopropylamino)-1,5,6-trimethyl-
CAS 55635-68-2C11H17N5
1H-Imidazo(4,5-b)pyrazine, 2-(diethylamino)-1,5,6-trimethyl- chemical structure, C12H19N5, CAS 55635-67-1
1H-Imidazo(4,5-b)pyrazine, 2-(diethylamino)-1,5,6-trimethyl-
CAS 55635-67-1C12H19N5
2-Diethylaminoethylamino-1,5,6-trimethyl-1H-imidazo(4,5-b)pyrazine chemical structure, C14H24N6, CAS 55635-72-8
2-Diethylaminoethylamino-1,5,6-trimethyl-1H-imidazo(4,5-b)pyrazine
CAS 55635-72-8C14H24N6
Ethanol, 2,2'-((1,5,6-trimethyl-1H-imidazo(4,5-b)pyrazin-2-yl)imino)bis- chemical structure, C12H19N5O2, CAS 55635-73-9
Ethanol, 2,2'-((1,5,6-trimethyl-1H-imidazo(4,5-b)pyrazin-2-yl)imino)bis-
CAS 55635-73-9C12H19N5O2
Ethyl 2-[(5,6-dichloro-1H-imidazo[4,5-b]pyrazin-2-yl)sulfanyl]acetate chemical structure, C9H8Cl2N4O2S, CAS 79100-27-9
Ethyl 2-[(5,6-dichloro-1H-imidazo[4,5-b]pyrazin-2-yl)sulfanyl]acetate
CAS 79100-27-9C9H8Cl2N4O2S
RefChem:357267 chemical structure, C6HCl2F3N4, CAS 53338-40-2
RefChem:357267
CAS 53338-40-2C6HCl2F3N4
5,6-Dichloro-2-(trichloromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6HCl5N4, CAS 58885-17-9
5,6-Dichloro-2-(trichloromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 58885-17-9C6HCl5N4
5,6-Dichloro-2-[chloro(difluoro)methyl]-1H-imidazo[4,5-b]pyrazine chemical structure, C6HCl3F2N4, CAS 58885-09-9
5,6-Dichloro-2-[chloro(difluoro)methyl]-1H-imidazo[4,5-b]pyrazine
CAS 58885-09-9C6HCl3F2N4
5,6-Dichloro-2-(1,1,2,2,2-pentafluoroethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C7HCl2F5N4, CAS 53338-41-3
5,6-Dichloro-2-(1,1,2,2,2-pentafluoroethyl)-1H-imidazo[4,5-b]pyrazine
CAS 53338-41-3C7HCl2F5N4
(5,6-Dichloro-1H-imidazo[4,5-b]pyrazin-2-yl)methanol chemical structure, C6H4Cl2N4O, CAS 58885-15-7
(5,6-Dichloro-1H-imidazo[4,5-b]pyrazin-2-yl)methanol
CAS 58885-15-7C6H4Cl2N4O
5,6-Dichloro-2-(chloromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6H3Cl3N4, CAS 58885-02-2
5,6-Dichloro-2-(chloromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 58885-02-2C6H3Cl3N4
5,6-Dibromo-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6HBr2F3N4, CAS 53338-44-6
5,6-Dibromo-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 53338-44-6C6HBr2F3N4
5,6-Dichloro-2-(difluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6H2Cl2F2N4, CAS 53338-43-5
5,6-Dichloro-2-(difluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 53338-43-5C6H2Cl2F2N4
5,6-Dichloro-2-(1,1,2,2,3,3,3-heptafluoropropyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C8HCl2F7N4, CAS 53338-42-4
5,6-Dichloro-2-(1,1,2,2,3,3,3-heptafluoropropyl)-1H-imidazo[4,5-b]pyrazine
CAS 53338-42-4C8HCl2F7N4
5,6-Difluoro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6HF5N4, CAS 53338-45-7
5,6-Difluoro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 53338-45-7C6HF5N4
5,6-Dimethyl-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C8H7F3N4, CAS 500901-30-4
5,6-Dimethyl-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 500901-30-4C8H7F3N4
5,6-Dichloro-2-heptadecyl-1H-imidazo[4,5-b]pyrazine chemical structure, C22H36Cl2N4, CAS 58885-13-5
5,6-Dichloro-2-heptadecyl-1H-imidazo[4,5-b]pyrazine
CAS 58885-13-5C22H36Cl2N4
5,6-Dichloro-2-(fluoromethyl)-1H-imidazo[4,5-b]pyrazine chemical structure, C6H3Cl2FN4, CAS 58885-16-8
5,6-Dichloro-2-(fluoromethyl)-1H-imidazo[4,5-b]pyrazine
CAS 58885-16-8C6H3Cl2FN4