Murcko scaffold
Ring system with 4 rings and 24 atoms
28 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 28
- With full pages
- 5
Scaffold SMILES
O=S(=O)(c1csc2ccccc12)N1CCN(c2ccccc2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 28 of 28 chemicals
![Methyl 3-((4-(4-acetylphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate chemical structure, C22H22N2O5S2, CAS 932354-03-5](/s/XFPJUNXTKPPRQV-UHFFFAOYSA-N.svg)
Methyl 3-((4-(4-acetylphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate
CAS 932354-03-5C22H22N2O5S2
![Ethyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C22H24N2O5S2, CAS 932520-32-6](/s/BRMJQTDALUVFFD-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932520-32-6C22H24N2O5S2
![Ethyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C23H26N2O4S2, CAS 895266-80-5](/s/RKTLUBPSBWAAKJ-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 895266-80-5C23H26N2O4S2
![Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H21FN2O4S2, CAS 932464-72-7](/s/PJXMWEBGIDUEQY-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932464-72-7C21H21FN2O4S2
![Ethyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C23H26N2O4S2, CAS 895266-87-2](/s/UUJVXTQIBAALMH-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 895266-87-2C23H26N2O4S2
![Ethyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C23H26N2O4S2, CAS 932354-31-9](/s/OGSCKFWLPNOINK-UHFFFAOYSA-N.svg)
Ethyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932354-31-9C23H26N2O4S2
![Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate chemical structure, C22H23FN2O4S2, CAS 941893-05-6](/s/JXXMUHACVHXXAJ-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate
CAS 941893-05-6C22H23FN2O4S2
![Ethyl 3-[(4-phenylpiperazin-1-yl)sulfonyl]-1-benzothiophene-2-carboxylate chemical structure, C21H22N2O4S2, CAS 895266-73-6](/s/UNXZITKKVLWOLU-UHFFFAOYSA-N.svg)
Ethyl 3-[(4-phenylpiperazin-1-yl)sulfonyl]-1-benzothiophene-2-carboxylate
CAS 895266-73-6C21H22N2O4S2
![Methyl 3-((4-(4-methoxyphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate chemical structure, C21H22N2O5S2, CAS 899725-36-1](/s/LXPRYEWPDASNMC-UHFFFAOYSA-N.svg)
Methyl 3-((4-(4-methoxyphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate
CAS 899725-36-1C21H22N2O5S2
![Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H22N2O5S2, CAS 932303-35-0](/s/SPPVHYOLNOEJSP-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932303-35-0C21H22N2O5S2
![Ethyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C23H26N2O4S2, CAS 941962-23-8](/s/AYVFNYOGUWCUFQ-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 941962-23-8C23H26N2O4S2
![Ethyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C22H24N2O5S2, CAS 932354-29-5](/s/FSHVYYYCTQVHBF-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932354-29-5C22H24N2O5S2
![Ethyl 3-((4-(4-acetylphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate chemical structure, C23H24N2O5S2, CAS 932303-70-3](/s/FAKJIULFFIHBFW-UHFFFAOYSA-N.svg)
Ethyl 3-((4-(4-acetylphenyl)piperazin-1-yl)sulfonyl)benzo[b]thiophene-2-carboxylate
CAS 932303-70-3C23H24N2O5S2
![Methyl 4-fluoro-3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H21FN2O5S2, CAS 941962-35-2](/s/PIJONNANFKMCGI-UHFFFAOYSA-N.svg)
Methyl 4-fluoro-3-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 941962-35-2C21H21FN2O5S2
![Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C20H19ClN2O4S2, CAS 899725-34-9](/s/ZUPLIAYEBKNAST-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 899725-34-9C20H19ClN2O4S2
![Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H21ClN2O4S2, CAS 899725-40-7](/s/BSIBVBPNVVANQP-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 899725-40-7C21H21ClN2O4S2
![Ethyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H21FN2O4S2, CAS 932303-64-5](/s/GRYJHWNORCGDKT-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932303-64-5C21H21FN2O4S2
![Ethyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C21H21ClN2O4S2, CAS 932520-29-1](/s/GLVXPLWCGUMXPI-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932520-29-1C21H21ClN2O4S2
![Ethyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C22H23ClN2O4S2, CAS 932520-35-9](/s/GAZOGLKPGFBPKW-UHFFFAOYSA-N.svg)
Ethyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 932520-35-9C22H23ClN2O4S2
![Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate chemical structure, C22H21FN2O5S2, CAS 941893-11-4](/s/YNYLBBOBRDPWDR-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate
CAS 941893-11-4C22H21FN2O5S2
![Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate chemical structure, C22H23FN2O4S2, CAS 941962-37-4](/s/CCBRXSHUWBRQFV-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate
CAS 941962-37-4C22H23FN2O4S2
![Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C22H24N2O4S2, CAS 899977-59-4](/s/FXMONIVXKKAXLM-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 899977-59-4C22H24N2O4S2
![Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C20H19FN2O4S2, CAS 899725-38-3](/s/SGMUMQWFENQTTO-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 899725-38-3C20H19FN2O4S2
![Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate chemical structure, C22H24N2O4S2, CAS 899966-15-5](/s/YXXRGJNWGVDHKF-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate
CAS 899966-15-5C22H24N2O4S2
- Methyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate899977-61-8C22H24N2O4S2
- Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate899978-11-1C22H24N2O4S2
- Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}-4-fluoro-1-benzothiophene-2-carboxylate900000-20-6C22H23FN2O4S2
- Methyl 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-1-benzothiophene-2-carboxylate932519-94-3C20H19ClN2O4S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc1](/scaffold/HZESCNHZDRDJQT-UHFFFAOYSA-N/structure.svg)
c1ccc(N2CCN(Cc3c[nH]c4ncccc34)CC2)cc14 chemicals![Scaffold O=c1[nH]c(=O)c2c(ncn2CN2CCN(c3ccccc3)CC2)[nH]1](/scaffold/CUAWFKFPKZBWJU-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2c(ncn2CN2CCN(c3ccccc3)CC2)[nH]12 chemicals![Scaffold O=C(c1n[nH]c2ccccc12)N1CCN(c2ccccc2)CC1](/scaffold/FBDNDPPQEFBFJC-UHFFFAOYSA-N/structure.svg)
O=C(c1n[nH]c2ccccc12)N1CCN(c2ccccc2)CC12 chemicals![Scaffold c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1](/scaffold/FDOZNCJWYJMHAG-UHFFFAOYSA-N/structure.svg)
c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc12 chemicals
O=C1C(=O)N(CN2CCN(c3ccccc3)CC2)c2ccccc212 chemicals![Scaffold c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc1](/scaffold/XNXQFTTXHFQTRX-UHFFFAOYSA-N/structure.svg)
c1ccc(C2CCN(Cc3c[nH]c4ccccc34)CC2)cc12 chemicals
c1ccc(-c2ccc(Cn3cnc4ccccc43)cc2)cc12 chemicals![Scaffold c1ccc2c(CN3CCC(N4CCCCC4)CC3)c[nH]c2c1](/scaffold/AJZHZUSLJZOJHC-UHFFFAOYSA-N/structure.svg)
c1ccc2c(CN3CCC(N4CCCCC4)CC3)c[nH]c2c11 chemical
c1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc11 chemical
O=C1C(=O)N(Cc2ccc(-c3ccccc3)cc2)c2ccccc211 chemical![Scaffold O=C(c1nnn2cc[nH]c(=O)c12)N1CCN(c2ccccc2)CC1](/scaffold/BXNQHEHRXWIZHR-UHFFFAOYSA-N/structure.svg)
O=C(c1nnn2cc[nH]c(=O)c12)N1CCN(c2ccccc2)CC11 chemical
O=C1Nc2ccccc2C1=Cc1ccc(N2CCOCC2)cc11 chemical